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oai:ojs.www.eurjchem.com:article/792 2013-12-31T06:16:57Z eurjchem:ART driver

Synthesis and biological evaluation of novel β-hydroxy benzimidazolyl sulfone fluoroquinolones by selective oxidation using ammonium molybdate catalysed H2O2 Guruswamy, Batthini Arul, Rama Krishnan Chaitan, Muggu Venkata Satya Rama Krishna Darsi, Sai Subrahmanya Praveen Kumar Levofloxacin Epichlorohydrine Antimicrobial activity Ammonium molybdate β-Hydroxy benzimidazolyl sulfones Chiral benzoxazole fluoroquinolones Synthesis of new β-hydroxy benzimidazolyl sulfides (4a-e) and β-hydroxy benzimidazolyl sulfones (5a-e) containing 7-piperazine fluoroquinolones have been described and evaluated for their antimicrobial activity. Benzoxazine fluoroquinolone carboxylic acid, 1, on reaction with piperazine in presence of triethylamine in acetonitrile under reflux resulted 7-piperazine bezoxazole fluoroquinolone, 2. The latter is reacted with epichlorohydrine in presence of NaOH in acetone yielded corresponding N-substituted epoxide, 3, with retained chirality, which on treatment with 5-substituted-2-mercaptobenzimidazoles given the corresponding β-hydroxy bezimidazolyl sulfides (4a-e). Further compounds 4a-e on treatment with H2O2 and ammonium molybdate in dichloromethane yielded the β-hydroxy bezimidazolyl sulfones, 5a-e. The antimicrobial activity of newly synthesized compounds along with levofloxacin (reference drug) were evaluated against different microorganisms and found many of the evaluated compounds have been exhibited remarkable activity. Atlanta Publishing House LLC 2013-12-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/792 10.5155/eurjchem.4.4.329-335.792 European Journal of Chemistry; Vol. 4 No. 4 (2013): December 2013; 329-335 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/792/PDF