2026-05-07T09:31:03Z https://www.eurjchem.com/index.php/eurjchem/oai

oai:ojs.www.eurjchem.com:article/723 2013-06-30T03:41:05Z eurjchem:ART driver

Regioselective synthesis of some functionalized 3,4’-bis-(pyrazolyl)ketones and chemoselectivity in their reaction with hydrazine hydrate Hassaneen, Hamdi Mahmoud Shawali, Ahmad Sami Enaminones Enamino esters Regioselectivity Chemoselectivity Hydrazonoyl halides Pyrazolo[3 4-d]pyridazines A new enamino ester, (E)-ethyl 3-(dipropylamino)acrylate, was prepared and used for synthesis of various pyrazole derivatives, 4a-k and 5a-d. Other new enaminone, (E)-ethyl 3-(3-(dimethylamino)acryloyl)-1-(4-nitrophenyl)-1H-pyrazole-4-carboxylate (8), was also prepared from compound 4a and utilized as precursor for synthesis of different functionalized 3,4'-bis-pyrazolyl ketones 9a-c, 10a-c. The site selectivity in hydrazinolysis of the latter was studied. The structures of the products namely pyrazolo[3,4-d]pyridazine derivatives 11(13) were confirmed by spectral and elemental analyses and by alternate unambiguous synthesis. Atlanta Publishing House LLC 2013-06-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/723 10.5155/eurjchem.4.2.102-109.723 European Journal of Chemistry; Vol. 4 No. 2 (2013): June 2013; 102-109 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/723/PDF