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oai:ojs.www.eurjchem.com:article/551 2012-08-06T14:50:19Z eurjchem:ART driver

Microwave-assisted solvent free efficient synthesis of 1,3,4-oxadiazole-2(3H)-thiones and their potent in vitro urease inhibition activity Shahzad, Sohail Anjum Yar, Muhammad Khan, Zulfiqar Ali Khan, Islam Ullah Naqvi, Syed Ali Raza Mahmood, Nasir Khan, Khalid Mohammed High yield Hydrazides Solvent free Urease inhibition Microwave-irradiation Substituted-1 3 4-oxadiazole An efficient solvent free microwave assisted synthesis of 5-substituted-1,3,4-oxadiazole-2(3H)-thiones (2a-2r) from hydrazides and carbon disulfide has been accomplished in good to excellent yield. The urease inhibition activity of the resulting compounds was investigated. Preliminary bioassay indicated that the compound 2j bearing 2-bromo substituent is the most active inhibitor exhibiting IC50 12.60 ± 0.92 μM. Atlanta Publishing House LLC 2012-06-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/551 10.5155/eurjchem.3.2.143-146.551 European Journal of Chemistry; Vol. 3 No. 2 (2012): June 2012; 143-146 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/551/PDF