2026-04-26T10:53:34Z https://www.eurjchem.com/index.php/eurjchem/oai

oai:ojs.www.eurjchem.com:article/1 2011-04-05T15:59:16Z eurjchem:ART driver

Synthesis and studying the antitumor activity of novel 5-(2-methylbenzimidazol-5-yl)-1,3,4-oxadiazole-2(3H)-thiones Galal, Shadia Ahmed Abdelsamie, Ahmed S. Rodriguez, Mireya L. Kerwin, Sean M. El Diwani, Hoda I. Salicylate Hydrogen bonding DFT-Molecular dynamics Vibrational spectroscopy Relaxation spectroscopy The influence of the incorporation of 1,3,4-oxadiazole ring into 2-methyl-1H-benzimidazole derivatives producing a series of substituted 5(6)-(2-methylbenzimidazol-5-yl)-1,3,4-oxadiazoles on the antitumor activity was studied in this study. The antitumor activity of the new compounds was tested against breast cancer cell line MCF-7 and lung cancer cell line A549. S-5-(2-methyl-1H-benzo[d]imidazol-5-yl)-1,3,4-oxadiazol-2-yl 2-nitrobenzenesulfonothioate (9) showed potent activity against both MCF-7 and A549 cell lines. Whereas, compounds 7, 11-13 and 15-17 have moderate growth inhibitory activity on the two cell lines. Atlanta Publishing House LLC 2010-06-15 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/1 10.5155/eurjchem.1.2.67-72.1 European Journal of Chemistry; Vol. 1 No. 2 (2010): June 2010; 67-72 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/1/PDF

oai:ojs.www.eurjchem.com:article/2 2011-04-05T14:39:41Z eurjchem:REW driver

1,4-Diazabicyclo[2.2.2]octane (DABCO) as a useful catalyst in organic synthesis Bita, Baghernejad DABCO 1 4-diazabicyclo[2.2.2]octane Organic reactions 1,4-diazabicyclo[2.2.2]octane (DABCO) has been used in many organic preparations as a good solid catalyst. DABCO has received considerable attention as an inexpensive, eco-friendly, high reactive, easy to handle and non-toxic base catalyst for various organic transformations, affording the corresponding products in excellent yields with high selectivity. In this review, some applications of this catalyst in organic reactions were discussed. Atlanta Publishing House LLC 2010-03-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/2 10.5155/eurjchem.1.1.54-60.2 European Journal of Chemistry; Vol. 1 No. 1 (2010): March 2010; 54-60 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/2/PDF

oai:ojs.www.eurjchem.com:article/3 2019-12-31T10:26:43Z eurjchem:ART driver

Theoretical and experimental studies on N-(6-methylpyridin-2-yl-carbamothioyl)biphenyl-4-carboxamide Yesilkaynak, Tuncay Binzet, Gun Emen, Fatih Mehmet Flörke, Ulrich Külcü, Nevzat Arslan, Hakan Thiourea Single crystal X-ray diffraction Ab-initio calculations DFT A novel thiourea derivative, N-(6-methylpyridin-2-yl-carbamothioyl)biphenyl-4-carbox amide, is synthesized and characterized by elemental analysis, FT-IR, NMR and single crystal X-ray diffraction study. There are two independent molecules A and B in the asymmetric unit. The short bond lengths of the C-N bonds in the central thiourea fragment indicate partial double bond character in this fragment of the title compound. These results can be explained by the existence of resonance in this part of the molecule. Each A and B molecule is stabilized with an intramolecular N-H•••O hydrogen bond which results in the formation of a pseudo six membered ring. In addition, the independent molecules are linked into a chain along the c axis by weak N-H•••S intermolecular hydrogen bonds. The conformational behavior and structural stability of the optimized geometry of the title compound were also investigated by utilizing ab- initio calculations with 6-31G* basis set at HF, BLYP, and B3LYP levels. The calculated parameters are in good agreement with the corresponding X-ray diffraction values. Atlanta Publishing House LLC 2010-03-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/3 10.5155/eurjchem.1.1.1-5.3 European Journal of Chemistry; Vol. 1 No. 1 (2010): March 2010; 1-5 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/3/PDF

oai:ojs.www.eurjchem.com:article/4 2011-04-05T14:39:15Z eurjchem:ART driver

Facile synthesis and cytotoxic activity of 3,6-disubstituted 1,2,4-triazolo-[3,4-b]-1,3,4-thiadiazoles Ilango, Kaliappan Valentina, Parthiban Triazole Thiadiazole Triazolo-[3 4-b]-1 3 4-thiadiazoles Cytotoxic Afacile synthesis of 3,6-disubstituted-1,2,4-triazolo-[3,4-b]-1,3,4-thiadiazoles (5a-j) has been achieved by condensing 3-aryl substituted 4-amino-5-mercapto (4H)-1,2,4-triazole (4a-b) with various aromatic acids. The structures of the synthesized compounds were supported by IR, 1H NMR, mass spectral data and elemental analysis The compounds were evaluated for in vitro cytotoxic activity against four human cancer cell lines: two ovarian (PA-1and OAW-42) and two breast (T47D and MCF-7) cell lines using the methyl thiazol tetrazolium assay method. It showed that some of the tested compounds 5a, 5b, 5g and 5f exhibited significant activity against PA-1 cell lines and the compounds 5a and 5e exhibited IC50 of 0.72 µM and 0.65 µM, respectively, against the cell lines of MCF-7, which are close to Doxorubin. After comparing the cytotoxic activity results of compounds 5a-j, it was concluded that the incorporation of triazolo-thiadiazole moiety in aryl propionic acid group gives rise to enhanced anticancer activity. Also, the substitution of chloro group in the aryl ring at the 3rd position was found to enhance their potency. Atlanta Publishing House LLC 2010-03-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/4 10.5155/eurjchem.1.1.50-53.4 European Journal of Chemistry; Vol. 1 No. 1 (2010): March 2010; 50-53 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/4/PDF

oai:ojs.www.eurjchem.com:article/5 2011-04-05T14:36:30Z eurjchem:ART driver

Synthesis of some novel Schiff bases containing 1,2,4-triazole ring Mobinikhaledi, Akbar Foroughifar, Naser Khanpour, Mansooreh Ebrahimi, Sattar 1 2 4-triazole Schiff bases Acetohydrazide Synthesis Heterocyclic compounds 4-Allyl-5-piridine-4-yl-4H-1,2,4-triazole-3-thiol was prepared under facile condition via the formation of 2-isonicotinoyl-N-allylhydrazinecarbothioamide. In addition, ethyl[(4-allyl-5-pyridine-4-yl-4H-1¸2¸4-triazole-3-yl)thio]acetate was synthesized via the reaction of 4-allyl-5-piridine-4-yl-4H-1,2,4-triazole-3-thiol with ethyl chloroacetate. 2-[(4-Allyl-5-pyridine-4-yl-4H-1,2,4-triazole-3-yl)thio]acetohydrazide obtained by using ethyl[(4-allyl-5-pyridine-4-yl-4H-1¸2¸4-triazole-3-yl)thio]acetate as a precursor by two steps, was converted to Schiff base derivatives, 6a-j. All synthesized compounds were characterized by elemental analyses, IR spectroscopy, 1H NMR and 13C NMR spectroscopy. The cis/trans conformers of E isomer were present in DMSO solution of compounds 6a-j. Atlanta Publishing House LLC 2010-03-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/5 10.5155/eurjchem.1.1.33-36.5 European Journal of Chemistry; Vol. 1 No. 1 (2010): March 2010; 33-36 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/5/PDF

oai:ojs.www.eurjchem.com:article/6 2011-04-05T14:34:20Z eurjchem:ART driver

Trans-3,5-dihydroperoxy-3,5-dimethyl-1,2-dioxolane as a novel and efficient reagent for selective sulfoxidation of sulfides under catalyst-free condition Azarifar, Davood Khosravi, Kaveh Sulfides Sulfoxides Sulfoxidation Catalyst-Free Condition Application of trans-3,5-dihydroperoxy-3,5-dimethyl-1,2-dioxolane as an efficient and high-oxygen content reagent in selective oxidation of sulfides into sulfoxides has been successfully explored. The reactions proceeded under mild and catalyst-free conditions in dichloromethane at room temperature to provide the sulfoxides in excellent yields without any significant over-oxidation to sulfones. Atlanta Publishing House LLC 2010-03-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/6 10.5155/eurjchem.1.1.15-19.6 European Journal of Chemistry; Vol. 1 No. 1 (2010): March 2010; 15-19 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/6/PDF

oai:ojs.www.eurjchem.com:article/7 2011-04-05T14:38:50Z eurjchem:ART driver

Study on distribution coefficient of bromide ions from aqueous solution on ion exchange resins Indion-850, Indion-860 and Indion FF-IP Singare, Pravin Lokhande, Ram Patil, Vinayak Prabhavalkar, Tirtha Tiwari, Santoshi Ion exchange resin Distribution Coefficient Indion-850 Indion-860 Indion FF-IP The ion exchange resin Indion-850, Indion-860 and Indion FF-IP, in bromide form were equilibrated separately with the labeled radioactive bromide ion solution of different concentrations varying from 0.005 M to 0.100 M in the temperature range of 25.0 oC to 45.0 oC. The Kd values of bromide ions were observed to be high for Indion-850 and least for Indion 860, while Indion FF-IP shows intermediate Kd values under identical experimental conditions. The difference in Kd values of bromide ions for the three resins is mainly because of the swelling pressure which depends on their water holding capacities. Atlanta Publishing House LLC 2010-03-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/7 10.5155/eurjchem.1.1.47-49.7 European Journal of Chemistry; Vol. 1 No. 1 (2010): March 2010; 47-49 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/7/PDF

oai:ojs.www.eurjchem.com:article/8 2011-04-05T14:36:01Z eurjchem:ART driver

Synthesis, characterization and luminescence properties of long afterglow Phosphor Ba4Al14O25:Eu,Dy Emen, Fatih Mehmet Külcü, Nevzat Yazıcı, Ahmet Necmeddin Phosphorescence Aluminates Afterglow Phosphors Optical Materials Long persistent afterglow phosphor, Ba4Al14O25:Eu2+,Dy3+ was prepared at high temperature by a solid state reaction in a weak reductive atmosphere. The crystal structure of Ba4Al14O25:Eu2+,Dy3+ has been determined as an orthorhombic Pmmm space group with a=18.200(6) Å, b=16.923(6) Å, c=5.131(21) Å, V=1580.3(9) Å3 and Z=8. The reflectance measurement was obtained by using the Diffuse Reflectance Spectrophotometer and the band gap energy of the undoped host phase of Ba4Al14O25 was calculated by using Kubelka-Munk treatment on the diffuse reflectance spectra, and found to be 4.72 eV. The excitation and emission peaks are broad bands and the main emission peak at 520 nm with shoulder at 496 nm belongs to the intrinsic defect of the host and 4f65d1→4f7 transition of Eu2+, respectively. The afterglow decay curve implied that this phosphor contains fast and slow-decay processes. The thermoluminescence glow curve showed one dominant glow peak observed at 50 oC and two weak glow peaks at around 140 oC and 220 oC which are related to the defects at different trap depths. Atlanta Publishing House LLC 2010-03-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/8 10.5155/eurjchem.1.1.28-32.8 European Journal of Chemistry; Vol. 1 No. 1 (2010): March 2010; 28-32 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/8/PDF

oai:ojs.www.eurjchem.com:article/9 2011-04-05T14:33:24Z eurjchem:ART driver

Biotechnological treatment of effluent from the combined enzymatic-ultrasound scouring of raw wool Yordanov, Dancho Betcheva, Rositza Yotova, Lubov Wool scouring effluent Aerobic treatment Anaerobic treatment Clean technology Activated-sludge Enzyme New eco-labels for textile products and demands to wastewater discharges are forcing wool scouring processes to reuse wastewater and to search for more efficient and environmental friendly methods of processing. This challenge has prompted intensive research in new advanced treatment technologies. Due to the high level of detergent usage, the most widely used treatment of wool scouring effluent (WSE) is anaerobic. As the pressure to use more environmentally acceptable treatment methods increases there is the need to study alternative, biologically efficient treatment systems for WSE. This work aims at studying the influence of the combined enzymatic-ultrasound scouring of raw wool fibers on the effectiveness of the anaerobic treatment of effluents from this processing. Experiments carried out combined enzyme and ultrasound scouring of wool followed by treatment of effluents obtained. Aerobic and anaerobic treatments of these effluents were performed using a special laboratory reactor. Chemical oxygen demand (COD) and biochemical oxygen demand (BOD) of effluents from different scouring processes were defined. The results of this study indicate that the anaerobic biological and chemical treatments of WSE treated by combined enzymatic-ultrasound scouring is a promising alternative technology from the point of view of reducing the wastewater pollution and the effective cleaning of effluents coming out from this process. Atlanta Publishing House LLC 2010-03-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/9 10.5155/eurjchem.1.1.12-14.9 European Journal of Chemistry; Vol. 1 No. 1 (2010): March 2010; 12-14 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/9/PDF

oai:ojs.www.eurjchem.com:article/10 2012-09-30T06:32:52Z eurjchem:ART driver

Ab initio and density functional theory studies on vibrational spectra of 3-{[(4-methoxyphenyl)methylene]amino}-2-phenylquinazolin-4(3H)-one Panicker, Chacko Yohannan Varghese, Hema Tresa Ambujakshan, Kalappat Raman Mathew, Samuel Ganguli, Subarna Nanda, Ashis Kumar Alsenoy, Christian Van Yohannan, Sheena Mary Quinazoline IR Spectra Raman Spectra DFT calculations PED The infrared and Raman spectra of 3-{[(4-methoxyphenyl)methylene]amino}-2-phenylquinazolin-4(3H)-one have been recorded and analysed. Geometry and harmonic vibrational wavenumbers were calculated theoretically using Gaussian 03 set of quantum chemistry codes. Calculations were performed at the Hartree-Fock and DFT (B3LYP) levels of theory using the standard 6-31G* basis. The calculated wavenumbers (B3LYP) agree well with the observed wavenumbers. The proposed assignments of normal modes are based on potential energy distribution (PED) analysis. Calculated infrared intensities and first hyperpolarizability are reported. The prepared compound was identified by NMR and mass spectra. The phenyl C-C stretching modes are equally active as strong bands in both IR and Raman spectra, which are responsible for hyperpolarizability enhancement leading to nonlinear optical activity. The calculated first hyperpolarizability is comparable with the reported values of similar structures and is an attractive object for further studies of non linear optics.  Atlanta Publishing House LLC 2010-03-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/10 10.5155/eurjchem.1.1.37-43.10 European Journal of Chemistry; Vol. 1 No. 1 (2010): March 2010; 37-43 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/10/PDF

oai:ojs.www.eurjchem.com:article/11 2011-04-05T14:48:33Z eurjchem:ART driver

Identification of degradation products in Aripiprazole tablets by LC-QToF mass spectrometry Reddy, Gosula Venkat Rami Kumar, Avvaru Praveen Reddy, Bobba Venkateswara Kumar, Poonam Gauttam, Ham Dutt Aripiprazole Identification of degradation impurities LC-QToF-MS HPLC This paper describes the separation, identification and proposed structures of the degradation products formed during degradation analysis of aripiprazole in its final dosage form by high performance liquid chromatography (HPLC) coupled with quadrupole time-of-flight mass spectrometry (QToF-MS). The drug product was subjected to stress conditions including acid, base, thermal, oxidation, humidity and photolytic degradations. Aripiprazole was found to be stable in all conditions except in thermal and peroxide degradations. The degradation impurities were first separated by HPLC and then identified using QToF mass spectrometry. QToF mass spectrometer provided high order of mass accuracy for unknown impurities and their fragment ions to explore the elemental composition. Based on the fragmentation pattern, the possible structures of the unknown impurities were proposed. To the best of our knowledge, there were no methods available to identify the impurities during degradation of aripiprazole tablets by liquid chromatography-mass spectrometry. Atlanta Publishing House LLC 2010-03-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/11 10.5155/eurjchem.1.1.20-27.11 European Journal of Chemistry; Vol. 1 No. 1 (2010): March 2010; 20-27 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/11/PDF

oai:ojs.www.eurjchem.com:article/12 2011-04-05T14:32:49Z eurjchem:ART driver

Synthesis and antimicrobial activity of some new 1,3-thiazoles, 1,3,4-thiadiazoles, 1,2,4-triazoles and 1,3-thiazines incorporating acridine and 1,2,3,4-tetrahydroacridine moieties Ali, Tarik El-Sayed El-Kazak, Azza Mohammed Acridine 1 2 3 4-Tetrahydroacridine S N-heterocycles Antimicrobial Activity Some new sulfur-nitrogen heterocyclic systems such as 1,3-thiazoles, 1,3,4-thiadiazoles, 1,2,4-triazoles and 1,3-thiazines incorporating acridine and 1,2,3,4-tetrahydroacridine moieties were synthesized via heterocyclization of the key intermediate 4-(acridin-9-yl)-1-(1,2,3,4-tetrahydroacridin-9-ylcarbonyl)thiosemicarbazide. Structures of the new comp-ounds were established by elemental analyses and spectral data. All the products were also screened in vitro for their antimicrobial activity. Atlanta Publishing House LLC 2010-03-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/12 10.5155/eurjchem.1.1.6-11.12 European Journal of Chemistry; Vol. 1 No. 1 (2010): March 2010; 6-11 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/12/PDF

