2026-05-25T01:31:22Z https://www.eurjchem.com/index.php/eurjchem/oai

oai:ojs.www.eurjchem.com:article/837 2013-09-30T04:22:07Z eurjchem:ART driver

Synthesis and antimicrobial activity of some new 1,2-bis-[1,3-thiazolidin-3-yl]ethane derivatives Dawood, Kamal Mohamed Abu-Deif, Hussein Khalaf-Allah Antifungal Bis-thiourea Antibacterial Alfa-Halo ketones Bis-thiazolidinones 1 3-Thiazolidin-4-one 1,2-Bis-(2-(phenylimino)-4-oxo-1,3-thiazolidin-3-yl)ethane (4) was synthesized and its reaction with various aldehydes afforded the novel 5-arylidene derivatives 5a-e and 7. Reaction of compound 4 with phenyl isothiocyanate in the presence of potassium hydroxide, followed by addition of two equivalents of α-halo ketones furnished the corresponding 1,2-bis-[5-(thiazolidin-2-ylidene)thiazolidin-3-yl]ethane derivatives 10, 14a-c, and 17a,b. The structures of the newly synthesized compounds were established by elemental and spectral analyses. Compounds 5a-e, 7, 10, 14a-c and 17a were screened for their antimicrobial activity against eight microorganisms. All compounds showed high antibacterial and antifungal activities against all the test microorganisms except E. coli and C. albicans. The MIC of the active compounds was also evaluated, where; compounds 10 and 17a were more potent active (minimum inhibitory concentration 0.49 and 0.98 μg/mL, respectively) against S. racemosum than Amphotericin B (MIC 1.95 μg/mL). Atlanta Publishing House LLC 2013-09-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/837 10.5155/eurjchem.4.3.277-284.837 European Journal of Chemistry; Vol. 4 No. 3 (2013): September 2013; 277-284 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/837/PDF