2026-05-25T00:40:09Z https://www.eurjchem.com/index.php/eurjchem/oai

oai:ojs.www.eurjchem.com:article/596 2012-08-06T14:50:19Z eurjchem:ART driver

In-vitro cytotoxic and radiosensitizing evaluation of novel 2-pyridone, isoquinoline, chromene and chromenopyridone derivatives Al-Said, Mansour Sulaiman El-Gazzar, Marwa Galal Ghorab, Mostafa Mohammed Cytotoxic Chromene 2-Pyridone Isoquinoline Radiosensitizing Chromenopyridone On the account of the reported anticancer activity of 2-pyridone, a new series of ethyl-1,6-dihydropyridine-3-carboxylate (4a-j), 1-oxo-1,2-dihydroisoquinoline-7-carbonitrile (6a-h), 2H-chromene (7,8) and 3H-chromeno[3,4-c]pyridone derivatives (9,10) were synthesized and tested for in-vitro anticancer activity against Ehrlich Ascites Carcinoma (EAC) cell line and human liver cell line (HEPG2). The structures of the synthesized compounds were confirmed by analytical and spectral data. Furthermore, radiosensitization study was performed for the most potent compounds (4a, 4d, 6a, 6c, 6e and 10). Atlanta Publishing House LLC 2012-06-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/596 10.5155/eurjchem.3.2.228-234.596 European Journal of Chemistry; Vol. 3 No. 2 (2012): June 2012; 228-234 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/596/PDF