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oai:ojs.www.eurjchem.com:article/916 2014-03-31T01:48:51Z eurjchem:SC driver

1,1-Diphenyl-2-picrylhydrazyl radical scavenging activity of novel dihydropyridine derivatives Anwar, Ayaz Hameed, Abdul Perveen, Shahida Uroos, Maliha Choudhary, Muhammad Iqbal Basha, Fatima Zahra Oxidative stress Antioxidant activity Reactive oxygen species DPPH radical scavengers Knoevenagel condensation Dihydropyridine derivatives Thirteen dihydropyridine analogues 1-13 were synthesized and evaluated for their DPPH radical scavenging activity. A good to moderate antioxidant activity ranging from 127.4 to 284.5 μM was observed and structure-activity relationship was established. The 3'-fluoro derivative 8 (IC50 = 127.4±3.5 μM) was found to exhibit highest activity among the dihydro pyridine derivatives 1-13, while the other derivatives 11 (IC50 = 132.5±3.32 μM), 6 (IC50 = 142.2±0.60 μM), 10 (IC50 = 144.7±2.46 μM), 12 (IC50 = 153.7±0.50 μM), 5 (IC50 = 161.4±2.81 μM) and 5 (IC50 = 164.4±2.50 μM) possess moderate activity, depends upon the C-4 and C-6 substituted groups. The compounds 7, 13, 4, 3 and 2 have lowest IC50 values, ranging between 172.8 and 284.5 μM. Dihydropyridine analogues were characterized by spectroscopic techniques. Atlanta Publishing House LLC 2014-03-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/916 10.5155/eurjchem.5.1.189-191.916 European Journal of Chemistry; Vol. 5 No. 1 (2014): March 2014; 189-191 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/916/PDF_916