oai:ojs.www.eurjchem.com:article/13 2019-11-15T08:35:46Z eurjchem:ART driver

Effect of calcitonin on lipid peroxidation in ovariectomized rats Berkoz, Mehmet Yalin, Serap Comelekoglu, Ulku Bagis, Selda Osteoporosis oxidative stress antioxidant ovariectomy calcitonin Calcitonin is one of the active substances which is recently used effectively in osteoporosis treatment. In literature there is no information whether calcitonin cause oxidative stress or not. In this study, subcutaneous calcitonin is applied to rats having experimental postmenopausal osteoporosis and the effects of calcitonin on lipid peroxidation and antioxidant system were investigated. Forty-five healthy adult female Swiss albino Wistar rats were used in this study. The rats were divided into three equal groups as control, ovariectomized (Ovx) and ovariectomized+calcitonin (Ovx-CAL). The rats in Ovx and Ovx-CAL were anaesthetized and underwent a bilateral ovariectomy via ventral incision. Ten weeks after ovariectomy, salmon calcitonin (2 IU/kg body weight) was administered via s.c. at a volume of 1 mL per week for 12 weeks to the Ovx-CAL group. At the end of the drug treatment, livers and kidneys of rats were removed and malondialdehyde (MDA) levels and catalase (CAT) activities were determined by biochemical analysis methods. Data were analyzed by one-way ANOVA followed by the post-hoc LSD multiple test. The liver and kidney MDA levels were increased whereas the activity of CAT enzyme was decreased as a result of ovariectomy compared to values in the control group. Similar results were observed in Ovx-CAL group; however, the decline in the CAT activity in the kidney was not significant. In conclusion, we may suggest that calcitonin treatment increases the oxidative stress in osteoporotic rats. Atlanta Publishing House LLC 2010-03-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/13 10.5155/eurjchem.1.1.44-46.13 European Journal of Chemistry; Vol. 1 No. 1 (2010): March 2010; 44-46 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/13/PDF

oai:ojs.www.eurjchem.com:article/17 2011-04-06T05:19:10Z eurjchem:SC driver

A new natural pyrrolone from the Egyptian Ageratum species Hussien, Taha Abdelrahim Mohamed, Naglaa Salah-Eldin Moustafa, Mahmoud F.M. El-Sayed, Magdi Abdelradi Ageratum conyzoides Asteraceae Pyrrolone Ageratum conyzoides L., is an annual herb with a long history of traditional medicinal uses in many countries in the world, especially in the tropical and subtropical regions. A wide range of chemical compounds including alkaloids, flavonoids, chromenes, benzofurans and terpenoids have been isolated from this species. Extracts and metabolites from this plant have been found to possess pharmacological and insecticidal activities. In continuation of our interest in the Egyptian medicinal plants, the reinvestigation of the methylenechloride extract of the air-dried aerial parts of Ageratum conyzoides afforded a new natural compound 1, pyrrolone, 5-ethoxy-1H-pyrrol-2(5H)-one, together with a known flavonoid. The structures of the compounds were determined by comprehensive NMR studies, including DEPT, COSY, HMQC, HMBC, and MS. Atlanta Publishing House LLC 2010-06-15 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/17 10.5155/eurjchem.1.2.140-141.17 European Journal of Chemistry; Vol. 1 No. 2 (2010): June 2010; 140-141 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/17/PDF

oai:ojs.www.eurjchem.com:article/20 2011-04-06T05:44:40Z eurjchem:ART driver

Synthesis and bioactivity of phosphorylated derivatives of stavudine Rao, Alahari Janardhan Rao, Valasani Koteswara Rao, Pasupuleti Visweswara Raju, Chamarthi Naga Ghosh, Sunil Kumar Phosphorylated derivatives of stavudine Gram-positive bacteria Gram-negative bacteria Antibacterial activity Antioxidant activity Novel phosphorylated derivatives of stavudine were synthesized by the reaction of bis(2-chloroethyl)phosphoramidic dichloride/4-nitrophenyl phosphorodichloridate with various cyclic amines and amino acid esters in the presence of triethylamine in dry tetrahydrofuran through the corresponding monochloride intermediates 2a-l. Further reaction of the intermediates 2a-l with stavudine in tetrahydrofuran and pyridine in the presence of triethylamine formed the title compounds 4a-l. Their structures were characterized by IR,   1H-, 13C-, 31P-NMR and mass spectral data analyses. They exhibited good antibacterial and antioxidant activities. Their bioactivity was greatly influenced by the different groups present at the phosphorus. Atlanta Publishing House LLC 2010-12-22 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/20 10.5155/eurjchem.1.4.297-301.20 European Journal of Chemistry; Vol. 1 No. 4 (2010): December 2010; 297-301 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/20/PDF

oai:ojs.www.eurjchem.com:article/23 2011-04-06T05:25:03Z eurjchem:ART driver

On the Structure of Liquid Methyl Salicylate: the Role of Intramolecular Hydrogen Bonding Aparicio, Santiago Alcalde, Rafael Salicylate Hydrogen bonding DFT-Molecular dynamics Vibrational spectroscopy Relaxation spectroscopy A study on the structure of methyl salicylate is reported using quantum mechanical calculations, molecular dynamics simulations, vibrational spectroscopy and microwave dielectric relaxation spectroscopy tools. The reported results show that a strong intramolecular hydrogen bonding is developed between the hydroxyl hydrogen and carbonyl oxygen. This intramolecular interaction is maintained in gas and liquid phases and even when diluted in inert solvents. Interaction between neighbour molecules is developed through dipolar interactions, and thus, intermolecular hydrogen bonding should be discarded for pure liquid methyl salicylate. The interaction between neighbour methyl salicylate molecules do not lead to remarkable changes in the intramolecular hydrogen bonding. Atlanta Publishing House LLC 2010-09-29 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/23 10.5155/eurjchem.1.3.162-167.23 European Journal of Chemistry; Vol. 1 No. 3 (2010): September 2010; 162-167 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/23/PDF

oai:ojs.www.eurjchem.com:article/24 2010-03-31T20:27:08Z eurjchem:EDI driver

Welcome to European Journal of Chemistry Arslan, Hakan On behalf of the editorial team, welcome to European Journal of Chemistry. European Journal of Chemistry is a recently established journal publishing original research papers, reviews and technical notes on the topics of Analytical Chemistry, Inorganic Chemistry, Organic and Bioorganic Chemistry, Biochemistry, Theoretical and Applied Physical Chemistry, Pharmaceutical Chemistry, Applied and Materials Chemistry, Chemical Technology, Agro Chemical Technology, Pharmaceutical Technology, Colloid Chemistry, Interfacial Chemistry, Surface Chemistry, Chemical Engineering, Green Chemistry, etc.Our aim is to encourage scientists to publish their theoretical and experimental details, while interacting and exchanging valuable information with each other.European Journal of Chemistry is an Open Access Journal. The published articles in European Journal of Chemistry are freely accessible via the Internet for immediate worldwide, open access to the full text of research articles for the best interests of the scientific community. All interested readers can read, download, and print any Open Access article at no cost. There are no subscription fees for European Journal of Chemistry.This journal accepts original research and review papers as well as letters in all areas of chemistry. A manuscript submitted to the journal for publication should be original. It should not have been previously published and should not be under consideration for publication elsewhere. All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymised refereeing by at least two expert reviewers. Authors are encouraged to suggest referees for their work. The journal is published print and online and articles are available as online rapidly after acceptance. The published articles are expected to receive high citations as the journal develops and reaches prominence in the field.I expect that European Journal of Chemistry will attract manuscripts of the highest quality which are of the greatest possible benefit to readers. We look forward to receiving your submissions. Please do not hesitate to contact the Editor, if you would like to discuss the suitability of your contribution to European Journal of Chemistry.Dr. Hakan ArslanFounding and Editor-in-ChiefEuropean Journal of Chemistrywww.eurjchem.com Atlanta Publishing House LLC 2010-03-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Editorial application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/24 10.5155/eurjchem.1.1.i-ii.24 European Journal of Chemistry; Vol. 1 No. 1 (2010): March 2010; i-ii 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/24/PDF

oai:ojs.www.eurjchem.com:article/25 2010-03-31T16:54:59Z eurjchem:EDI driver

Guide for Authors Arslan, Hakan Guide for Authors Atlanta Publishing House LLC 2010-03-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Editorial application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/25 10.5155/eurjchem.1.1.iii-v.25 European Journal of Chemistry; Vol. 1 No. 1 (2010): March 2010; iii-v 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/25/PDF

oai:ojs.www.eurjchem.com:article/26 2011-04-06T05:13:30Z eurjchem:ART driver

Evaluation of global hardness of atoms based on the commonality in the basic philosophy of the origin and the operational significance of the electronegativity and the hardness. Part I. The Gordy’s scale of electronegativity and the G.H. Islam, Nazmul Ghosh, Dulal C. Commonality between electronegativity and hardness Gordy scale of electronegativity Scale of global hardness based on potential concept Periodicity of global hardness of atoms Relying upon the fact that the hardness, like the electronegativity, is a qualitative property and there is commonality in the basic philosophy of the origin and the operational significance of these two fundamental descriptors of atoms in physics and chemistry, we have proposed to use the Gordy's ansatz, modified by Ghosh and Chakraborty, of evaluating electronegativity of atoms as the ansatz of measuring the global hardness of atoms in this work. The ansatz under reference computes the energy of attraction between the screened nucleus of the atoms and its valence electrons. This is our definition of electronegativity and global hardness of atoms. The evaluated new set of global hardness is found to satisfy the sine qua non of a reasonable scale of hardness by exhibiting perfect periodicity of periods and groups and correlating the gross physico-chemical properties of elements. The inertness of Hg and extreme reactivity of Cs and Fr atoms are nicely correlated. The chemical reactivity and its variation in small steps in the series of lanthanide elements are also nicely reproduced. The results of the present semi-empirical calculation find strong correlation with the results of some sophisticated DFT calculations for a set of atoms. Atlanta Publishing House LLC 2010-06-15 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/26 10.5155/eurjchem.1.2.83-89.26 European Journal of Chemistry; Vol. 1 No. 2 (2010): June 2010; 83-89 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/26/PDF

oai:ojs.www.eurjchem.com:article/29 2011-04-06T05:25:30Z eurjchem:ART driver

Synthesis and antimicrobial evaluation of some new polyheterocyclic systems containing 1,2,4-triazine moiety Abdel-Monem, Wafaa Ramzy 1 2 4-Triazine 4-Triazole Imidazole Polyheterocyclic nitrogen systems Antimicrobial activity 7-(4-Chloro/3-nitrophenyl)-8-[5,6-diphenyl-4-(1,3-thiazol-2-yl)-1,4-dihydro-1,2,4-triazin-3-yl]-5-oxo-1,5-dihydro[1,2,4]triazolo[1,5-a]pyridine-6-carbonitrile (6a, b) was utilized as a key intermediate for the target polyheterocyclic systems. Reactions of 6a, b with halocarbonyl reagents followed by heterocyclization with bi-nitrogen nucleophiles gave some new nitrogen heterocycles (7-13). Structures of the new compounds were established by elemental analyses and spectral data. The synthesized compounds were screened for their antimicrobial activity. Atlanta Publishing House LLC 2010-09-29 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/29 10.5155/eurjchem.1.3.168-172.29 European Journal of Chemistry; Vol. 1 No. 3 (2010): September 2010; 168-172 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/29/PDF

oai:ojs.www.eurjchem.com:article/32 2011-04-06T05:13:54Z eurjchem:ART driver

Synthetic applications of benzothiazole containing cyanoacetyl group Fadda, Ahmed Ali Abdelrazek, Fathy Mohamed Mohamed, Khaled Samir Ghieth, Howayda Mohamed Mostafa Etman, Hassan Ali Benzothiazole Pyridopyrimidine Thienopyridine Oxazole Chromenopyridine Diazepinone derivatives The reactions of 2-(benzo[d]thiazol-2-yl)-3-oxopentanedinitrile with a variety of reagents have been investigated aiming to explore the synthetic potentialities of this activated nitrile in heterocyclic synthesis. Several novel pyridopyrimidine, chromenopyridine, oxazole, diazepinone, thiophene and thienopyridine derivatives could be obtained starting from 2-(benzo[d]thiazol-2-yl)-3-oxopentanedinitrile and plausible mechanisms for their formations are reported. Atlanta Publishing House LLC 2010-06-15 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/32 10.5155/eurjchem.1.2.90-95.32 European Journal of Chemistry; Vol. 1 No. 2 (2010): June 2010; 90-95 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/32/PDF

oai:ojs.www.eurjchem.com:article/34 2011-04-05T16:00:52Z eurjchem:ART driver

Synthesis, characterization and crystal structure of 1-(4-methylbenzoyl)-3-(4 aminosulfonylphenyl)thiourea Saeed, Aamer Mumtaz, Amara Florke, Ulrich Thiourea Sulfonyl thiourea Single crystal X-ray diffraction An efficient synthesis of the title compound, 1-(4-methylbenzoyl)-3-(4-aminosulfonyl phenyl)thiourea,  was carried out by reaction of 4-methylbenzoyl chloride with potassium thiocyanate in acetone to afford 4-methylbenzoyl isothiocyanate in situ followed by treatment with sulfanilamide. The structure was confirmed by spectroscopic data and elemental analyses. The molecular structure was determined from single crystal X-ray diffraction data. It crystallizes in the monoclinic space group P21/n with unit cell dimensions of a = 4.8116(9) Å, b = 17.150(3) Å, c = 18.677(3) Å, γ = 96.487(4) °, and V = 1531.4(5) Å3. Atlanta Publishing House LLC 2010-06-15 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf application/octet-stream https://www.eurjchem.com/index.php/eurjchem/article/view/34 10.5155/eurjchem.1.2.73-75.34 European Journal of Chemistry; Vol. 1 No. 2 (2010): June 2010; 73-75 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/34/PDF https://www.eurjchem.com/index.php/eurjchem/article/view/34/2519

oai:ojs.www.eurjchem.com:article/42 2011-04-06T05:25:52Z eurjchem:ART driver

FT-IR, FT-Raman and ab-initio studies of 1,3-diphenyl thiourea Panicker, Chacko Yohannan Varghese, Hema Tresa George, Abraham Thomas, Puthenveettil Kandathil Varkey FT-IR FT-Raman Thiourea DFT Hyperpolarizability The FT-IR and FT-Raman spectra of 1,3-diphenyl thiourea were recorded and analyzed. The vibrational wavenumbers were examined theoretically with the aid of the Gaussian03 package of programs using the HF/6-311++G(d,p) and B3LYP/6-311++G(d,p) levels of theory. The data obtained from vibrational wavenumber calculations are used to assign vibrational bands obtained in IR and Raman spectroscopy of the studied molecule. The first hyperpolarizabililty, infrared intensities and Raman activities are reported. The calculated first hyperpolarizability is comparable with the reported values of similar derivatives and is an attractive object for future studies of non-linear optics. The geometrical parameters of the title compound are in agreement with the values of similar structures. The changes in the C-N bond lengths suggest an extended π-electron delocalization over the thiourea moiety which is responsible for the non-linearity of the molecule. Atlanta Publishing House LLC 2010-09-29 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/42 10.5155/eurjchem.1.3.173-178.42 European Journal of Chemistry; Vol. 1 No. 3 (2010): September 2010; 173-178 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/42/PDF

oai:ojs.www.eurjchem.com:article/44 2011-04-06T05:26:18Z eurjchem:ART driver

A new three dimensional proton transfer compound including citric acid and 2,4,6-triamine-1,3,5-triazine: synthesis, characterization and X-ray crystal structure Eshtiagh-Hosseini, Hossein Mahjoobizadeh, Milad Mirzaei, Masoud Fromm, Katharina Crochet, Aurelien Proton transfer compound X-ray crystal structure 2 4 6-Triamino-1 3 5-triazine Citric acid π−π Stacking A new three dimensional proton transfer compound, (tataH)2(citH).2H2O (I) was synthesized from the reaction of citric acid (citH3), and 2,4,6-triamino-1,3,5-triazine (tata). The characterization was performed using elemental analysis, IR spectroscopy, and single crystal X-ray structure determination. The crystal structure of the title compound consists of bis-2,4,6-triamino-1,3,5-triazin-1-ium cations, hydrogen citrate, and lattice water molecules. Intermolecular O-H•••O, N-H•••O, and N-H•••N hydrogen bonding interactions stabilize the crystal structure. The hydrogen bonds distances range from of 1.781 to 2.088 Å. The π-π stacking (centroid-centroid ranges 3.410-3.504 Å) between two aromatic rings of tata moieties can play an essential role in the creation and stabilization of the title crystalline network. Atlanta Publishing House LLC 2010-09-29 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/44 10.5155/eurjchem.1.3.179-181.44 European Journal of Chemistry; Vol. 1 No. 3 (2010): September 2010; 179-181 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/44/PDF

oai:ojs.www.eurjchem.com:article/47 2011-04-06T05:14:38Z eurjchem:ART driver

Synthesis and preliminary biological screening of certain 5-aralkyl pyrrolidine-3-carboxylic acids as anticonvulsants Aboul-Enein, Mohamed Nabil El-Azzouny, Aida Abd El-Sattar Saleh, Ola Ahmed Nawwar, Mahmoud Abd El-Moien Ismail, Mohamed Abd El-Hamid Elsedeek, Mahmoud Gamal El-Din Maklad, Yousreya Aly Synthesis 5-aralkyl pyrrolidine-3-carboxylic acids Epilepsy Anticonvulsants Synthesis of a series of 5-aralkyl pyrrolidine-3-carboxylic acid derivatives namely, 1-acetyl-4-hydroxy-5-benzyl or 5-(4-alkoxy-benzyl)-pyrrolidine-3-carboxylic acids (3a-e), 1-H-4-hydroxy-5-benzyl or 5-(4-alkoxy-benzyl)-pyrrolidine-3-carboxylic acids (4a-e), 1-acetyl-5-benzyl or 5-(4-alkoxy-benzyl)-pyrrolidine-3-carboxylic acids (8a-e), 1-H-5-benzyl or 5-(4-alkoxy-benzyl)-pyrrolidine-3-carboxylic acids (9a-e) have been accomplished. The structures of the new compounds were assigned from IR, 1H NMR, 13C NMR and elemental analyses. Compounds 3a-e, 4a-e, 8a-e and 9a-e were biologically screened for their anticonvulsant potential using the subcutaneous pentylenetetrazole seizures (scPTZ) assay and Gabapentin as reference standard. The 1-H-4-hydroxy-5-benzyl or 5-(4-alkoxy-benzyl)-pyrrolidine-3-carboxylic acids (4a-e) showed the highest anticonvulsant activity. Compound 4b was found to be the most potent one which exhibited 100% protection. Atlanta Publishing House LLC 2010-06-15 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/47 10.5155/eurjchem.1.2.102-109.47 European Journal of Chemistry; Vol. 1 No. 2 (2010): June 2010; 102-109 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/47/PDF

