2026-04-10T05:31:15Z https://www.eurjchem.com/index.php/eurjchem/oai

oai:ojs.www.eurjchem.com:article/990 2014-06-30T08:07:06Z eurjchem:ART driver

Characterization and biological activity studies on some transition metal complexes of thiosemicarbazide derived from 2-picolinic acid hydrazide Mohamed, Eshraga Eltayeb AbedelKarim, Abeer Taha Elmalik, Yahia Hassan Mohamed, Amna Elamin Aljahdali, Mutlaq Sheeded Complex Antifungal Picolinic acid Antibacterial Thiosemicarbazone Molecular modeling Mixed-ligand bivalent transition metal ion complexes with N-ethyl-2-picolinoyl hydrazinecarbothioamide (EPHC) and 1,10-phenanthroline (1,10-phen) have been synthesized. The complexes namely [Cu(EPHC)(1,10-phen)(Cl)H2O] (1), [Ni(EPHC)(1,10-phen)(Cl)H2O] (2), [Mn(EPHC)(1,10-phen)(Cl)H2O] (3) and [Co(EPHC)(1,10-phen)(Cl)H2O] (4) were characterized by elemental analysis, spectral (IR, 1H NMR and UV-Vis) and magnetic moment measurements. The magnetic and spectral data indicates octahedral structure for all complexes. Metal complexes have been modeled using parameterized PM3 semi-empirical method. The free ligand and its M(II)-chelates have been screened for their antimicrobial activities. The antibacterial screening demonstrated that, the Cu(II) complex have the maximum and broad activities among the investigated complexes. Atlanta Publishing House LLC 2014-06-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/990 10.5155/eurjchem.5.2.252-259.990 European Journal of Chemistry; Vol. 5 No. 2 (2014): June 2014; 252-259 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/990/pdf_990