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oai:ojs.www.eurjchem.com:article/588 2012-08-06T14:50:19Z eurjchem:ART driver

Novel indole-2-carboxylic acid analogues: Synthesis and a new light in to their antioxidant potentials Naik, Nagaraja Sharath, Vishwanath Kumar, Honnaiah Vijay DPPH Antioxidant activity Substituted anilines Indole-2-carboxylic acid Indole-2-carboxamide Butylated hydroxy anisole Two series of novel indole-2-carboxylic acid derivatives is reported. In the first series, N-substituted derivatives (3a-h) were synthesized via acylation of indole-2-carboxylic acid followed by aldol condensation reaction. Whereas, in the second series, indole-2-carboxamides (5a-g) were synthesized through conversion of acid to its acid chloride followed by coupling of substituted anilines. Structures of the newly synthesized compounds were confirmed by elemental analysis and spectral IR, 1H NMR and mass data and were screened for antioxidant activity. Among the first series, compound 3g showed higher antioxidant activity and whereas, in the second series compounds 5b and 5c exhibited potential antioxidant activity. Compounds 3g, 5b and 5c exhibited for its enhanced antioxidant activity. Atlanta Publishing House LLC 2012-06-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/588 10.5155/eurjchem.3.2.214-219.588 European Journal of Chemistry; Vol. 3 No. 2 (2012): June 2012; 214-219 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/588/PDF