oai:ojs.www.eurjchem.com:article/49 2011-04-06T05:14:15Z eurjchem:ART driver

Optical and gas sensing studies of transparent ZnO thin film deposited from a new precursor by ultrasonic aerosol assisted chemical vapor deposition Hussain, Muzammil Hussain, Syed Tajammul New Precursor ZnO Thin Films CVD Gas Sensors Ceramic Substrate Transparent semi-conducting ZnO thin films with low resistivity and high transmittance in the visible optical region were deposited by the decomposition of bis(2,4-pentanedionate)-bis(aminoethanol) zinc(II) under an atmosphere of oxygen on ceramic, metal and quartz substrates by ultrasonic aerosol assisted chemical vapor deposition. The precursor was synthesized from bis(2,4-pentanedionate) zinc(II) and aminoethanol by sonication in acetonitrile and was characterized by melting point, infrared spectroscopy, CHNS-O elemental, atomic absorption, and single crystal X-ray diffraction analysis. TGA-FTIR was used to identify the cause of the weight losses and evolved gases formed during the breakup of the molecules. Electrical and optical measurements showed that the ZnO film has a band gap of 3.02 eV and typical semiconductor properties with a resistivity that depends on the thickness of the film. Powder XRD, SEM and EDX show that films are uniform, smooth and crystalline in nature, giving particle sizes in the range of 30-60 nm and exhibit a (002) orientation with the c-axis perpendicular to the substrate surface. Atlanta Publishing House LLC 2010-06-15 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/49 10.5155/eurjchem.1.2.96-101.49 European Journal of Chemistry; Vol. 1 No. 2 (2010): June 2010; 96-101 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/49/PDF

oai:ojs.www.eurjchem.com:article/52 2011-04-06T05:18:26Z eurjchem:ART driver

Inhibitive action of Bridelia retusa leaves extract on corrosion of mild steel in acidic media Patel, Niketan Rawat, Anamika Jauhari, Smita Mehta, Girish Bridelia retusa Acid corrosion inhibitor Electrochemical polarization Electrochemical impedance spectroscopy Scanning electron microscopy Mild steel Extract of Bridelia retusa leaves was investigated as corrosion inhibitor of mild steel in 1 N H2SO4 using conventional weight loss, electrochemical polarizations, electrochemical impedance spectroscopy and scanning electron microscopic studies. The weight loss results showed that the extract of Bridelia retusa leaves is excellent corrosion inhibitor and electrochemical polarizations data revealed the mixed mode of inhibition. While the results of electrochemical impedance spectroscopy have shown that the change in the impedance parameters, charge transfer resistance and double layer capacitance, with the change in concentration of the extract is due to the adsorption of active molecules leading to the formation of a protective layer on the surface of mild steel. Scanning electron microscopic studies provided the confirmatory evidence of improved surface condition, due to the adsorption, for the corrosion protection. Atlanta Publishing House LLC 2010-06-15 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/52 10.5155/eurjchem.1.2.129-133.52 European Journal of Chemistry; Vol. 1 No. 2 (2010): June 2010; 129-133 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/52/PDF

oai:ojs.www.eurjchem.com:article/53 2011-04-05T16:01:13Z eurjchem:ART driver

Flotation-separation of toxic metal ions from aqueous solutions using thiosemicarbazide derivatives as chelating agents and oleic acid as a surfactant Ghazy, Shaban El-Sayed Abu El-Reash, Gaber Mohamed Al-Gammal, Ola Ahmed Yousef, Tarek Mohamed Mercury Manganese Cadmium Thiosemicabazide derivatives Oleic acid Natural water A simple and rapid procedure was developed for flotation-separation of toxic metal ions namely Hg2+, Mn2+ and Cd2+ from aqueous solutions. Thiosemicarbazide derivatives such as: 1-(amino-N-phenylmethanethio)-4-(pyridine-2-yl)thiosemicarbazide (H2PPS), N-phenyl-2-(pyridine-2-ylcarbamothioyl)hydrazinecarboxamide (H2PBO), 1-(amino(thioformyl)-N-phenylform)-4-(pyridine-2-yl)thiosemicarbazide (H2APO), and 1-(amino-N-(pyridine-3-yl) methanethio)-4-(pyridine-2-yl)thiosemicarbazide (H2PPY) have been used as organic chelating agents and oleic acid (HOL) as a surfactant. The different parameters affecting the flotation process namely, metal ion, ligands and surfactant concentrations, foreign ions (which are normally present in fresh and saline waters), pH and temperature are examined. About 100% of mercury, cadmium and manganese ions float at room temperature (~ 25 oC), at a metal:ligand ratio of 1:2  and at pH ~5. The procedure was successfully applied to recover Hg2+, Mn2+ and Cd2+ ions spiked into some water samples. The flotation mechanism is suggested based on some physical and chemical studies on the ligands and metal-complexes isolated from the floated layers. Atlanta Publishing House LLC 2010-06-15 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/53 10.5155/eurjchem.1.2.76-82.53 European Journal of Chemistry; Vol. 1 No. 2 (2010): June 2010; 76-82 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/53/PDF

oai:ojs.www.eurjchem.com:article/54 2011-04-06T05:33:08Z eurjchem:REW driver

1,2,4-Triazine Chemistry Part I: Orientation of cyclization reactions of functionalized 1,2,4-triazine derivatives Abdel-Rahman, Reda Mohammady Makki, Mohammed Saleh Tawfik Ali, Tarik El-Sayed Ibrahim, Magdy Ahmed 1 2 4-Triazines Chemical reactivity Cyclization reactions Orientation of heterocyclization reactions of functionalized 1,2,4-triazines were studied by effect of substituents in 1,2,4-triazine moieties, type of the solvent used in the reaction and the temperature effect. Also, it was found that cyclization process depended mainly on the chemoselective and regioselectivity states of the parent substrate as well as preferring cite of ring closure. Atlanta Publishing House LLC 2010-09-29 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/54 10.5155/eurjchem.1.3.236-245.54 European Journal of Chemistry; Vol. 1 No. 3 (2010): September 2010; 236-245 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/54/PDF

oai:ojs.www.eurjchem.com:article/55 2011-12-31T08:09:40Z eurjchem:ART driver

Synthesis and biological activity of functionalized phosphorus derivatives of isatin imines El-Sawi, Emtithal Ahmed Mostafa, Tahia Bayoumy Radwan, Hyam Ali Mass spectroscopy Phosphorylation Triphenylphosphine Schiff bases X-ray crystallography Antimicrobial activity Isatin-3-imine derivatives (1a-d) have been synthesized. These compounds were then converted into phosphorylated products 2a, 2c with triethylphosphite and 3a-d with triphenylphosphine. The structures of the new compounds were confirmed by elemental analyses, IR, UV/VIS, 1H NMR, 13C NMR and MS studies. The structure of compound 1a was also confirmed by single crystal X-ray diffraction studies. Compounds 1b-d and 3c-d exhibited potent antibacterial activity against Bacillus subtilis and Escherichia Coli. Compound 3a was found to exhibit antifungal activity against the tested organisms. Atlanta Publishing House LLC 2011-12-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf chemical/x-cif https://www.eurjchem.com/index.php/eurjchem/article/view/55 10.5155/eurjchem.2.4.539-543.55 European Journal of Chemistry; Vol. 2 No. 4 (2011): December 2011; 539-543 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/55/PDF https://www.eurjchem.com/index.php/eurjchem/article/view/55/2538

oai:ojs.www.eurjchem.com:article/56 2011-04-06T05:17:24Z eurjchem:ART driver

Antimicrobial investigations on synthetic p-tolylazo derivatives of thienopyrimidinone based on an ortho funtionalized thiophene nucleus Gaber, Hatem M. Bagley, Mark C. Sherif, Sherif M. Thienopyrimidinone Aminoformylation Acetylation Hydrazinolysis Antimicrobial activity New derivatives of thieno[2,3-d]pyrimidin-4-one, 4a-c, and 6 were respectively synthezised based on thiophene derivative, 2c,ortho-disposed amino and ester groups. Carbohydrazide, bearing 7, was obtained by hydrazinolysis of 3-ethoxycabonylmethyl derivative, 4c. Compounds 4b and 7 were used to build up two series of novel 3-substituted-methylthieno[2,3-d]pyrimidin-4-ones, 7-11, and their corresponding 3-substituted-amino analogues 12, 15a,b, 18, which were of significant interest for biological study. The new thieno[2,3-d]pyrimidin-4-one derivatives, with various groups in position 3, were screened for their preliminary antimicrobial activity against a representative panel of Gram-positive and Gram-negative bacteria as well as fungi strains. The compounds tested displayed different levels of antibacterial and antifungal effects, with the assays carried out on six pathogenic bacteria and six pathogenic fungi. Of these compounds, the 3-unsubstituted-thieno[2,3-d]pyrimidin-4(3H)-one, 4a, showed the lowest effect on pathogenic bacteria, while the corresponding 3-substituted analogues produced inhibitory effects against bacteria similar or superior to the reference drug Tetracycline. For those derivatives of thieno[2,3-d]pyrimidin-4-one in which the 3-position contains a methylene moiety, it has been observed that the antibacterial effect was in general found to be significantly higher than the corresponding analogues with a substituted-amino moiety in position 3. Despite promising in vitro antibacterial activity of the new thienopyrimidin-4-ones, only compounds 7, 10 and 11, among the compounds tested, exhibited some kind of antifungal activity. The detailed synthesis and biological screening data were reported. Atlanta Publishing House LLC 2010-06-15 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/56 10.5155/eurjchem.1.2.115-123.56 European Journal of Chemistry; Vol. 1 No. 2 (2010): June 2010; 115-123 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/56/PDF

oai:ojs.www.eurjchem.com:article/59 2011-04-06T05:40:49Z eurjchem:ART driver

Prediction of n-octanol-water partition coefficient for polychlorinated biphenyls from theoretical molecular descriptors Safdari, Majid Golmohammadi, Hassan Quantitative Structure-Property Relationship n-Octanol–water partition coefficient Artificial neural network Partial least squares Genetic algorithm A quantitative structure-property relationship (QSPR) study was performed to develop models that relate the structures of 133 polychlorinated biphenyls to their n-octanol-water partition coefficients (log Kow). Molecular descriptors were derived solely from 3D structures of the molecules. The genetic algorithm-partial least squares (GA-PLS) method was applied as a variable selection tool.  The partial least square (PLS) method was used to select the best descriptors and the selected descriptors were used as input neurons in neural network model. These descriptors are: Balabane index (J), XY Shadow (SXY), Kier shape index (order 3) (3к), Wiener index (W) and Maximum valency of C atom (VmaxC). The use of descriptors calculated only from molecular structure eliminates the need for experimental determination of properties for use in the correlation and allows for the estimation of log Kow for molecules not yet synthesized. The root mean square errors for ANN predicted partition coefficients of training, test and external validation sets were 0.063, 0.112 and 0.126, respectively, while these values are 0.230, 0.164 and 0.297 for the PLS model, respectively. Comparison between these values and other statistical parameters for these two models revealed the superiority of the ANN over the PLS model. Atlanta Publishing House LLC 2010-12-22 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/59 10.5155/eurjchem.1.4.266-275.59 European Journal of Chemistry; Vol. 1 No. 4 (2010): December 2010; 266-275 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/59/PDF

oai:ojs.www.eurjchem.com:article/61 2011-04-06T05:52:28Z eurjchem:ART driver

Synthetic utility of enaminoester moiety in heterocyclic synthesis Madkour, Hassan Mohamed Fawzy Afify, Ameen Abd El-Maksode Abdallaha, Abdelaal Alameddin Elsayed, Galal Abd Elmegeed Salem, Marwa Sayed Thienopyridine Thienopyrimidine Enaminoester Thieno[2,3-b]pyridine-2-carboxylate was utilized to construct a variety of new heterocyclic systems such as thienopyrimidinone, thienopyridine and pyridothienoxazinone derivatives. Treatment of pyridothienoxazinone derivative with some other nitrogen nucleophiles afforded 3-substituted-pyridothienopyramidinone derivatives. Secondary amines such as morpholine, piperidine and N-methylaniline reacted smoothly with the oxazinone derivative. When the oxazinone derivative was allowed to react with ethanol containing few drops of pyridine or formamide as a basic catalyst and heated to reflux, afforded thienopyridine ester. All the compounds were fully characterized by means of IR, MS, 1H NMR spectra and elemental analyses. Atlanta Publishing House LLC 2010-12-22 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/61 10.5155/eurjchem.1.4.352-359.61 European Journal of Chemistry; Vol. 1 No. 4 (2010): December 2010; 352-359 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/61/PDF

oai:ojs.www.eurjchem.com:article/62 2011-12-31T08:09:40Z eurjchem:ART driver

Phytochemical studies on Diplotaxis harra growing in Sinai Atta, Emad Mahrous Hashem, Ahmed Ismail Ahmed, Ahmed Morsy Elqosy, Salah Mohamed Jaspars, Marsyl El-Sharkaw, Eman Ramadan Cruciferae Diplotaxis harra Flavonoid Antimicrobial activity Antibacterial activity Ethanolic extract Five main flavonoid glycosides were isolated from the ethanolic extract of Diplotaxis harra (Cruciferae), and were identified as quercetin, isorhamnetin 3-rhamnoside, isorhamnetin 3-o-rutinoside, isorhamnetin 3-glucosyl-4`-rhamnoside and isorhamnetin 3-o-β-glucoside. These compounds were identified according to their Rf values, partial and complete acid hydrolysis, UV, 1H-NMR, 13C-NMR and 2D NMR (HSQC, HMBC) spectroscopy. The alcoholic extract of plant was evaluated against some bacterial strains which showed moderate antibacterial activity, while petroleum ether extract doesn't show any activity. Atlanta Publishing House LLC 2011-12-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/62 10.5155/eurjchem.2.4.535-538.62 European Journal of Chemistry; Vol. 2 No. 4 (2011): December 2011; 535-538 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/62/PDF

oai:ojs.www.eurjchem.com:article/65 2011-04-06T05:47:13Z eurjchem:ART driver

Synthesis of some pyridyl and cyclohexyl substituted 1,2,4 triazole, 1,3,4-thiadiazole and 1,3,4-oxadiazole derivatives Ebrahimi, Sattar 1 2 4-Triazole 3 4-Thiadiazole 4-Oxadiazole Thiosemicarbazide New 1,2,4-triazoles (4a-c), 1,3,4-thiadiazoles (5a-c) and 1,3,4-oxadiazoles (6a-c) containing isomeric pyridyl and cyclohexyl were synthesized by intramolecular cyclization of 1,4-disubstituted thiosemicarbazides (3a-c) in alkaline media, acid and neutral condition respectively. The chemical structures of newly synthesized compounds were established with help of FT-IR, 1H-NMR and mass spectral data. Atlanta Publishing House LLC 2010-12-22 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/65 10.5155/eurjchem.1.4.322-324.65 European Journal of Chemistry; Vol. 1 No. 4 (2010): December 2010; 322-324 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/65/PDF

oai:ojs.www.eurjchem.com:article/69 2011-04-06T05:29:19Z eurjchem:ART driver

Synthesis and microstructure studies of nano-sized cerium phosphates Hanna, Adly Abdella Mousa, Sahar Mohamed Elkomy, Gehan Mahmoud Sherief, Marwa Adel Cerium phosphate Synthesis X-ray diffraction IR DSC/TGA TEM Cerium phosphate, CePO4, nanoparticles with hexagonal or monoclinic phase was synthesized by the reaction between Ce(SO4)2.4H2O and two different phosphate sources, H3PO4 and Na2HPO4. The obtained gel was dried and calcined at different temperatures (200, 400, and 800 оC). The effects of the precursor materials and the calcination temperatures on the produced phases were studied. Both X-ray diffraction (XRD) and infrared spectroscopy (IR) were used to follow the changes in the phase structure for the produced samples. The thermal behaviour of the as prepared samples was studied by using differential scanning calorimetric (DSC) and thermogravimetric analysis (TGA). The morphology, crystallinity and particle size of the produced samples as prepared and calcinated were characterized by transmission electron microscope (TEM). The analysis of TEM results indicated that CePO4 was prepared in nano-sized particles. Atlanta Publishing House LLC 2010-09-29 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/69 10.5155/eurjchem.1.3.211-215.69 European Journal of Chemistry; Vol. 1 No. 3 (2010): September 2010; 211-215 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/69/PDF

oai:ojs.www.eurjchem.com:article/71 2011-04-06T05:18:46Z eurjchem:ART driver

Novel isoquinoline derivatives from isochromen-1,3-dione Mahmoud, Mahmoud Refaee El-Shahawi, Manal Mohamed El-Bordany, Eman Abd El-Fattah Abu El-Azm, Fatma Saber Mohamed Isochromene-1 3-dione Isoquinolines 2-Cyanoethanoic hydrazide Nitrogen nucleophiles A number of novel isoquinoline derivatives have been synthesized using the readily obtainable (E)-4-(3,4-dimethoxybenzylidene)-4H-isochromene-1,3-dione, 2, via the reaction with different nitrogen nucleophiles such as cyanoethanoic hydrazide, cyclohexylamine, 2-aminothiophenol and p-toluenesulfonohydrazide. Furthermore, the reactivity of 2 towards thiophenol, and ethylcyanoacetate has been investigated. Atlanta Publishing House LLC 2010-06-15 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/71 10.5155/eurjchem.1.2.134-139.71 European Journal of Chemistry; Vol. 1 No. 2 (2010): June 2010; 134-139 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/71/PDF

