2026-05-07T09:45:04Z https://www.eurjchem.com/index.php/eurjchem/oai

oai:ojs.www.eurjchem.com:article/749 2013-06-30T03:41:05Z eurjchem:ART driver

An efficient synthesis of some new isolated and fused 2-oxo-2H-chromene derivatives as antimicrobial and antitumor agents El-Shaaer, Hafez Mohamed Synthesis Antitumor activity Cyclocondensation 2-Oxo-2H-chromene Antimicrobial Activity Chromeno[3 4-c]pyridin-5-ones An efficient synthesis of the biologically active novel systems derived from the reaction of 4-methyl-2-oxo-2H-chromene-3-carbonitrile (1) with sodium hydroxide and/or DMF-DMA and cyclocondensation reactions of 4-[(E)-2-(dimethylamino)ethenyl]-2-oxo-2H-chromene-3-carbonitrile (5) with nitrogen nucleophilic reagents afforded the corresponding 4-iminochromeno[3,4-c]pyridine derivatives (6-14). The structures of the prepared compounds have been proved by elemental analysis, IR, 1H  and 13C NMR and mass spectra. Significant antitumor activities in planta were observed for some of the prepared compounds. Atlanta Publishing House LLC 2013-06-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/749 10.5155/eurjchem.4.2.138-145.749 European Journal of Chemistry; Vol. 4 No. 2 (2013): June 2013; 138-145 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/749/PDF