2024-03-28T09:56:41Z
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2011-04-05T15:59:16Z
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Synthesis and studying the antitumor activity of novel 5-(2-methylbenzimidazol-5-yl)-1,3,4-oxadiazole-2(3H)-thiones
Galal, Shadia Ahmed
Abdelsamie, Ahmed S.
Rodriguez, Mireya L.
Kerwin, Sean M.
El Diwani, Hoda I.
Salicylate
Hydrogen bonding
DFT-Molecular dynamics
Vibrational spectroscopy
Relaxation spectroscopy
The influence of the incorporation of 1,3,4-oxadiazole ring into 2-methyl-1H-benzimidazole derivatives producing a series of substituted 5(6)-(2-methylbenzimidazol-5-yl)-1,3,4-oxadiazoles on the antitumor activity was studied in this study. The antitumor activity of the new compounds was tested against breast cancer cell line MCF-7 and lung cancer cell line A549. S-5-(2-methyl-1H-benzo[d]imidazol-5-yl)-1,3,4-oxadiazol-2-yl 2-nitrobenzenesulfonothioate (9) showed potent activity against both MCF-7 and A549 cell lines. Whereas, compounds 7, 11-13 and 15-17 have moderate growth inhibitory activity on the two cell lines.
Atlanta Publishing House LLC
2010-06-15
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://www.eurjchem.com/index.php/eurjchem/article/view/1
10.5155/eurjchem.1.2.67-72.1
European Journal of Chemistry; Vol. 1 No. 2 (2010): June 2010; 67-72
2153-2257
2153-2249
eng
https://www.eurjchem.com/index.php/eurjchem/article/view/1/PDF