2026-05-04T20:55:35Z https://www.eurjchem.com/index.php/eurjchem/oai

oai:ojs.www.eurjchem.com:article/866 2014-03-31T01:48:51Z eurjchem:ART driver

Synthesis of new benzisoxazole derivatives and their antimicrobial, antioxidant and anti-inflammatory activities Shivaprasad, Chalya Mallappaji Jagadish, Swamy Swaroop, Toreshettahally Ramesh Mohan, Chakrabhavi Dhananjaya Roopashree, Rangaswamy Kumar, Kothanahally Shivaramu Sharath Rangappa, Kanchugarakoppal Subbegowda Piperidine Antioxidant Spirolactone Benzisoxazole Antimicrobial Anti-inflammatory A series of benzisoxazole derivatives were synthesized and evaluated for their antibacterial, antioxidant and anti-inflammatory activities. The results indicated that most of the compounds exhibit moderate antimicrobial activity against Gram negative (Escherichia coli, Klebsiella pneumoniae, Salmonella typhi, Shigella flexineri) and Gram positive (Bacillus subtilis) bacterial culture. The molecules were evaluated for antioxidant activities using 2,2-diphenyl-1-picrylhydrazyl scavenging, super oxide radical scavenging and hydroxyl radical scavenging assays and most of them showed good antioxidant activities. Also, the synthesized compounds were screened for anti-inflammatory activities such as lipoxygenase inhibition and indirect haemolytic assays. Atlanta Publishing House LLC 2014-03-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/866 10.5155/eurjchem.5.1.91-95.866 European Journal of Chemistry; Vol. 5 No. 1 (2014): March 2014; 91-95 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/866/PDF_866