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oai:ojs.www.eurjchem.com:article/751 2013-06-30T03:41:05Z eurjchem:ART driver

Synthesis, characterization and comparative study the antibacterial activities of some imine-amoxicillin derivatives Tomi, Ivan Hameed Rouil Abdullah, Amer Hasan Al-Daraji, Ali Hussein Raheemah Abbass, Selma Abdul Rudha Schiff base Amoxicillin Penicillin A Azomethine Imine derivatives Antibacterial activity In this study, we report the synthesis of some new Schiff base compounds (1-5) from the reaction of amoxicillin with some aromatic aldehydes in classical Schiff base method. These derivatives were characterized by melting point, elemental analysis, FT-IR and 1H NMR data. All the synthesized compounds were evaluated in vitro for their antibacterial activities against two Gram positive (Staphylococcus aureus, Streptococcus faecalis) and two Gram negative (Escherichia coli, Pseudomonas aeruginosa) microorganisms in different concentrations (10-1, 10-3, 10-5 and 10-7 M) by agar diffusion disk method. The results showed that some of these derivatives have good antibacterial activities compared to biological activity of parent drug. Atlanta Publishing House LLC 2013-06-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/751 10.5155/eurjchem.4.2.153-156.751 European Journal of Chemistry; Vol. 4 No. 2 (2013): June 2013; 153-156 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/751/PDF