oai:ojs.www.eurjchem.com:article/72 2011-04-06T05:26:49Z eurjchem:ART driver

Computation of the dipole moment of some heteronuclear diatomic molecules in terms of the revised electronegativity scale of Allred and Rochow Chakraborty, Tanmoy Ghosh, Dulal Chandra Electronegativity Scale of Allred and Rochow Polarity of molecules Dipole Moment Bond component of dipole moment Recently we have calculated the electronegativity of 103 elements of the periodic table relying upon the basic approach of Allred and Rochow. We carefully allayed the dimensional mismatch seemingly prevalent in all previous calculations so that the computed electronegativity is in its proper force dimension. Since the electronegativity is neither a physical observable nor a quantum mechanically determinable quantity, there is no bench-mark to perform any validity test of any scale of electronegativity. The descriptors of the real world such as charge distribution, bond energies, bond polarities and the dipole moments, force constants, atomic polar tensor and internuclear distances can be conceived in terms of electronegativity. Since the scale of Allred and Rochow is extremely popular among the scales of electronegativity, we have performed a validity test of the newly modified scale by calculating the dipole moments of as many as 48 molecules of widely diverse nature using the electronegativity values computed by us. The comparative study of computed dipole moments vis-à-vis the available experimental dipole moments of the corresponding molecules reveals that the present scale of electronegativity can be used realistically in representing the physical descriptors like charge distribution and dipole moments of molecules. Atlanta Publishing House LLC 2010-09-29 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/72 10.5155/eurjchem.1.3.182-188.72 European Journal of Chemistry; Vol. 1 No. 3 (2010): September 2010; 182-188 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/72/PDF

oai:ojs.www.eurjchem.com:article/74 2011-04-06T05:17:04Z eurjchem:ART driver

The cytotoxic activity of Linum grandiflorum leaves Mohammed, Magdy Mostafa Desoky Chen, Ming Zhai, Lin Ibrahim, Nabaweya Ali Linum grandiflorum Desf. Linaceae Flavonoids glycosides Cyanogenic glycosides Lignans Cytotoxicity Murine Leukemia (EL4) The CHCl3 and MeOH fractions of the leaves of Linum grandiflorum, showed cytotoxic activity against EL4 (Murine Leukemia) cell line with IC50 = 60 and 250 mg/mL respectively. Bioassay guided fractionation and isolation (BGFI) of the MeOH fraction resulted in the isolation of two new cytotoxic compounds 1 [luteolin 7-O-α-D-(6```-E-feruloyl)glucopyranosyl (1→2)-β-D-glucopyranoside] and 6 [2-[(3`-isopropoxy-O-β-D-glucopyranosyl)oxy]-2-methylbutane nitrile] against EL4 with IC50 = 0.2 and 0.3 mM/mL respectively, together with 2 [luteolin 7-O-β-D-glucopyranoside], 3 [vicenin-1], 4 [vicenin-2], 5 [vicenin-3], 7 [linamarin], 8 [lotaustralin], 9 [neolinustatin], and  10 [butan-2-O-β-D-glucopyranoside] which showed cytotoxicity against EL4 with IC50 = 0.2, 0.9, 0.8, 0.9, 0.4, 0.4, 0.2, 0.4 mM/mL respectively. BGFI of the CHCl3 fraction revealed the isolation of three cytotoxic aryltetrahydronaphthalene-type lignans identified as 11 [podophyllotoxin], 12 [deoxypodophylotoxin] and 13 [5-methoxypodophyllotoxin] against EL4 with IC50 = 0.2, 0.09 and 0.2 mM/mL respectively. The isolated compounds were structurally elucidated using 1D, 2D NMR, HR-ESI-MS, and HR-MALDI-MS techniques. Atlanta Publishing House LLC 2010-06-15 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/74 10.5155/eurjchem.1.2.110-114.74 European Journal of Chemistry; Vol. 1 No. 2 (2010): June 2010; 110-114 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/74/PDF

oai:ojs.www.eurjchem.com:article/75 2011-04-06T05:18:05Z eurjchem:ART driver

Synthesis and characterization of new chromeno[2,3-b]pyridines via the Friedländer reactions of 8-allyl-2-amino-4-oxo-4H-chromene-3-carboxaldehyde Ibrahim, Magdy Ahmed Mohamed DBU Friedländer Chromeno[2 3-b]pyridine Heteroannulated chromone New series of chromeno[2,3-b]pyridines, 2-8, have been obtained from 1,8-diazabicyclo [5.4.0]undec-7-ene catalyzed Friedländer reaction of 8-allyl-2-aminochromone-3-carboxaldehyde (1) with some carbonyl compounds containing a reactive α-methyl or methylene group namely 2-acetylthiophene, 3-acetylpyridine, 4-chloroacetophenone, 4,6-diacetylresorcinol, acetylacetone, dibenzoyl methane and acetoacetanilide. Heteroannulated chromones, 13-16, were prepared from Friedländer reaction of 1 with some cyclic α-methylene ketones namely 2-phenyliminothiazolidin-4-one, pyrazoline-3,5-dione, 5,5-dimethylcyclohexane-1,3-dione and thiobarbituric acid. Structures of the newly synthesized compounds have been established from elemental analysis and spectroscopic data. Atlanta Publishing House LLC 2010-06-15 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/75 10.5155/eurjchem.1.2.124-128.75 European Journal of Chemistry; Vol. 1 No. 2 (2010): June 2010; 124-128 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/75/PDF

oai:ojs.www.eurjchem.com:article/76 2011-04-05T15:57:36Z eurjchem:ART driver

The supramolecular structures of oximes: an update and the crystal structure of 1,3-diphenyl-propan-2-one oxime Low, John Nicolson Santos, Luís M. N. B. F. Lima, Carlos F. R. A. C. Brandão, Paula Gomes, Lígia R. H-bonding Oximes 1 3-Diphenyl-propan-2-one oxime X-ray diffraction Crystal structure The crystal structure of 1,3-diphenyl-propan-2-one oxime, C15H15NO, is described. The compound crystallises in the monoclinic space group C2/c. Centrosymmetrically related molecules are linked to form R22 (6) dimers. An update, since 2003, of a systematic analysis of the hydrogen bonding patterns in oxime structures with and without competitive O-H...A type acceptors (an acceptor other than the nitrogen of the oxime) functional group is made, taking into account their moieties. The majority of these oximes form dimeric, R22 (6), structures but R33 (8) and R44 (12) were also found. C3 chains which were classically claimed as the usual oxime H-bond pattern were rarely observed. They are mostly found in aldoxime structures. Atlanta Publishing House LLC 2010-06-15 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/76 10.5155/eurjchem.1.2.61-66.76 European Journal of Chemistry; Vol. 1 No. 2 (2010): June 2010; 61-66 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/76/PDF https://www.eurjchem.com/index.php/eurjchem/article/view/76/2521

oai:ojs.www.eurjchem.com:article/85 2011-04-06T05:27:24Z eurjchem:ART driver

Flotation, speciation and determination of iron(III) using aluminon in water, real samples and wastes of power stations El-Asmy, Ahmed Fawzy Abdel-Hanied Yousef, Wafaa Mohammad Akl, Magda Ali Iron(III) Speciation Determination Flotation Aluminon has been investigated for the separation of iron(III) by flotation technique. This reagent formed a 1:1 stable complex in aqueous solution. An intense violet layer is formed after flotation using oleic acid (HOL). A highly selective and sensitive spectrophotometric procedure is proposed for the determination of Fe(III) after overcoming all interferences. Preliminary studies show the possibility of forming a complex with Fe(II) to an extremely low extent. Trials have been carried out to separate Fe(II) and Fe(III) using NH4SCN or NaF. To prevent the oxidation of Fe(II), NaBH4 is used.  The separation of Fe(III) and Fe(II) can be achieved using 0.6 mg L-1 NaBH4.  The flotation- determination method was carried out at pH 2-3. The formation constant is 1.3×107 L mol-1 with molar absorptivity of 0.2×105 L mol-1 cm-1 and detection limit of 5×10-6 mol L-1. The effect of foreign ions is avoided using excess aluminon and 0.5 mg L-1 NaBH4. The proposed procedure was applied to synthetic mixtures [Fe(III) + Fe(II)], Fe(III) and some cations, wastes of power stations, simulated samples and real ores. Atlanta Publishing House LLC 2010-09-29 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/85 10.5155/eurjchem.1.3.189-194.85 European Journal of Chemistry; Vol. 1 No. 3 (2010): September 2010; 189-194 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/85/PDF

oai:ojs.www.eurjchem.com:article/86 2011-04-06T05:29:51Z eurjchem:ART driver

Simultaneous preconcentration of lead and cadmium ions with methyltrioctylammonium chloride supported on microcrystalline naphthalene and determination by flame atomic absorption spectrometry Behpour, Mohsen Soltani, Nasrin Ghoreishi, Sayed Mehdi Cadmium Lead FAAS Preconcentration Microcrystalline naphthalene A sensitive and selective preconcentration method has been developed for the determination of trace amounts of lead and cadmium ions by using naphthalene-methyltrioctylammonium chloride as an adsorbent. Lead and cadmium ions were retained by the adsorbent in the minicolumn as PbI42- and CdI42-, respectively. The column was washed by 5 mL of 2 mol L-1 nitric acid solution to elute the adsorbed cations. The collected eluents then were determined by flame atomic absorption spectrometry (FAAS). Potential factors affecting on the recovery of the analytes were investigated. Meanwhile optimum conditions were established. The preconcentration factor for lead (II) and cadmium (II) have been 300 and 100, respectively. The calibration curves were linear in the range of 3 to 100 ng mL-1 for Pb2+ and in the range of 1 to 100 ng mL-1 for Cd2+, in the original water samples. The detection limits for Pb2+ and Cd2+ are 0.42 and 0.072 ng mL-1 respectively. On the other hand, the relative standard deviation (RSD) for 11 replicate measurements of 20 ng mL-1 Pb2+ and Cd2+ were 2.2% and 1.4% in the initial solution respectively (n=11). The developed method was successfully applied for the determination of trace Pb2+ and Cd2+ ions in a variety of water samples. Atlanta Publishing House LLC 2010-09-29 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/86 10.5155/eurjchem.1.3.216-220.86 European Journal of Chemistry; Vol. 1 No. 3 (2010): September 2010; 216-220 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/86/PDF

oai:ojs.www.eurjchem.com:article/87 2011-04-06T06:10:24Z eurjchem:SC driver

Stability indicating HPTLC method for quantitative estimation of manidipine sihydrochloride API Karunanidhi, Santhana Lakshmi Sivasubramanian, Lakshmi Krishnan, Manikandan HPTLC Manidipine dihydrochloride Validation Stability studies Stress degradation studies Limit of detection A simple, selective, precise and stability indicating high performance thin layer chromatographic method has been established and validated for analysis of manidipine hydrochloride in bulk. The compound was analyzed on aluminium backed silica gel 60 F254 plates with methanol:water, 8.5:1.5 (v:v) as mobile phase. The system was found to give compact spots for manidipine dihydrochloride (RF=0.75). Densitometric analysis was performed at 230 nm. Regression analysis data for the calibration plot indicated good linear relationships between response and concentration over the range of 500-3000 ng/spot. The correlation coefficient, r2 was 0.998. The values of slope and intercept of the calibration plot were 2785.5 and 62.314, respectively. The method was validated for precision, recovery and robustness. The limits of detection and quantification were 20 and 50 ng, respectively. Manidipine dihydrochloride was subjected to acid, base, peroxide and sunlight induced degradation. In stability test the drug was susceptible to acid and base hydrolysis, oxidation and photodegradation. Statistical analysis proved that the method is repeatable, selective and accurate for manidipine. Because the method could effectively separate the drug from their degradation products, it can be used as a stability indicating method. Atlanta Publishing House LLC 2011-03-28 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/87 10.5155/eurjchem.2.1.113-116.87 European Journal of Chemistry; Vol. 2 No. 1 (2011): March 2011; 113-116 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/87/PDF

oai:ojs.www.eurjchem.com:article/90 2011-04-06T05:55:28Z eurjchem:SC driver

Zinc dust: An extremely active and reusable catalyst in acylation of phenols, thiophenol, amines and alcohols in a solvent-free system Pasha, Mohamed Afzal Reddy, Muthukur Bhojegowd Madhusudana Manjula, Krishnappa Zinc dust Phenols Thiophenol Amines Acyl chloride Solvent-Free condition A trace amount of zinc dust is able to promote instantaneous quantitative acylation of a large variety of functionalized phenols, thiophenol, amines and alcohols with acyl chlorides under solvent-free condition at 25 °C. The catalyst can be recovered and recycled making the procedure potentially useful for industrial applications. Atlanta Publishing House LLC 2010-12-23 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/90 10.5155/eurjchem.1.4.385-387.90 European Journal of Chemistry; Vol. 1 No. 4 (2010): December 2010; 385-387 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/90/PDF

oai:ojs.www.eurjchem.com:article/91 2011-04-06T05:27:52Z eurjchem:ART driver

Novel heterocyclic derivatives of pyrano[3,2-c]quinolinone from 3-(1-ethy1-4-hydroxy-2-oxo-2(1H)-quinolin-3-yl)-3-oxopropanoic acid Ibrahim, Magdy Ahmed Hassanin, Hany Mohamed Gabr, Yassin Abdel-Allah Alnamer, Youssef Abdel-Salam β-ketoacid Quinolinone Chromone Cyclocondensation Knoevenagel condensation 3-(1-Ethyl-4-hydroxy-2-oxo-2(1H)-quinolin-3-yl)-3-oxopropanoic acid (2) has been synthesized. The chemical behaviour of β-ketoacid 2 was studied towards condensation reactions with salicylaldelyde, 2-hydroxy-1-naphthaldehyde, 1-phenyl-4-hydroxy-2-oxo-quinoline-3-carboxaldehyde, 2-hydroxy-4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carboxalde-hyde, 2-amino-3-formylchromone and its 8-allyl analog, 3-cyanochromone and its 8-allyl analog. Structures of the newly synthesized products have been deduced from their elemental analysis and spectral data. Atlanta Publishing House LLC 2010-09-29 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/91 10.5155/eurjchem.1.3.195-199.91 European Journal of Chemistry; Vol. 1 No. 3 (2010): September 2010; 195-199 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/91/PDF

oai:ojs.www.eurjchem.com:article/94 2011-12-31T08:09:40Z eurjchem:ART driver

Derivation of Gordy’s scale and computation of some useful descriptors of chemical reactivity Islam, Nazmul Electronegativity Orbital exponent Mulliken electronegativity scale Gordy electronegativity scale Chemical reactivity descriptors Convergence of Gordy’s and Mulliken’s scale A new atomic electronegativity scale is proposed by using the essence of electronegativity definitions of Gordy and Mulliken. The new computed atomic electronegativity data is found to satisfy all the sine qua non of a reasonable scale of atomic electronegativity. The electronegativity data is used to compute some useful descriptors of chemical reactivity. Comparative studies reveal that the new approach to derive the Gordy’s scale of electronegativity is a successful venture. Atlanta Publishing House LLC 2011-12-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/94 10.5155/eurjchem.2.4.448-454.94 European Journal of Chemistry; Vol. 2 No. 4 (2011): December 2011; 448-454 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/94/PDF

oai:ojs.www.eurjchem.com:article/98 2011-04-06T05:49:21Z eurjchem:ART driver

Interaction of charge transfer fluorescence probe with non-ionic surfactants: Estimation of physico-chemical properties and association constant Singh, Takhellambam Sanjoy Mitra, Sivaprasad Fluorescence Non-ionic surfactants Intramolecular charge transfer CMC Micropolarity Association constant Fluorescence behavior of intramolecular charge transfer probe trans-ethyl-p-(dimethylamino) cinnamate (EDAC) is extremely sensitive to the local environment. This study explores the interaction of EDAC with several Igepal, Brij and Tween series of non-ionic surfactants by steady state and picoseconds time-resolved fluorescence spectroscopy. The physico-chemical properties, like critical micelle concentration and micropolarity of the micellar media surrounding the probe were determined. In most of the cases, the observed values were in good agreement with the data reported in the literature. Results obtained from time-resolved fluorescence experiments show a substantial reduction in total non-radiative decay rate of the probe in micellar medium compared to that in aqueous phase. This indicates preferential association of the probe inside the micellar core. The association constant of the probe-micelle interaction was also evaluated in different cases. Atlanta Publishing House LLC 2010-12-22 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/98 10.5155/eurjchem.1.4.341-347.98 European Journal of Chemistry; Vol. 1 No. 4 (2010): December 2010; 341-347 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/98/PDF

oai:ojs.www.eurjchem.com:article/101 2011-04-06T05:53:53Z eurjchem:SC driver

Stabilization of 5-aminolevulinic acid by the zinc(II) ion in an aqueous solution Sakiyama, Hiroshi Inoue, Hidetatsu Md.Kudrat-E-Zahan, Md.Kudrat-E-Zahan Hueki, Shoichi Tachiya, Naohisa Nishida, Yuzo 5-aminolevulinic acid Zinc(II) ion UV-VIS absorption spectra NMR pH It is known that 5-aminolevulinic acid (5-ALA) is not stable in an aqueous solution because of the auto-condensation reaction between two 5-ALA molecules; however, in this study, 5-ALA was stabilized by the zinc(II) ion in an aqueous solution of neutral pH. This stabilization effect was ascertained by UV-Vis Spectroscopy and 1H and 13C NMR Spectroscopy. Atlanta Publishing House LLC 2010-12-22 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/101 10.5155/eurjchem.1.4.373-376.101 European Journal of Chemistry; Vol. 1 No. 4 (2010): December 2010; 373-376 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/101/PDF

