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oai:ojs.www.eurjchem.com:article/803 2013-12-31T06:16:57Z eurjchem:ART driver

Mixed bivalent transition metal complexes of 1,10-phenanthroline and 2-aminomethylthiophenyl-4-bromosalicylaldehyde Schiff base: Spectroscopic, molecular modeling and biological activities Aljahdali, Mutlaq Shedeed El-Sherif, Ahmed Abdou Hilal, Rifaat Hasan Abdel-Karim, Abeer Taha Schiff base Bivalent metals Biological activity Antitumor activity Electronic spectra Mixed-ligand complexes Mixed ligand complexes of M(II) {M = Cu(II), Ni(II), Co(II) and Zn(II)} with 1,10-phenanthroline (1,10-Phen) and Schiff base namely 2-aminomethylthiophenyl-4-bromosalicylaldehyde (ATS) have been synthesized. These metal chelates have been characterized by elemental analyses, IR, 1H NMR, solid reflectance, magnetic moment and molar conductance. Spectral data showed that the 1,10-phenanthroline act as neutral bidentate ligand coordinating to the metal ion through two nitrogen donor atoms and Schiff base (ATS) acts as monobasic bidentate coordinating through through azomethine-N and phenolic-oxygen groups. The geometry of the studied M(II) complexes has been fully optimized. The metal chelates have been screened for their antimicrobial activities using the disc diffusion method against different selected types of bacteria and fungi. In vitro antitumor activity assayed against two human cell lines colon (HCT116) and larynx (HEP2) cancer cells. Solution equilibrium studies were also investigated. Atlanta Publishing House LLC 2013-12-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/803 10.5155/eurjchem.4.4.370-378.803 European Journal of Chemistry; Vol. 4 No. 4 (2013): December 2013; 370-378 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/803/PDF