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oai:ojs.www.eurjchem.com:article/655 2012-12-30T22:55:20Z eurjchem:ART driver

Regiospecific synthesis of some novel N-nucleosides of 4-amino-5-substituted-1,2,4-triazole-3-thiones and their in-vitro antimicrobial activity Nadeem, Humaira Ashraf, Zaman Spectroscopy N-nucleosides Regiospecificity Antimicrobial activity 1 2 4-Triazole-3-thiones 5-Aryl/hetero aryl substitution 4-Amino-5-substituted-1,2,4-triazole-3-thiones were prepared by following two different reaction routes and comparing the effectiveness of using different reaction conditions. The coupling of aminotriazoles with acetylated α-bromo-D-glucose furnished protected N-nucleosides regiospecifically. The reagents used gave only one regioisomer N-glycosides not the other S-nucleosides. The protected nucleosides upon deacetylation using methanolic ammonia afforded deprotected products. The chemical structures of synthesized compounds were confirmed by FT-IR, 1H NMR, 13C NMR, mass spectroscopic and elemental analysis data. All of the synthesized compounds were tested against ten different gram positive and gram negative bacterial strains which exhibited moderate to good antibacterial activity. The deprotected nucleosides portrayed high antibacterial activity than 4-amino-5-substituted-1,2,4-triazole-3-thiones and protected nucleosides against selected bacteria. Atlanta Publishing House LLC 2012-12-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/655 10.5155/eurjchem.3.4.485-492.655 European Journal of Chemistry; Vol. 3 No. 4 (2012): December 2012; 485-492 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/655/PDF