oai:ojs.www.eurjchem.com:article/103 2011-04-06T06:09:20Z eurjchem:ART driver

Platinum 1,10-phenanthroline: Photosensitizer for photocatalytic degradation of 4-chlorophenol Aboul-Gheit, Ahmed Kadry Ahmed, Sahar Moustafa El-Desouki, Doaa Samir Abdel-Azeem, Samira Mohamed El-Shahat, Mohamed Fathy Photosensitizer 1 10-phenanthroline 4-Chlorophenol Pt-complex Photodegradation 1O2 It is more economic to apply photodegradation of organic pollutants in presence of the visible light irradiation (sunlight) than applying more costfull ultraviolet lamps. Hence, platinum 1,10-phenanthroline complex has been prepared and tested as a photosensitizer for photodegrading 4-chlorophenol in water, which has been found almost completely achieved (98.5 %) after three hours of visible irradiation. Nevertheless, irradiation at 364 and 254 nm exhibits lower efficiencies. At visible irradiation, the platinum complex gives the highest activation of singlet state oxygen formation (1O2) compared to 364 and 254 nm irradiation as supported by electron para-magnetic resonance data. On the other hand, the behavior of formation and disappearance of photodegradation intermediates: hydroquinone, benzoquinone, hydroxybenzoquinone, using the platinum complex applying the three current irradiations are found to supports these findings. However, organic acids have accumulated as a function of irradiation time and hence considered to be rate-controlling. Atlanta Publishing House LLC 2011-03-28 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/103 10.5155/eurjchem.2.1.104-108.103 European Journal of Chemistry; Vol. 2 No. 1 (2011): March 2011; 104-108 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/103/PDF

oai:ojs.www.eurjchem.com:article/104 2011-04-06T05:53:29Z eurjchem:ART driver

Synthesis of some novel pyridine and naphthyridine derivatives Abdelrazek, Fathy Mohamed Kassab, Nazmi Abdel-Latif Metwally, Nadia Hanafy Sobhy, Nehal Ahmed Fur-2-ylethylidenemalononitrile Thien-2-ylethylidenemalononitrile Dihydro-pyridines Pyrazolo-naphthyridines Pyrimido-naphthyridines 2-[1-(Furan- or thiophen-2-yl)ethylidene)malononitriles (1a,b) undergo dimerization reactions in ethanol catalyzed by sodium ethoxide to afford 2-[4,6-di(furan- or thiophen-2-yl)-3-cyano-6-methyl-5,6-dihydropyridin-2(1H)-ylidene]malononitrile derivatives (2a,b), respectively. Compounds 2a and 2b couple with arene diazonium salts (3a-c) to afford the hydrazo derivatives (4a-f). They react also with hydrazines (5a,b) to afford the pyrazolo[3,4-H][1,6]naphthyridine derivatives (6a-d) and with urea derivatives (7a-c) to afford the pyrimido[4,5-H][1,6]naphthyridine derivatives (8a-f), respectively. Atlanta Publishing House LLC 2010-12-22 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/104 10.5155/eurjchem.1.4.368-372.104 European Journal of Chemistry; Vol. 1 No. 4 (2010): December 2010; 368-372 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/104/PDF

oai:ojs.www.eurjchem.com:article/105 2011-04-06T05:46:07Z eurjchem:ART driver

Thiazole derivatives as corrosion inhibitors for C-steel in sulphuric acid solution Fouda, Abd El-Aziz Al-Sarawy, Ahmed El-Katori, Emad Corrosion inhibitors C-steel Weight loss Synergistic effect Polarization Thiazole derivatives 5-phenylazo-2-thioxo-thiazolidin-4-one and four of its derivatives have been investigated as corrosion inhibitors for C-steel in 1 M sulphuric acid solution using weight-loss and galvanostatic polarization techniques. The efficiency of the inhibitors increases with increase in inhibitor concentration but decreases with a rise in temperature. The conjoint effect of the thiazole derivatives and KBr, KSCN and KI has also been studied. The apparent activation energy (Ea*) and other thermodynamic parameters (ΔS*, ΔH* and ΔG*ads) for the corrosion process have also been calculated. The galvanostatic polarization data indicated that, the inhibitors were of mixed-type, but the cathode is more polarized than the anode. The slopes of the cathodic and anodic Tafel lines (ßc and ßa) are approximately constant and independent of the inhibitor concentration. The adsorption of these compounds on C-steel surface has been found to obey the Temkin's adsorption isotherm. The mechanism of inhibition was discussed in the light of the chemical structure of the undertaken inhibitors. Atlanta Publishing House LLC 2010-12-22 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/105 10.5155/eurjchem.1.4.312-318.105 European Journal of Chemistry; Vol. 1 No. 4 (2010): December 2010; 312-318 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/105/PDF

oai:ojs.www.eurjchem.com:article/108 2011-04-06T05:42:32Z eurjchem:ART driver

Synthesis of octahydroquinazolinone derivatives using silica sulfuric acid as an efficient catalyst Mobinikhaledi, Akbar Foroughifar, Naser Khodaei, Homila Quinazolinone Silica sulfuric acid Dimedone Biginelli reaction Octahydroquinazolinone derivatives were synthesized in moderate to high yields via one-pot three component Biginelli reaction of dimedone, urea or thiourea and corresponding aromatic aldehydes in the presence of silica sulfuric acid as an efficient catalyst, in ethanol under reflux conditions. This protocol offers several advantages including good yields of products and easy experimental work-up procedure. Atlanta Publishing House LLC 2010-12-22 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/108 10.5155/eurjchem.1.4.291-293.108 European Journal of Chemistry; Vol. 1 No. 4 (2010): December 2010; 291-293 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/108/PDF

oai:ojs.www.eurjchem.com:article/110 2011-04-06T05:51:58Z eurjchem:ART driver

Derivative spectrophotometric method for simultaneous determination of ezetimibe and simvastatin in combined tablets Moussa, Bahia Abbas Mohamed, Marwa Fadel Youssef, Nadia Fayek Ezetimibe Simvastatin First derivative spectrophotometry Simultaneous determination Degradation products Drug products The introduced study portrays the development and validation of an effortless, speedy and selective first order derivative zero-crossing spectrophotometric method to estimate ezetimibe and simvastatin simultaneously in combined drug products over and above in the presence of ezetimibe alkaline degradation products. Ezetimibe and its alkaline degradates spectra showed zero-crossing point at 249 nm, so the amplitude at 249 nm could be used for calculating the concentration of simvastatin. While simvastatin and ezetimibe alkaline degradates spectra showed a zero-reading value at 261 nm, so ezetimibe could be determined by measuring the amplitude at 261 nm. Regression plots revealed good linear relationships in the concentration range 1-16 µg/mL with accuracy checked by conducting recovery studies; average recovery was 99.61 ± 1.183 and 100.47 ± 1.310 for ezetimibe and simvastatin, respectively. The suggested first derivative spectrophotometric method was successfully applied for the determination of the cited drugs in "Inegy 10/10, 10/20 and 10/40 tablets". Satisfactory results were obtained for the recovery of both drugs and were in good agreement with the labeled amounts.  Method validation was estimated according to USP guidelines. Atlanta Publishing House LLC 2010-12-22 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/110 10.5155/eurjchem.1.4.348-351.110 European Journal of Chemistry; Vol. 1 No. 4 (2010): December 2010; 348-351 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/110/PDF

oai:ojs.www.eurjchem.com:article/112 2011-04-06T05:32:44Z eurjchem:SC driver

DABCO as an efficient catalyst for the synthesis of 3-cyano-2(1H)-pyridinones and their 2-imino analogues Beheshtia, Yahia Shirazi Khorshidi, Maliheh Heravi, Majid Momahed Baghernejad, Bita 1 4-Diaza-bicyclo[2 2 2]octane Cyano-2(1H)-pyridinones Cyano-2(1H)-iminopyridines 3 4-Dimethoxyacetophenone DABCO Catalyst 3-cyano-2(1H)-pyridinones and their 2-imino analogues have been synthesized in good yields via a one-pot multi-component reaction of 3,4-dimethoxyacetophenone, malononitrile or ethylcyanoacetate, ammonium acetate and various aldehydes in the presence of  1,4-diaza-bicyclo[2,2,2]octane (DABCO) in ethanol. DABCO has been widely used as a catalyst for the organic reactions and we selected it as an efficient catalyst to synthesis of 3-cyano-pyridines. All products were characterized by melting point, IR, 1H NMR and GC/MS studies. Atlanta Publishing House LLC 2010-09-29 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/112 10.5155/eurjchem.1.3.232-235.112 European Journal of Chemistry; Vol. 1 No. 3 (2010): September 2010; 232-235 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/112/PDF

oai:ojs.www.eurjchem.com:article/113 2011-04-06T05:41:43Z eurjchem:ART driver

Synthesis, spectroscopic and thermal characterization of quinoxaline metal complexes Badawy, Mohamed Ahmed Mohamed, Gehad Genidy Omar, Mohamed Mohamed Nassar, Mamdouh Mohammed Kamel, Ahmed Badr Quinoxaline Transition metal complexes Spectroscopy Thermal analyses DTA/TG Biological activity The coordination behaviour of the quinoxaline ligand with N and O donation sites, derived from 3-(2-oxo-2-p-tolylethyl)quinoxalin-2(1H)-one (HL), towards some transition metal ions namely Mn(II), Fe(III), Co(II), Ni(II), Cu(II) and Zn(II) are reported. The metal complexes are characterized based on elemental analyses, IR, 1H NMR, solid reflectance, magnetic moment, molar conductance and thermal analyses (TG, DTG and DTA). The ionization constants of the quinoxaline ligand as well as the stability constants of its metal chelates are calculated spectrophotometrically at 25 oC and ionic strength = 0.1 M (1M NaCl). The chelates are found to have octahedral structure. The ligand and its chelates are subjected to thermal analyses and the different activation thermodynamic parameters are calculated from their corresponding DTG curves to throw more light on the nature of changes accompanying the thermal decomposition process of these compounds. The biological activity of the synthesized ligand and its metal complexes also are screened against the desert locust Schistocerca gregaria (Forsk) (Orthoptera-Acrididae) and its adult longevities. They showed remarkable biological activity. Atlanta Publishing House LLC 2010-12-22 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/113 10.5155/eurjchem.1.4.282-288.113 European Journal of Chemistry; Vol. 1 No. 4 (2010): December 2010; 282-288 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/113/PDF

oai:ojs.www.eurjchem.com:article/116 2011-04-06T05:40:25Z eurjchem:ART driver

Determination of voglibose in pharmaceutical formulations by high performance liquid chromatography using refractive index detection Lakshmi, Karunanidhi Rajesh, Tirumala Voglibose HPLC RID Validation Pharmaceutical formulations Voglibose is a potent glucosidase inhibitor used for type II diabetes mellitus. A simple and rapid high performance liquid chromatographic method with refractive index detection was developed for the determination of voglibose in pharmaceutical formulations. Development was performed on a C18 (250 x 4.6 mm, 5 µ) column using a mobile phase mixture of acetonitrile and water in the ratio of 50:50 which was fixed at a flow rate of 0.5 mL/min. Polarity of voglibose was found to be positive and elution time was found to be less than 5 min. The method was also validated as per ICH guidelines for its linearity, precision, accuracy and robustness. The limit of detection and quantification (LOD and LOQ) were found to be 2.91 and 9.7 µg/mL. The method could be successfully applied for the quantification of voglibose in pharmaceutical formulations. Atlanta Publishing House LLC 2010-12-22 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/116 10.5155/eurjchem.1.4.262-265.116 European Journal of Chemistry; Vol. 1 No. 4 (2010): December 2010; 262-265 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/116/PDF

oai:ojs.www.eurjchem.com:article/119 2011-04-06T05:20:30Z eurjchem:REW driver

Theory and computations of two-photon absorbing photochromic chromophores Masunov, Artem E. Mikhailov, Ivan A. TDDFT Organic photochemistry Photocyclization Photoinduced reactions Two-photon absorption State-to-state transition dipoles Exponential growth in information technology generates ever increasing amounts of data, making recording density of the storage media crucially important. Two-photon absorption was proposed as a basis for high-density multi-layer technology for optical memory and logic devices. This technology suggests to use polymers, doped with photochromic compounds that undergo a reversible photoinduced isomerization, or photoswitching. In this review we consider recent theoretical works and benchmarking studies of the DFT-based methods, capable to predict two-photon absorption (2PA) and photochemical activity, Next we review the applications of these methods to design a prototype molecule that combines the photon-mode recording property of photochromic compounds with large 2PA cross-section. We conclude that a posteriori Tamm-Dancoff approximation to the second order CEO approach in Density Functional Theory is the powerful tool for both quantitative predictions and qualitative understanding of the excited state processes in photophysics and photochemistry. We also emphasize general principles for the rational design of a two-photon operated photoswitch. Atlanta Publishing House LLC 2010-06-15 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/119 10.5155/eurjchem.1.2.142-161.119 European Journal of Chemistry; Vol. 1 No. 2 (2010): June 2010; 142-161 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/119/PDF

oai:ojs.www.eurjchem.com:article/120 2011-04-06T05:28:20Z eurjchem:ART driver

Synthesis, characterization and antibacterial activity of nickel (II) and copper (II) complexes of N-(alkyl(aryl)carbamothioyl)-4-nitrobenzamide Saeed, Sohail Rashid, Naghmana Ali, Muhammad Hussain, Rizwan Thiourea derivatives Transition metal complexes X-ray structure determination Phase-transfer catalyst Antibacterial activity Nickel and copper metal complexes of N-(R-carbamothioyl)-4-nitrobenzamide (R = diphenyl and ethylbutyl) were synthesized and characterized by IR, 1H NMR, mass spectrometry and elemental analysis. The spectroscopic data are consistent with the ligand and the metal complexes containing two O and S chelated ligands. N-(diphenylcarbamothioyl)-4-nitrobenzamide, HL1, was characterized by a single crystal X-ray diffraction study. It crystallizes in the triclinic space group P  with unit cell dimensions of a = 6.8044(4) Å, b = 10.0113(6) Å, c = 13.2365(8) Å, α = 6.8044(4) °, β = 78.171(4) °, γ = 13.2365(8)°, V = 882.43(9) Å3. The ligands coordinate as bidentates yielding essentially neutral complexes of the type [ML2]. The ligands and complexes were screened for their in vitro antibacterial activities and comparatively the complexes showed greater antibacterial efficacy than the thiourea derivative ligands. Atlanta Publishing House LLC 2010-09-29 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/120 10.5155/eurjchem.1.3.200-205.120 European Journal of Chemistry; Vol. 1 No. 3 (2010): September 2010; 200-205 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/120/PDF

oai:ojs.www.eurjchem.com:article/121 2011-04-06T05:54:59Z eurjchem:SC driver

Analytic perturbation theory to study the effect of screening on alignment of atomic inner shell vacancies Sharma, Ajay Mittal, Raj Perturbation theory Screening effect Vacancy alignment Non-relativistic dipole approximation L sub-shells An analytic perturbation theory has been developed for screened Coulomb radial wave functions by interpolating the screened Coulomb potential of McEnnan for elements lanthanum to uranium and was used to calculate alignment of vacancies in L3 sub shell. To check the authenticity of the present method of calculation, the intermediate steps are compared with our earlier formulation of point Coulomb potential for the calculations. A close agreement has been obtained among the values of intermediate steps involved in both the formulations that proved the reliability of present calculations and prompted us to extend the calculations for the elements lanthanum to uranium in the energy region threshold to 60 keV. Atlanta Publishing House LLC 2010-12-22 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/121 10.5155/eurjchem.1.4.381-384.121 European Journal of Chemistry; Vol. 1 No. 4 (2010): December 2010; 381-384 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/121/PDF

oai:ojs.www.eurjchem.com:article/124 2011-04-06T05:31:08Z eurjchem:ART driver

Synthesis, spectroscopic characterization, crystal structure and pharmacological properties of some novel thiophene-thiourea core derivatives Saeed, Sohail Rashid, Naghmana Ali, Muhammad Hussain, Rizwan Jones, Peter G. Thiourea derivatives Thiophene Single crystal structure determination Mass fragmentation Antifungal activity This article presents our research concerning the synthesis of new thiophene-thiourea derivatives (1-12) and their pharmacological properties. These novel thiophene-thiourea derivatives were synthesized and characterized by IR, 1H and 13C NMR spectroscopy, mass spectrometry and elemental analysis. The crystal structure of N,N-diphenyl-N'-(thiophene-2-carbonyl)-thiourea was determined from single crystal X-ray diffraction data. It crystallizes in the monoclinic space group P21 with unit cell dimensions of a=11.7469(5) Å, b=6.0849(2) Å, c=12.5792(6) Å, β= 117.736(7) ° and V = 795.8(6) Å3. The mass fragmentation pattern has also been discussed. The synthesized compounds were screened for their in vitro antifungal activities against the standard strains: C. Albicans, C. Glabrata, and C. Tropicalis. The compounds N-thiophene-N',N'-bis(dimethyl-phosphinoylmethyl)thiourea, N-[(4-nitro-1H-imidazol-2-yl)carbamothioyl]thiophene-2-carboxamide and N,N-diethyl-N'-(thiophene-2-carbonyl)-thiourea showed significant antifungal activities against microbial species. Atlanta Publishing House LLC 2010-09-29 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/124 10.5155/eurjchem.1.3.221-227.124 European Journal of Chemistry; Vol. 1 No. 3 (2010): September 2010; 221-227 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/124/PDF

