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oai:ojs.www.eurjchem.com:article/592 2012-08-06T14:50:19Z eurjchem:ART driver

Synthesis, structure characterization and biological evaluation of new 6,8-dichloro-2-methyl-4H-chromen-4-one derivatives Salem, Marwa Sayed Marzouk, Magda Ismail Ali, Salma Nasser Madkour, Hassan Mohamed Fawzy Thiation 2-Styrylchromones 2-Methylchromone Diels-Alder reaction Biological evaluation Heterocyclic transformations The typical active methyl functionality of 6,8-dichloro-2-methyl-4H-chromen-4-one is utilized to obtain 2-styrylchromones, pyruvate ester and phthalide via reactions with aromatic carboxaldehydes, diethyl oxalate and phthalic anhydride respectively. The phthalide provides illustrative example to convert a heterocyclic compound to an aliphatic one via the effect of alcoholic sodium methoxide. Bromination and cycloaddition reactions of 2-styrylchromones afford vicinal dibromide and adducts respectively. This work presents to the art a typical example of heterocyclic systems transformations through the conversion of the starting chromone to coumarin under the influence of thionyl chloride followed by aqueous potassium hydroxide. Some heterocyclic systems like pyrazole, isoxazol and quinolinone are obtained from the target chromone by treatment with hydrazines, hydroxylamine hydrochloride and ammonium acetate respectively. Thiation of starting chromone interestingly affords a dithiated product instead of the expected monothiated one. Antibacterial and antifungal activities of some synthesized compounds have been screened. Atlanta Publishing House LLC 2012-06-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/592 10.5155/eurjchem.3.2.220-227.592 European Journal of Chemistry; Vol. 3 No. 2 (2012): June 2012; 220-227 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/592/PDF