2026-04-21T08:58:12Z https://www.eurjchem.com/index.php/eurjchem/oai

oai:ojs.www.eurjchem.com:article/613 2012-12-31T23:10:35Z eurjchem:ART driver

Synthesis, characterization and molecular docking studies of novel S-substituted phenacyl-1,3,4-thiadiazole-thiol derivatives as antimicrobial agents Kerur, Shashidhar Alagawadi, Kallanagouda Zhu, Hailiang Manvi, Fakkirappa 1 3 4-Thiadiazole Phenacyl bromide Molecular docking Antimicrobial activity Antitubercular activity Mycobacterium tuberculosis In the present study, synthesis and antimicrobial activity of 2,5-disubstituted 1,3,4-thiadiazole derivatives 5a-f are described. The structures of the newly synthesized compounds were confirmed by FT-IR, 1H NMR, 13C NMR, mass and elemental analysis. All compounds were screened for antitubercular and antimicrobial activity. Molecular modeling studies were performed to dock compounds into the ecKAS III binding site, which suggested probable inhibition mechanism. The results revealed that most of the compounds showed high to moderate biological activity against tested microorganisms. Atlanta Publishing House LLC 2012-09-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/613 10.5155/eurjchem.3.3.293-297.613 European Journal of Chemistry; Vol. 3 No. 3 (2012): September 2012; 293-297 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/613/PDF