oai:ojs.www.eurjchem.com:article/125 2011-04-06T06:03:18Z eurjchem:ART driver

Synthesis, configuration and properties of some new 3,4,5-substituted oxazolidin-2-ones Mavrova, Anelia Tsenova Denkova, Pavletta Stoyanova Tsenov, Jordan Andreev Oxazolidin-2-ones Stereochemistry Configuration Mannich reaction Analgesis activity Drug similarity Novel 3,4,5-substituted-oxazolidin-2-ones containing piperazine, 1-(4-chlorophenyl) piperazine, benzhydrylpiperazine, morpholine and piperidine rings were synthesized via Mannich reaction. The stereochemistry of syn and anti-isomers was assigned using the observed differences in the chemical shifts of the oxazolidinone ring protons and the values of vicinal coupling constants (3J) between the two protons of the oxazolidin-2-one ring. For all compounds NOE (Nuclear Overhauser Effect) NMR spectra were measured in order to prove additionally the position of the substituents in the oxazolidin-2-one ring. Some physic chemical, steric and electronic properties of the compounds were determined in order to establish the similarity between the synthesized and reference compounds. The performed computations showed that the anti-isomers possessed lower electronic energies in comparison to these of syn-compounds. The nucleus-nucleus repulse energies (NRE) and the highest occupied molecular orbital energies (HOMO) of the anti-isomers are higher than the HOMO and NRE energies of syn-compounds. The Connolly Solvent Accessible Surface Area (SAS) and Connolly Molecular Surface Area (MS) values of anti-isomers are lower than these of syn-isomers. The same relations were observed for the reference compounds. Probably the differences in the electronic and steric properties are responsible not only for the higher LD50 value of the reference anti-compound, but also may contribute to the higher toxicity of the prepared anti-Mannich bases in comparison to that of the syn-diastereoisomers. Atlanta Publishing House LLC 2011-03-28 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/125 10.5155/eurjchem.2.1.18-24.125 European Journal of Chemistry; Vol. 2 No. 1 (2011): March 2011; 18-24 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/125/PDF

oai:ojs.www.eurjchem.com:article/126 2011-09-30T03:44:50Z eurjchem:ART driver

Synthesis and optimization of methyl 5-acetyl-1,4-dihydro-2,6-dimethyl-4-(substituent benzylidene)pyridine-3-carboxylate Liu, Rui Dong Zhang, Jian Unsymmetrical 1 4-dihydro-Hantzsch pyridine Condensation Catalyst Cyclization Polar aprotic solvent Two 1,4-dihydro-Hantzsch pyridine derivatives were synthesized by three steps. In the condensation step, the reaction time can be shortened to 1.5 h through using H2SO4-acetic anhydride system as a catalyst rather than the acetic acid-piperidine systemin the cyclization step, the reaction time was shortened from 20 h in ethanol to 15 h in polar aprotic solvent, and the yield of two products also was increased from 43.3% and 39.7% in traditional solvent to 93.2% and 90.1% in polar aprotic solvent. Atlanta Publishing House LLC 2011-09-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/126 10.5155/eurjchem.2.3.308-310.126 European Journal of Chemistry; Vol. 2 No. 3 (2011): September 2011; 308-310 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/126/PDF

oai:ojs.www.eurjchem.com:article/128 2011-04-06T05:28:52Z eurjchem:ART driver

Extraction of natural color component from the bark of Belleric myrobalan (Terminalia bellerica): Kinetic and adsorption studies Vinod, Konaghatta Narayanachar Puttaswamy, Puttaswamy Gowda, Kurikempanadoddi Ninge Sudhakar, Rajagopal Baicalein Terminalia bellerica Identification Adsorption-kinetics Thermodynamics Baicalein, a trihydroxy flavone from the bark of Terminalia bellerica was identified as a natural colorant. The potential of the natural color component on silk yarn was tested. Its properties of color fastness with regard to light, washing and crocking were investigated and found to be satisfactory. Thermodynamic parameters were evaluated. The positive value of enthalpy of dyeing suggests the endothermic nature of dyeing and the negative entropy implies that the dye molecules are orderly arranged on silk. The positive value of free energy confirms the affinity between the dye molecules and the protein content of silk. Further, adsorption studies were carried out to determine the best fit isotherm model for the present dyeing system. The Langmuir isotherm model fitted the experimental data very well with a relatively high regression coefficient compared to the Freundlich and Tempkin-Pyzhev isotherm models. In conclusion, the Terminalia bellerica bark can be used as a potential source of natural dye for silk. Atlanta Publishing House LLC 2010-09-29 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/128 10.5155/eurjchem.1.3.206-210.128 European Journal of Chemistry; Vol. 1 No. 3 (2010): September 2010; 206-210 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/128/PDF

oai:ojs.www.eurjchem.com:article/131 2011-04-06T05:43:19Z eurjchem:ART driver

One new cucurbitane triterpenoid from the fruits of Momordica charantia Liu, Jie-Qing Chen, Jian-Chao Wang, Cui-Fang Qiu, Ming-Hua Momordica charantia Cucurbitane triterpenoids Neokuguaglucoside Semi-empirical quantum chemistry methods AM1 One new cucurbitane triterpenoid commonly named neokuguaglucoside, together with three known compounds momordicoside M, momordicoside N, and momordicoside A were isolated from the fresh fruits of Momordica charantia. The new one's structure with an interesting sugar-like groups attached to the side chain was elucidated by spectroscopic analysis and semiepirical (AM1) quantum chemical method. Atlanta Publishing House LLC 2010-12-22 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/131 10.5155/eurjchem.1.4.294-296.131 European Journal of Chemistry; Vol. 1 No. 4 (2010): December 2010; 294-296 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/131/PDF

oai:ojs.www.eurjchem.com:article/134 2011-04-06T06:02:06Z eurjchem:ART driver

Study on the annealing-dependent photoluminescence properties of SnO2 cluster-system structures Zhu, Yunqing Chen, Yiqing Zhang, Xinhua SnO2 cluster-system Thermal evaporation Photoluminescence Oxygen vacancy Bound H2O molecule Energy minimization computation SnO2 cluster-system structures were synthesized via a two-step temperature-rising thermal evaporation method with short oxidation time. Field emission scanning electron microscopy, X-ray diffraction and transmission electron microscopy were used to characterize the morphological and structural feature of the product as nanowire cluster and nanoparticle cluster. The photoluminescence spectra exhibit that, as annealing time in air increases, the intensity of the newly found strong ultra-violet emission decreases while the green emission is increased. Raman spectrum and X-ray photoelectron spectroscopy investigations reveal that the relatively decreasing intensity was dominated by the increasing oxygen vacancy. Further calculation based on the SnO2 crystal lattices with H2O molecules at different steps in evaporation process was performed. The result of this calculation confirms that, rather than the influence of H2O molecules from air, the decreasing intensity is the result of the combined action of the formation of oxygen vacancy and the energetic oxygen compensation in annealing treatment. Atlanta Publishing House LLC 2011-03-28 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/134 10.5155/eurjchem.2.1.8-13.134 European Journal of Chemistry; Vol. 2 No. 1 (2011): March 2011; 8-13 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/134/PDF

oai:ojs.www.eurjchem.com:article/147 2011-04-06T06:10:00Z eurjchem:ART driver

Voltammetric and viscometric studies of flavonoids interactions with DNA at physiological conditions Hussain, Syed Tajammul Siddiqa, Asima DNA Flavonoids Cyclic voltammetry Binding constant Gibbs free energy Binding site size Cyclic voltammetric behaviour of three flavonoids: quercetin, morin and rutin was investigated for their interaction with DNA at pH = 4.7 and pH = 7.4 at body temperature (310 K), using glassy carbon electrode. The diffusion coefficients of the free and DNA bound forms of the flavonoids were evaluated using Randles–Sevcik equation. The binding parameters like binding constant, binding site size and binding free energy were also determined from voltammetric data. Moreover, the binding modes of flavonoids with DNA were evaluated from viscommetric analysis. A comparatively high value of binding constant, binding site size and diffusion coefficients for quercetin reveals its stronger binding with DNA under physiological conditions. The negative values of ∆G indicate the spontaneity of binding of flavonoids with DNA. Atlanta Publishing House LLC 2011-03-28 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/147 10.5155/eurjchem.2.1.109-112.147 European Journal of Chemistry; Vol. 2 No. 1 (2011): March 2011; 109-112 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/147/PDF

oai:ojs.www.eurjchem.com:article/150 2011-04-06T05:41:14Z eurjchem:ART driver

On shapes, molecules and models: An insight into chemical methodology Pagliaro, Mario Chemical methodology Chemical education Reductionism Quantum chemistry Models in chemistry Insight into chemistry conceptual foundations shows that a powerful, autonomous chemical methodology exists which is based on visualization and association of chemical "building blocks". Such methodology has been expanded by the use of incommensurable theories resulting from the interplay of quantum mechanics and heuristic chemical concepts, resulting in models of great utility as predictive tools in guiding the creation of new and useful substances. Understanding such historical development has real benefits to chemistry practitioners, be they researchers, analysts or chemical educators. Atlanta Publishing House LLC 2010-12-22 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/150 10.5155/eurjchem.1.4.276-281.150 European Journal of Chemistry; Vol. 1 No. 4 (2010): December 2010; 276-281 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/150/PDF

oai:ojs.www.eurjchem.com:article/154 2011-04-06T05:55:51Z eurjchem:REW driver

1,2,4-Triazine Chemistry Part II: Synthetic approaches for phosphorus containing 1,2,4-triazine derivatives Abdel-Rahman, Reda Mohammady Ibrahim, Magdy Ahmed Ali, Tarik El-Sayed 1 2 4-Triazine Phosphorus Phosphorylation Cyclization Heterocyclization This review represents the methods developed for the synthesis of phosphorus containing 1,2,4-triazine moieties. These methods depends on the phosphorylation of side functional groups of 1,2,4-triazines and cyclization of side functional groups of 1,2,4-triazines with phosphorus reagents to give isolated and fused phosphorus heterocyclic systems. Atlanta Publishing House LLC 2010-12-22 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/154 10.5155/eurjchem.1.4.388-396.154 European Journal of Chemistry; Vol. 1 No. 4 (2010): December 2010; 388-396 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/154/PDF

oai:ojs.www.eurjchem.com:article/155 2011-04-06T05:45:44Z eurjchem:ART driver

Thermodynamic investigation of a new water-soluble porphyrin with calf thymus DNA Dezhampanah, Hamid Bordbar, Abdol-Khalegh Tangestaninejad, Shahram Porphyrin Thermodynamics of binding Optical absorption Fluorescence The equilibrium binding of a new water-soluble tetra-cationic porphyrin, 5-(1-(4-carboxybutyl)‎pyridinium-4-yl)10,15,20-tris(1-methylpyridinium-4-yl)‎porphyrin (5-CBPyP) with calf thymus DNA in comparison with meso-tetrakis(4-N-methyl‎pyridinium)porphyrin (TMPyP) has been studied in 7.5 mM phosphate buffer, pH=7.2; and at various temperatures by UV-Vis absorption, fluorescence spectroscopies and viscosity measurement. The thermodynamic parameters were calculated by van't Hoff equation at various temperatures. The values of -137.13±1.22 kJ/mol and -337.21±4.75 J/mol.K for 5-CBPyP and -159.12±1.22 kJ/mol and -406.11±4.45 J/mol.K for TMPyP, were estimated for enthalpy and entropy changes of interaction, respectively. The data indicate that the process is exothermic and enthalpy driven suggesting that electrostatic forces play a considerable role in the interaction process. The results of spectroscopic techniques and viscosity measurement represent the intercalation mode of binding for both porphyrins and higher binding affinity of TMPyP respect to 5-CBPyP. Atlanta Publishing House LLC 2010-12-22 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/155 10.5155/eurjchem.1.4.307-311.155 European Journal of Chemistry; Vol. 1 No. 4 (2010): December 2010; 307-311 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/155/PDF

oai:ojs.www.eurjchem.com:article/156 2011-04-06T05:38:55Z eurjchem:ART driver

Proton-controlled mechanism for coupling among proton production/consumption reactions in CaCO3-oversaturated waters or calcifying organism-inhabited seawaters Ichikawa, Kazuhiko Acid attack Calcifying organism Phytosymbiont Proton mechanism CaCO3-oversaturated water pH Seawater pH The CaCO3-oversaturated weakly basic water at around pH=8 was proved by the novel simple equations (e.g. log [Ca2+] = -2pH -logPCO2 + 9.94) derived from material energetics and proton-controlled mechanism for coupling among proton/hydroxide production/consumption reactions (e.g. CaCO3 + H+↔HCO3- + Ca2+) in equilibrium with atmospheric carbon dioxide. The cyclic/oscillating variation between pH=8.3 and 8.0 for marine calcifying organism-inhabited paleo and preindustrial seawaters was elucidated by applying the improved proton-controlled mechanismto biochemical reactions in cytoplasts or host tissues of marine calcifying phytoplanktons and phytosymbiont-bearing corals/zooplanktons. It was revealed that photosynthesis enhances biogenic calcificationand vice versa, as the thicker growth of CaCO3-made outer casings causes proton production and photosynthesis continuously needs protons to produce CO2(aq) from major HCO3-. The correlation between calcification and photosynthesis creates a number of stationary states with respect to oscillating pH variation. Marine biogenic calcification reaction releases no CO2 to atmosphere and is no positive feedback to rising atmospheric PCO2 levels. Atlanta Publishing House LLC 2010-12-22 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/156 10.5155/eurjchem.1.4.246-251.156 European Journal of Chemistry; Vol. 1 No. 4 (2010): December 2010; 246-251 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/156/PDF https://www.eurjchem.com/index.php/eurjchem/article/view/156/2520

oai:ojs.www.eurjchem.com:article/161 2011-04-06T06:08:30Z eurjchem:ART driver

Synthesis, characterization and antimicrobial activity evaluation of new imidazo [2,1-b][1,3,4]thiadiazole derivatives Alegaon, Shankar Gaddeppa Alagawadi, Kallanagouda Ramappa Thiazolidinedione Thiadiazole Imidazo[2 1-b][1 3 4]thiadiazoles Antibacterial activity Antifungal activity Rhodanine Imidazo[2,1-b][1,3,4]thiadiazoles (4a-g) were synthesized from 3,4,5-trimethoxy benzoic acid and thiosemicarbazide. Reaction of 4 with Vilsmeier-Haack reagent yielded imidazo [2,1-b][1,3,4] thiadiazole–5-carbaldehyde derivatives (5a-g). Obtained imidazo[2,1-b][1,3,4] thiadia zoles-5-carbaldehydes were subjected to Knoevenagel condensation with 2-(2,4-dioxothia zolidin-3-yl)acetic acid (1) and 2-(4-oxo-2-thioxothiazolidin-3-yl)acetic (2) in the presence of catalytic amount of piperidine and acetic acid to afford imidazo[2,1-b][1,3,4]thiadiazoles (6a-g) and (7a-g), respectively. The structures of the newly synthesized compounds were confirmed by IR, NMR and elemental analyses. All compounds were screened for their antibacterial and antifungal activities. Some of the compounds displayed good antibacterial and antifungal activity. Atlanta Publishing House LLC 2011-03-28 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/161 10.5155/eurjchem.2.1.94-99.161 European Journal of Chemistry; Vol. 2 No. 1 (2011): March 2011; 94-99 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/161/PDF

oai:ojs.www.eurjchem.com:article/165 2011-04-06T05:54:23Z eurjchem:SC driver

Ammonium chloride; as a mild and efficient catalyst for the synthesis of some 2-arylbenzothiazoles and bisbenzothiazole derivatives Maleki, Behrooz Salehabadi, Hafezeh 2-Arylbenzothiazoles Bisbenzothiazole Aldehydes Ammonium chloride 2-Aminothiophenol Mild condition An efficient protocol has been developed for the preparation of a series of 2-arylbenzothiazoles derivatives from condensation of 2-aminothiophenol with aromatic aldehydes using ammonium chloride, which is a very inexpensive, metal-free and readily available reagent. The target compounds were obtained in good to excellent yields (58-92%) under fairly mild reaction conditions at room temperature. Atlanta Publishing House LLC 2010-12-22 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/165 10.5155/eurjchem.1.4.377-380.165 European Journal of Chemistry; Vol. 1 No. 4 (2010): December 2010; 377-380 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/165/PDF

oai:ojs.www.eurjchem.com:article/168 2011-09-30T03:44:50Z eurjchem:ART driver

Synthesis of novel pyrimidine and fused pyrimidine derivatives Mahmoud, Mahmoud Refaee El-Ziaty, Ahmed Kamel Ismail, Mahmoud Fawzy Shiba, Sayed Ahmed s-Benzylthiuronium chloride Activated nitriles Pyrimidines Triazolopyrimidine derivatives Antiviral activity Cytotoxicity 4-Amino-2-(benzylthio)-6-(4-methoxyphenyl)pyrimidine-5-carbonitrile (1) was prepared by treatment of s-benzylthiuronium chloride with 2-(4-methoxybenzylidene)malononitrile in ethanolic sodium hydroxide with hydrazine hydrate to afford the hydrazino derivative 2, which was allowed to react with different electrophilic reagents to give the pyrimidine derivatives 3-12. The proclivity of (E)-2-cyano-3-(4-nitrophenyl)acrylamide (13) towards carbon and nitrogen nucleophiles was also investigated. IR, 1H NMR and mass spectra for all the synthesized compounds were discussed. All derived compounds were investigated for anti avian influenza (H5N1) virus activity and compared with zanamivir as control drug. All the synthesized compounds didn’t possess any antiviral activity. Atlanta Publishing House LLC 2011-09-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/168 10.5155/eurjchem.2.3.347-355.168 European Journal of Chemistry; Vol. 2 No. 3 (2011): September 2011; 347-355 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/168/PDF

