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oai:ojs.www.eurjchem.com:article/55 2011-12-31T08:09:40Z eurjchem:ART driver

Synthesis and biological activity of functionalized phosphorus derivatives of isatin imines El-Sawi, Emtithal Ahmed Mostafa, Tahia Bayoumy Radwan, Hyam Ali Mass spectroscopy Phosphorylation Triphenylphosphine Schiff bases X-ray crystallography Antimicrobial activity Isatin-3-imine derivatives (1a-d) have been synthesized. These compounds were then converted into phosphorylated products 2a, 2c with triethylphosphite and 3a-d with triphenylphosphine. The structures of the new compounds were confirmed by elemental analyses, IR, UV/VIS, 1H NMR, 13C NMR and MS studies. The structure of compound 1a was also confirmed by single crystal X-ray diffraction studies. Compounds 1b-d and 3c-d exhibited potent antibacterial activity against Bacillus subtilis and Escherichia Coli. Compound 3a was found to exhibit antifungal activity against the tested organisms. Atlanta Publishing House LLC 2011-12-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf chemical/x-cif https://www.eurjchem.com/index.php/eurjchem/article/view/55 10.5155/eurjchem.2.4.539-543.55 European Journal of Chemistry; Vol. 2 No. 4 (2011): December 2011; 539-543 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/55/PDF https://www.eurjchem.com/index.php/eurjchem/article/view/55/2538