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oai:ojs.www.eurjchem.com:article/924 2014-03-31T01:48:51Z eurjchem:ART driver

Microwave assisted synthesis and biological evaluation of a series of 1,5-benzothiazepines as potential cytotoxic and antimicrobial agents Yenupuri, Subhash Hariharan, Agastyaraju Venkata Lakshmi Narasimha Satyanarayana Bugata, Bharat Kumar Nori, Divakara Laxman Somayajulu Cytotoxicity Podophyllotoxin 1 5-Benzothiazepines Antimicrobial activity Brine shrimp lethality Agar well diffusion assay A series of 2,3-dihydro-2-(susbtituted)-4-(1-methyl-1H-pyrrol-2-yl)-1,5-benzothiazepines (4a-v) have been synthesized evaluated for their in vitro cytotoxicity and antimicrobial activities. Among the tested compounds for cytotoxicity using Brine shrimp lethality assay, compound 4q exhibited significant cytotoxicity at ED50 values 3.45±0.15 µg/mL. This level of activity was found comparable to that of the reference drug podophyllotoxin with ED50 value 3.61±0.17 µg/mL. Antimicrobial activity was assessed using agar well diffusion assay method against selected Gram-positive, Gram-negative and fungal strains. Among the compounds tested, 4q, 4r and 4l were found to be more active with MIC 16-32 µg/mL against all tested microorganisms. Atlanta Publishing House LLC 2014-03-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/924 10.5155/eurjchem.5.1.138-143.924 European Journal of Chemistry; Vol. 5 No. 1 (2014): March 2014; 138-143 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/924/PDF_924