oai:ojs.www.eurjchem.com:article/169 2011-06-30T10:44:15Z eurjchem:ART driver

Theoretical and experimental studies on 2-(2-methyl-5-nitro-1-imidazolyl)ethanol Vijaya Chamundeeswari, Sirukarumbur Panduranga Jebaseelan Samuel, Emmanuel Rajan James Sundaraganesan, Namadevan Vibrational spectra NBO analysis TD-DFT UV spectra NMR Metronidazole In this work, we report a combined experimental and theoretical study on molecular structure, vibrational spectra, natural bond orbital (NBO) and UV spectral analysis of [2-(2-methyl-5-nitro-1-imidazolyl) ethanol] (Metronidazole-MTD). The FT-IR solid phase (4000-400 cm-1) liquid phase, and FT-Raman spectra (3500-50 cm-1) of MTD were recorded. The molecular geometry, harmonic vibrational frequencies and bonding features of MTD in the ground state have been calculated using the density functional method B3LYP with 6-311G(d,p) as basis set. The assignments of the vibrational spectra have been carried out with the help of the Gauss view program package. Stability of the molecule arising from hyperconjugative interactions and charge delocalization have been analyzed using natural bond orbital analysis. The results show that charge in electron density (ED) in the σ* and π* antibonding orbitals and second order stabilization energies E2 confirms the occurrence of Intramolecular Charge Transfer (ICT) within the molecule. The UV spectrum was measured in ethanol solution. The energy and oscillator strength calculated by Time-Dependent Density Functional Theory (TD-DFT) results complement the experimental findings. The calculated HOMO and LUMO energies show that charge transfer occurs within the molecule. The 1H and 13C nuclear magnetic resonance (NMR) chemical shifts of the molecule were calculated by the Gauge Independent Atomic Orbital (GIAO) method and compared with experimental results.  Finally the results of calculations were applied to simulate Infrared and Raman spectra of the title compound which show good agreement with observed spectra. Atlanta Publishing House LLC 2011-06-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/169 10.5155/eurjchem.2.2.136-145.169 European Journal of Chemistry; Vol. 2 No. 2 (2011): June 2011; 136-145 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/169/PDF

oai:ojs.www.eurjchem.com:article/170 2011-06-30T10:44:15Z eurjchem:ART driver

Identification and characterization of geometrical isomeric photo degradation product of eprosartan using LC-MS and LC-NMR Shah, Ravi Piyushkumar Sahu, Archana Singh, Saranjit Eprosartan Degradation behaviour Photoisomerization Geometric isomer LC-MS LC-NMR The degradation of eprosartan was evaluated under ICH/WHO prescribed stress conditions. The drug degraded to only one product under photo alkali condition, whereas it was stable to conditions of hydrolysis, oxidation and thermal stress. The drug and its co-eluting product were well separated on RP-HPLC in a gradient mode. Subsequently, LC-MS/TOF and on-line H/D exchange studies were performed on both of them. The two showed same molecular mass, similar fragment ions and even the same number of labile hydrogens indicating the product to be an isomer of the drug. To confirm the same, 1H and COSY LC-NMR studies were carried out by using an enriched sample. Distinguishing behaviour of chemical shifts proved the product to be (Z)-4-((2-butyl-5-(2-carboxy-3-(thiophen-2-yl)prop-1-enyl)-1H-imidazol-1-yl)methyl)benzoic acid. The structure was further supported by differential LC-MS ion intensities of the drug and the product. Atlanta Publishing House LLC 2011-06-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/170 10.5155/eurjchem.2.2.152-157.170 European Journal of Chemistry; Vol. 2 No. 2 (2011): June 2011; 152-157 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/170/PDF

oai:ojs.www.eurjchem.com:article/171 2011-12-31T08:09:40Z eurjchem:ART driver

Novel 4(3H)-quinazolinones containing biologically active thiazole, pyridinone and chromene of expected antitumor and antifungal activities El-Bayouki, Khairy Abdel Hameed Mohsen Basyouni, Wahid Mohamed Mohamed, Yahia Abdel Fatah Aly, Mohsen Mohamed Abbas, Samir Youssef 4(3H)-Quinazolinone Thiazole Pyridinone Chromene Antitumor Antifungal activity Novel 4(3H)-quinazolinone derivatives with biologically active moieties were synthesized. Reactions of 2-cyano-N-(6-iodo-2-methyl-4-oxoquinazolin-3(4H)-yl) acetamide with carbon disulfide, isothiocyanates followed by cycloalkylation afforded acrylamide, 1,3-dithiazole, 1,3-dithiane, thiazole and pyrazole derivatives. The 2-pyridone derivatives were obtained via reaction of cyanoacetamide with some acetylacetone or arylidenes. Cyclocondensation reaction of cyanoacetamide with o-hydroxy aldehydes furnished chromene derivatives. Screening for some selected compounds was carried for their potential antitumor and antifungal activities. 2-Cyano-N-(6-iodo-2-methyl-4-oxoquinazolin-3(4H)-yl)-2-(4-methyl-3-phenyl-thiazol-2(3H)ylidene)-acetamide with 3-side chain incorporated with substituted thiazole moiety was found to be of high to moderate activity towards cells. Also, the latter product showed high activity against Aspergillus ochraceus Wilhelm with inhibition zone (18 mm) compared with (20 mm) Nystatin inhibition zone. Atlanta Publishing House LLC 2011-12-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/171 10.5155/eurjchem.2.4.455-462.171 European Journal of Chemistry; Vol. 2 No. 4 (2011): December 2011; 455-462 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/171/PDF

oai:ojs.www.eurjchem.com:article/172 2011-04-06T05:32:12Z eurjchem:SC driver

Polyethylene glycol (PEG-400) mediated synthesis of quinoxalines Nagarapu, Lingaiah Mallepalli, Raghu Arava, Glory Yeramanchi, Lingappa α-Halo ketones o-Phenylenediamines Quinoxalines Catalyst-free Polyethylene glycol PEG-400 A simple and highly efficient protocol for the synthesis of quinoxaline derivatives from various ortho-phenylenediamines with α-halo ketones under catalyst free conditions is reported by using polyethylene glycol (PEG-400) as an efficient recyclable medium without using any organic co-solvent or additive. This protocol gives wide range of quinoxaline derivatives with high yields. Atlanta Publishing House LLC 2010-09-29 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/172 10.5155/eurjchem.1.3.228-231.172 European Journal of Chemistry; Vol. 1 No. 3 (2010): September 2010; 228-231 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/172/PDF

oai:ojs.www.eurjchem.com:article/175 2011-04-06T06:08:55Z eurjchem:ART driver

One-pot multicomponent route to propargylamines using ferric hydrogensulfate Eshghi, Hossein Zohuri, Gholam Hossein Damavandi, Saman Ferric hydrogensulfate Propargylamine Heterogeneous catalyst Multicomponent reaction One-pot synthesis Propargylic amines The one-pot three-component coupling reaction of phenylacetylene, aldehyde and amine derivatives in the presence of ferric hydrogensulfate, [(Fe(HSO4)3], as an efficient heterogeneous catalyst is reported. The catalyst displayed high activity and afforded the corresponding propargylamines in good to excellent yields. This method provides the wide range of substrate applicability. Heterogeneous nature of the catalyst made it reusable for further chemical reactions. Atlanta Publishing House LLC 2011-03-28 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/175 10.5155/eurjchem.2.1.100-103.175 European Journal of Chemistry; Vol. 2 No. 1 (2011): March 2011; 100-103 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/175/PDF

oai:ojs.www.eurjchem.com:article/182 2012-03-31T06:42:45Z eurjchem:REW driver

Potassium hydrogen sulfate: An efficient catalyst in organic reactions Baghernejad, Bita Catalyst Non-toxic Applications Organic reactions Organic transformations Potassium hydrogen sulfate Potassium hydrogen sulfate, KHSO4, has been used in many organic preparations as a good solid catalyst. The KHSO4 has received considerable attention since it is an inexpensive, eco-friendly, highly reactive, easy to handle and non-toxic catalyst for various organic transformations, affording the corresponding products in excellent yields with high selectivity. We wish to report some applications of this catalyst in organic reactions. Atlanta Publishing House LLC 2012-03-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/182 10.5155/eurjchem.3.1.125-128.182 European Journal of Chemistry; Vol. 3 No. 1 (2012): March 2012; 125-128 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/182/PDF

oai:ojs.www.eurjchem.com:article/183 2011-04-06T06:07:30Z eurjchem:ART driver

Thermomechanical studies of thermally stable metal-containing epoxy polymers from diglycidyl ether of bisphenol A and amino-thiourea metal complexes Saeed, Sohail Rashid, Naghmana Jones, Peter Hussain, Rizwan Amino-thiourea derivatives Metal-containing epoxy polymers Dynamic mechanical analysis Differential scanning calorimeter Thermogravimetric analysis DGEBA New thermally stable epoxy polymers containing copper and nickel ions have been prepared by curing diglycidyl ether of bisphenol A (DGEBA) with amino-thiourea metal complexes. Characterization of the metal complexes was carried out using infrared spectroscopy, elemental analysis and mass spectrometry. Determination of the optimum value of the epoxy/thiourea metal complex ratio was studied by means of differential scanning calorimetry. This method is based on the search for the maximum enthalpy change. The properties of the resulting metal-containing epoxy polymers were investigated with respect to glass transition temperature, thermal stability, tensile strength, and viscoelastic properties. Introduction of metal ions, especially the copper ion, into the polymer matrices produced polymers with good thermal stability and mechanical properties. The polymer showed good thermal stability compared to the DGEBA-DDM (DDM: 4,4’-diaminodiphenylmethane) system. The copper-containing epoxy polymer obtained at a mole ratio of copper complex:DGEBA (24:100) showed a 2.6% weight loss after heating at 400 °C and had a storage modulus of 6080 MPa at 125 °C, which is comparable to the epoxy-DDM system. Atlanta Publishing House LLC 2011-03-28 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf chemical/x-cif https://www.eurjchem.com/index.php/eurjchem/article/view/183 10.5155/eurjchem.2.1.77-82.183 European Journal of Chemistry; Vol. 2 No. 1 (2011): March 2011; 77-82 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/183/PDF https://www.eurjchem.com/index.php/eurjchem/article/view/183/2533

oai:ojs.www.eurjchem.com:article/184 2011-09-30T03:44:50Z eurjchem:ART driver

Synthesis and antimicrobial activity of novel oxime derivatives of phenothiazine Barve, Ashutosh Noolvi, Malleshappa Subhedar, Niharika Gupta, Vishnu Dev Bhatia, Gaurav Coumarin Oxime Phenothiazine Antimicrobial activity Anti-bacterial activity Anti-fungal activity A series of 4-methyl-2-oxo-pyranyl-phenothiazines (IIIa-j) followed by 4-methylpyrano-(2, 3-β)-phenothiazine-2(11H)-one oxime (IVa-j) were synthesized by using 7-hydroxy-4-methylcoumarin (I). Further reaction of (I) was carried out with substituted aromatic amines (a-j) to convert into 7-arylamino-4-methyl-coumarin (IIa-j). Additionally (IIa-j) was treated with sulphur in presence of iodine to obtain a series of novel 4-methyl-2-oxo-pyranyl-phenothiazine (IIIa-j) derivatives, which on treatment with hydroxylamine hydrochloride afforded the title compounds i.e. 4-methylpyrano-(2,3-β)-phenothiazine-2(11H)-one oxime (IVa-j). The structures of these compounds were confirmed by IR, NMR and Mass spectral analysis. The newly synthesized compounds were evaluated for antibacterial and antifungal activity. The results show that compound IIIa, IIIe, IIIh, IIIj, IVa, IVi and IVj exhibited moderate to good antibacterial and antifungal activity at 5-100 mcg/mL. Atlanta Publishing House LLC 2011-09-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/184 10.5155/eurjchem.2.3.388-393.184 European Journal of Chemistry; Vol. 2 No. 3 (2011): September 2011; 388-393 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/184/PDF

oai:ojs.www.eurjchem.com:article/185 2011-04-06T05:45:13Z eurjchem:ART driver

Synthesis of new 4,6-disubstituted-1,3-5-triazin-2-yloxy esters and N-hydroxyamides Mikhaylichenko, Svetlana Kvak, Olga Dalili, Shadi Zaplishny, Vladimir 1 3 5-Triazines Alkylation Transesterification Hydroxamic acids Synthesis A convenient method for synthesis of new sym-triazine ester and hydroxamate derivatives has been developed. Various reaction conditions were studied and optimized, and a series of new 1,3,5-triazine based esters and N-hydroxyamides were obtained with good yields (38-80%). The reaction between oxo-derivatives of 4,6-disubstituted-1,3,5-triazines and halogenated carboxylic esters derivatives using  Cs2CO3 as a catalyst was found to be the most convenient method for 4,6-disubstituted-1,3,5-triazine-2-yloxy esters  synthesis. These 1,3,5-triazin based esters served as precursors for the synthesis of 4,6-disubstituted-1,3,5-triazin-2-yloxy-N-hydroxybutanamides using solution of hydroxylamine hydrochloride in dry methanol and KOH at room temperature.  Structures of the newly synthesized compounds were obtained by 1H NMR, 13C NMR, MS, IR spectral data and elemental analysis. Atlanta Publishing House LLC 2010-12-22 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/185 10.5155/eurjchem.1.4.302-306.185 European Journal of Chemistry; Vol. 1 No. 4 (2010): December 2010; 302-306 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/185/PDF

oai:ojs.www.eurjchem.com:article/187 2011-04-06T05:39:51Z eurjchem:ART driver

Optical properties of sol-gel materials doped with ethyl 2-(7-hydroxy-2-oxo-2H-chromen-4-yl) acetate Ahmed, Gyulyay Petkov, Ivan Gutzov, Stoyan Coumarin Optical spectroscopy Sol-gel method Transparent sol-gel glassy monoliths doped with coumarin molecules [ethyl 2-(7-hydroxy-2-oxo-2H-chromen-4-yl) acetate] displaying a strong blue luminescence are characterized by optical spectroscopy, X-Ray diffraction, SEM and TG/FT-IR spectroscopy. The UV/Vis, luminescence and excitation spectra of the doped sol-gel materials and of ethanol solutions of coumarin are discussed. The coumarin optical spectra are used as a probe for incorporation in the gel structure. Atlanta Publishing House LLC 2010-12-22 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/187 10.5155/eurjchem.1.4.259-261.187 European Journal of Chemistry; Vol. 1 No. 4 (2010): December 2010; 259-261 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/187/PDF

oai:ojs.www.eurjchem.com:article/189 2019-12-31T10:22:23Z eurjchem:ART driver

An imidazole based colorimetric sensor for fluoride anion Goswami, Shyamaprosad Chakrabarty, Rinku Anion recognition Colorimetric Fluorescent Fluoride Imidazole based receptor Steric hindrance Nine 2,3,5-triphenylimidazole derivatives having nitro and/or OH groups at their phenyl groups as receptors have been designed and synthesized for the colorimetric detection of F- ion, among which receptor (1) having a nitro group at the para position of the 2-phenyl group with respect to the imidazole moiety shows colorimetric responses (yellow to red) in acetonitrile-water (9:1, v:v) mixture towards F- anion selectively among other anions studied. Here nitro group acts as a signaling unit and OH and NH of imidazole moieties act as binding sites respectively.   Atlanta Publishing House LLC 2011-09-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/189 10.5155/eurjchem.2.3.410-415.189 European Journal of Chemistry; Vol. 2 No. 3 (2011): September 2011; 410-415 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/189/PDF https://www.eurjchem.com/index.php/eurjchem/article/view/189/2522

oai:ojs.www.eurjchem.com:article/191 2011-04-06T06:08:03Z eurjchem:ART driver

Simultaneous removal of chromotrope 2B and radionuclides from mixed radioactive process wastewater using organo-bentonite Shakir, Kamal Ghoneimy, Hussein Fouad Hennawy, Ibtisam Tadros Elkafrawy, Ahmed Faouzy Beheir, Shokry Gad Elrab Refaat, Mamdoh CTAB-bentonite Chromotrope 2B Radionuclides Adsorption Radioactive wastewater Wastewater treatment The simultaneous removal of cationic radionuclides, 137Cs(I), 60Co(II) and 152+154Eu(III), and a chemically toxic anionic pollutant, the analytical reagent chromotrope 2B (C2B), from simulated mixed radioactive process wastewater (MRPWW) has been investigated using bentonite modified with cetyltrimethylammonium bromide. Modification was confirmed by elemental analysis, X-ray diffraction and infrared spectroscopy. Bentonite partially modified to 78% of the cation exchange capacity (PMB) was found capable to adsorb adequately both C2B and the radionuclides from aqueous solutions. Detailed batch kinetics and isotherm studies for removal of C2B singly and the radionuclides simultaneously were performed. The C2B and radionuclides kinetics conform to pseudo-first-order rate equation and the adsorption isotherms are treated with Freundlich and Langmuir models. Thermodynamic parameters were evaluated. Results suggest physisorption and ion-exchange as the principal uptake mechanism for C2B and the radionuclides, respectively. High simultaneous removal was obtained for C2B (≈ 100%) and each of the test radionuclides (>99%) from the simulated MRPWW. Atlanta Publishing House LLC 2011-03-28 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/191 10.5155/eurjchem.2.1.83-93.191 European Journal of Chemistry; Vol. 2 No. 1 (2011): March 2011; 83-93 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/191/PDF

oai:ojs.www.eurjchem.com:article/193 2011-12-31T08:09:40Z eurjchem:ART driver

Synthesis and reactions of (Z)-2-imino-5-(3,4,5-trimethoxy benzylidene)thiazolidin-4(H)one Mahmoud, Mahmoud Refaee Madkour, Hassan Mohamed Fawzy El-Bordany, Eman Abd El-Fattah Soliman, El-Sayed Ahmed Iminothiazolidinone derivatives Grignard reagents Imidazolidinone derivative 2-Thiazolidin-4-one Nitrogen nucleophiles Activated nitriles 5-Arylmethylene-2-imino-4-oxo-2-thiazolidine 3 was obtained as the sole product from the reaction of α-cyano-3,4,5-trimethoxy cinnamonitrile and/or ethyl-α-cyano-3,4,5-trimethoxy cinnamate (1a,b) with 2-imino-4-oxo-2-thiazolidine 2. The reaction of 3 with benzyl amine gave the imidazolidin-4(H)one derivative 4 while with hydrazine hydrate afforded the dimeric product 5. Also, reaction of thiazolidinone derivative 3 with piperidine gave thiazol-4(5H)one derivative 6 which on treatment with Grignard reagent and active methylene compounds afforded thiazolidin-4-one derivatives 7-9, respectively. Compound 6 was converted to the potassium salt 10 which treated with acetic acid, ethyl chloroacetate and furoyl chloride to give the compounds 11-13, respectively. The structures of all new compounds were evidenced by microanalytical data and spectral data. Atlanta Publishing House LLC 2011-12-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/193 10.5155/eurjchem.2.4.475-479.193 European Journal of Chemistry; Vol. 2 No. 4 (2011): December 2011; 475-479 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/193/PDF

oai:ojs.www.eurjchem.com:article/194 2011-04-06T05:48:46Z eurjchem:ART driver

Decatungstodivanadogermanic heteropoly acid (H6GeW10V2O40.22H2O): A novel, green and reusable catalyst for efficient acetylation of alcohols and phenols under solvent-free conditions Farhadi, Saeid Panahandehjoo, Somayeh Acetylation Alcohols Phenols Decatungstodivanadogermanic acid Heterogeneous catalyst Solvent-free conditions Decatungstodivanadogermanic acid (H6GeW10V2O40.22H2O) was used as a novel and green heterogeneous catalyst for the acetylation of hydroxy compounds under solvent-free conditions at room temperature. Efficient and selective acetylation of various alcohols and phenols was conducted with acetic anhydride as an acetylating agent over H6GeW10V2O40.22H2O under solvent-free conditions. All acetylated products were selectively obtained in excellent yields with very short reaction times. The reaction times were longer for the acetylation of phenols than for alcohols, so that an alcoholic OH group could be selectively acetylated in the presence of a phenolic OH group by the appropriate choice of reaction time. The catalyst can be recycled several times without observable loss of activity and selectivity. Atlanta Publishing House LLC 2010-12-22 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/194 10.5155/eurjchem.1.4.335-340.194 European Journal of Chemistry; Vol. 1 No. 4 (2010): December 2010; 335-340 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/194/PDF

oai:ojs.www.eurjchem.com:article/195 2011-04-06T05:47:43Z eurjchem:ART driver

QSAR rationales for the 1,2-diarylcyclopentenes as prostaglandin EP1 receptor antagonists: Potentially useful in the treatment of inflammatory pain Sharma, Brij Kishore Pilania, Pradeep Singh, Prithvi 1 2-Diarylcyclopentenes EP1 receptor antagonists Dragon descriptors QSAR CP-MLR Partial least square analysis The EP1 receptor inhibitory activity of 1,2-diarylcyclopentene derivatives have been quantitatively analyzed in terms of Dragon descriptors. The derived QSAR models have provided rationales to explain the EP1 receptor inhibitory activity of 1,2-diarylcyclopentene derivatives. The 2D-autocorrelation descriptors (MATS4e, MATS5e, MATS7v, GATS5e and GATS7v) have highlighted the role of atomic properties in respective lags of autocorrelations to explain the biological actions of 1,2-diarylcyclopentene analogues. Presence of fluorine atom (nF) and smaller distance between N and O atoms (T(N..O)) in molecular structures, in addition to Kier-Hall electrotopological states (Ss) have also shown prevalence to optimize the EP1 receptor inhibitory activity. Partial least square analysis has confirmed the dominance of information content of the combinatorial protocol in multiple linear regression identified descriptors. Applicability domain analysis revealed that the suggested model matches the high quality parameters with good fitting power and capability of assessing external data. All the compounds are within the applicability domain of the proposed model and were evaluated correctly. Atlanta Publishing House LLC 2010-12-22 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/195 10.5155/eurjchem.1.4.325-334.195 European Journal of Chemistry; Vol. 1 No. 4 (2010): December 2010; 325-334 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/195/PDF

oai:ojs.www.eurjchem.com:article/201 2011-04-06T06:10:52Z eurjchem:SC driver

Synthesis of 8-hydroxy-6-methoxy-3-pentyl-1H-isochromen-1-one from Tessmannia densiflora Saeed, Aamer Isocoumarin Tessmannia densiflora 3 5-Dimethoxyhomophthalic acid Antimalarial 5-Dimethoxyhomophthalic anhydride Mechanism The synthesis of 8-hydroxy-6-methoxy-3-pentyl-1H-isochromen-1-one (1) isolated from the stem and root bark extracts of Tessmannia densiflora has been described. The reaction of 3,5-dimethoxyhomophthalic anhydride (2) with hexanoyl chloride in the presence of 1,1,3,3-tetramethylguanidine and triethylamine afforded 6,8-dimethoxy-3-pentylisocoumarin (3). Regioselective demethylation of the latter using anhydrous aluminum chloride furnished the title isocoumarin (1). Atlanta Publishing House LLC 2011-03-28 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/201 10.5155/eurjchem.2.1.117-119.201 European Journal of Chemistry; Vol. 2 No. 1 (2011): March 2011; 117-119 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/201/PDF

oai:ojs.www.eurjchem.com:article/205 2011-06-30T10:44:15Z eurjchem:ART driver

An improved synthesis of the alkaloid Luotonin-A employing ionic liquid and water as key solvents Potewar, Taterao Marutao Kathiravan, Muthu Kumaradoss Chothe, Aparna Surendra Srinivasan, Kumar Venkatram Ionic liquids Luotonin A Water Pyrroloquinazoline Volatile organic compounds Anticancer activity Luotonin A is among the first known natural product possessing the heteroaromatic pyrroloquinazoline ring system. Although many syntheses have been reported for this compound, but they all have one or the other draw back such as a large number of steps, use of hazardous reagents like sodium hydride, low temperature reactions, and lengthy reaction time. Herein we report the synthesis of luotonin A achieved in five steps in which, two of the steps involved green solvents such as an ionic liquid and water as reaction media. In particular, we have achieved the reaction steps 1 and 3 involving the green solvents in much shorter reaction time than hitherto reported. Atlanta Publishing House LLC 2011-06-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/205 10.5155/eurjchem.2.2.235-237.205 European Journal of Chemistry; Vol. 2 No. 2 (2011): June 2011; 235-237 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/205/PDF

oai:ojs.www.eurjchem.com:article/206 2011-06-30T10:44:15Z eurjchem:ART driver

Synthesis and anti-tubercular activity of novel pyrazol-5(H)-one derivatives Raval, Jignesh Priyakant Shah, Arpita Bharatbhai Patel, Nilesh Hasmukhbhai Patel, Hemul Venubhai Patel, Pradip Shantilal Bhatt, Kashyap Kanaiyalal Desai, Kishor Ratilal Isonicotinohydrazide Pyrazol-5(H)-ones Anti-tubercular activity Anti-mycobacterial activity Mycobacterium tuberculosis M. tuberculosis H37Rv In the present investigation, a series of 1-isonicotinoyl-3-methyl-4-(2-(substituted-phenyl)hydrazono)-1H-pyrazol-5(H)-ones were synthesized by the reaction between isonicotinohydrazide with substituted ethylacetoacetate derivatives using acetic acid as solvent which yielded substituted pyrazol-5(H)-one derivatives. Newly synthesized compounds were tested for their in vitro anti-tubercular activity against Mycobacterium tuberculosis H37Rv using the BACTEC 460 radiometric system. Among the synthesized compounds, 4-(2-(2,6-dichlorophenyl)hydrazono)-1-isonicotinoyl-3-methyl-1H-pyrazol-5(4H)-one and 4-(2-(1-isonicotinoyl-3-methyl-5-oxo-1H-pyrazol-4(5H)-ylidene)hydrazinyl) benzene-sulfonamide were found to be more active agent against M. tuberculosis H37Rv with minimum inhibitory concentration of 0.0034, 0.0032 µM at actual MIC 1.66 and 1.64 µg/mL, respectively. Atlanta Publishing House LLC 2011-06-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/206 10.5155/eurjchem.2.2.238-242.206 European Journal of Chemistry; Vol. 2 No. 2 (2011): June 2011; 238-242 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/206/PDF

oai:ojs.www.eurjchem.com:article/207 2011-04-06T05:42:05Z eurjchem:ART driver

Synthesis, characterization and crystal structure of ethyl 4-(3-chloro benzamido)benzoate Saeed, Aamer Rafique, Hummera Flörke, Ulrich Ethyl 4-(3-chlorobenzamido)benzoate Crystal structure Synthesis Characterization The title compound was efficiently synthesized in two steps starting from esterification of 4-aminobenzoic acid followed by amidation with 3-chlorobenzoyl chloride in dry tetrahydrofuran. The structure was confirmed by spectroscopic data and elemental analysis. The molecular structure was determined from single crystal X-ray diffraction data. It crystallizes in the triclinic space group P-1 with Z = 2 and unit cell dimensions a = 5.2941(15) Å, b = 8.157(2) Å, c = 16.238(4) Å, α = 82.682(6)°, β = 84.481(6)°, γ = 80.100(6)° and V = 683.2(3) Å3. Atlanta Publishing House LLC 2010-12-22 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf application/octet-stream https://www.eurjchem.com/index.php/eurjchem/article/view/207 10.5155/eurjchem.1.4.289-290.207 European Journal of Chemistry; Vol. 1 No. 4 (2010): December 2010; 289-290 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/207/PDF https://www.eurjchem.com/index.php/eurjchem/article/view/207/2523

oai:ojs.www.eurjchem.com:article/208 2011-04-06T06:03:47Z eurjchem:ART driver

Synthesis and antimicrobial activities of some novel bis-pyrazole derivatives containing a hydrophosphoryl unit Abdel-Aziz, Salah Abdel-Ghaffar Ali, Tarik El-Sayed El-Mahdy, Kamilia Mohamed Abdel-Karim, Somaia Mohamed Phosphonicdihydrazones Hydro-phosphoryl Vilsmeier-Haack reaction Bis-pyrazoles Sulfur-phosphorus heterocycles Antimicrobial activity Vilsmeier-Haack reaction conditions were applied on some methyl ketone aryl phosphonicdihydrazones to yield some interesting bis-pyrazole derivatives containing a hydro-phosphoryl unit. Bis-{4-formyl-3-aryl-1H-pyrazol-1-yl}phosphine oxides (4a,b) were condensed with some nucleophiles such as aniline, phenacyltriphenylphosphonium bromide and 4-phenylthiosemicarbazide followed by treatment with thioglycolic acid, diethyl phosphite and/or acetic anhydride to yield a novel class of bis-pyrazoles containing sulfur and phosphorus derivatives. Most of the newly synthesized compounds were evaluated for their in vitro antimicrobial activities. Atlanta Publishing House LLC 2011-03-28 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/208 10.5155/eurjchem.2.1.25-35.208 European Journal of Chemistry; Vol. 2 No. 1 (2011): March 2011; 25-35 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/208/PDF

oai:ojs.www.eurjchem.com:article/211 2011-04-06T05:39:20Z eurjchem:ART driver

Chitosan as an eco-friendly heterogeneous catalyst for Michael type addition reactions. A simple and efficient route to pyridones and phthalazines Khalil, Khaled Al-Matar, Hamad Elnagdi, Mohamed Chitosan Enaminone Michael addition Pyridone Pthalazine Benzylidene Depending on their nature, nitrile activated methylene compounds add readily to β-enaminones in presence of chitosan to yield dienamides, pyridones or pyridine thiones. The dienamides, formed in this manner, can be readily converted to pyridones by stirring in refluxing acetic acid. Reaction of pyridazinones with a mixture containing benzaldehyde, malononitrile and chitosan affords phthalazines that are also produced by reaction of pyridazinone with benzylidene-malononitrile. Atlanta Publishing House LLC 2010-12-22 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/211 10.5155/eurjchem.1.4.252-258.211 European Journal of Chemistry; Vol. 1 No. 4 (2010): December 2010; 252-258 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/211/PDF

oai:ojs.www.eurjchem.com:article/221 2011-04-06T05:53:04Z eurjchem:ART driver

Chiral Cu(II) salen complexes catalyzed aerobic oxidative biaryl coupling-probing the reaction by EPR Sabarinathan, Subbaramanian Vasuki, Gnanasambandam Rao, Pillutla Sambasiva Biaryl coupling Chiral copper salen complexes Cross coupling BINOL Aerobic oxidation EPR Aerobic oxidative coupling of 2-naphthol to 1,1'-binaphthyl-2,2'-diol has been achieved using chiral/achiral copper salen complexes as catalyst. Moderate enantioselectivity was obtained for the reaction of 2-napthol with a coordinating substituent with a chiral salen complex. Unsubstituted 2-naphthol resulted in racemic 1,1'-binaphthyl-2,2'-diol only with all chiral complexes. Electron paramagnetic resonance spectroscopy has been used to understand the factors influencing the asymmetric induction. Atlanta Publishing House LLC 2010-12-22 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/221 10.5155/eurjchem.1.4.360-367.221 European Journal of Chemistry; Vol. 1 No. 4 (2010): December 2010; 360-367 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/221/PDF https://www.eurjchem.com/index.php/eurjchem/article/view/221/2531

oai:ojs.www.eurjchem.com:article/224 2011-04-06T05:46:48Z eurjchem:ART driver

Determination of enantiomeric excess of leucine and valine by X-ray powder diffraction Tadeusiak, Elżbieta Kruszynski, Rafal Trzesowska-Kruszynska, Agata Sieranski, Tomasz Lewinski, Bartlomiej Leucine Valine Enantiomeric excess X-ray powder diffraction Two amino acids, leucine and valine, were studied by X-ray powder diffraction (XRPD). The linear correlations between intensity of racemate (decrease) or enantiomer (increase) and enantiomeric excesses were observed in each case. Atlanta Publishing House LLC 2010-12-22 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/224 10.5155/eurjchem.1.4.319-321.224 European Journal of Chemistry; Vol. 1 No. 4 (2010): December 2010; 319-321 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/224/PDF

oai:ojs.www.eurjchem.com:article/227 2011-06-30T10:44:15Z eurjchem:SC driver

Synthesis and electrochemistry of dimanganese(II) complexes of phenol-based dinucleating ligands with four methoxyethyl chelating arms Nakayama, Yuuki Unoura, Kei Igarashi, Yasuhiro Hossain, Md. Jamil Sakiyama, Hiroshi Dimanganese(II) complex Dinucleating ligand Electrochemistry p-Substituent DFT Redox potential Dimanganese(II) complexes [Mn2(bonp)(PhCO2)2]PF6 (1) and [Mn2(bocp)(PhCO2)2]PF6 (2) were synthesized with p-nitro- and p-chloro-substituted phenol-based dinucleating ligands bonp- [2,6-bis[bis(2-methoxyethyl)aminomethyl]-4-nitrophenolate anion] and bocp- [4-chloro-2,6-bis[bis(2-methoxyethyl)aminomethyl]phenolate anion], respectively, with the aim of controlling the redox potentials of the dimanganese center by changing the p-substituents in the dinucleating ligands. Cyclic voltammograms of 1 and 2 showed quasi-reversible oxidation processes, assigned to MnIIMnII/MnIIMnIII, at 1.17 and 1.00 V vs. Ag/AgCl, respectively. Compared to the previous p-methyl complex [Mn2(bomp)(PhCO2)2]PF6 (3) [bomp–: 2,6-bis[bis(2-methoxyethyl)aminomethyl]-4-methylphenolate anion] (0.96 V vs. Ag/AgCl), the order of the potentials was 1(-NO2) > 2(-Cl) > 3(-CH3). Thus, the redox potentials of the dimanganese centers were controlled by the p-substituents in the dinucleating ligands. Atlanta Publishing House LLC 2011-06-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/227 10.5155/eurjchem.2.2.266-268.227 European Journal of Chemistry; Vol. 2 No. 2 (2011): June 2011; 266-268 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/227/PDF

oai:ojs.www.eurjchem.com:article/228 2011-06-30T10:44:15Z eurjchem:ART driver

Green methodologies in organic synthesis: Microwave assisted solvent- and catalyst-free synthesis of enaminones and their conversion into 1,3,5-trisubstituted benzenes as well as 3-aroyl-6-substituted pyridines El-Apasery, Morsy Ahmed Al-Mousawi, Saleh Mohamed Elnagdi, Mohamed Helmy Enaminone Solvent-free Green chemistry Dye intermediates Microwave irradiation 1 3 5-trisubstituted benzenes Enaminones were obtained in good yields via condensing methyl ketones with (N,N-dimethylformamide dimethyl acetal) DMF-DMA under microwave irradiation in absence of solvent. These enaminones were readily converted into 1,3,5-trisubstituted benzenes. Reacting enaminones in presence of ammonium acetate has afforded pyridine derivatives. Atlanta Publishing House LLC 2011-06-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf application/pdf application/octet-stream https://www.eurjchem.com/index.php/eurjchem/article/view/228 10.5155/eurjchem.2.2.168-172.228 European Journal of Chemistry; Vol. 2 No. 2 (2011): June 2011; 168-172 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/228/PDF https://www.eurjchem.com/index.php/eurjchem/article/view/228/2526 https://www.eurjchem.com/index.php/eurjchem/article/view/228/2527

oai:ojs.www.eurjchem.com:article/229 2011-04-06T06:05:59Z eurjchem:ART driver

Tritium label in studying sorption of humic substances by carbon-based nanomaterials Chernysheva, Maria Badun, Gennadii Humic substances Tritium label Carbon-based nanomaterials Adsorption Radiotracer method Fulvic acids Sorption capacity of single-walled carbon nanotubes, detonated nanodiamonds and graphene to humic substances was studied by radiotracer method. Tritium labeled brown coal humic acids and fulvic acids separated from Suwannee River were used as sorbates. Adsorption isotherms were described by Langmuir equation. It was found that, for all tested carbon-based nanomaterials, adsorption of coal humic acids is higher than of river fulvic acids. Adsorption capacity of nanomaterials in attitude to humic substances was changed in the order, nanodiamonds < single-walled nanotubes < graphene. Composites of humic substances with carbon-based nanomaterials were subjected to dynamic light scattering analysis. Atlanta Publishing House LLC 2011-03-28 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/229 10.5155/eurjchem.2.1.61-64.229 European Journal of Chemistry; Vol. 2 No. 1 (2011): March 2011; 61-64 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/229/PDF bf570223f41d9d6e2977eff1165de376