2026-04-21T01:28:52Z https://www.eurjchem.com/index.php/eurjchem/oai

oai:ojs.www.eurjchem.com:article/1005 2014-06-30T08:07:06Z eurjchem:ART driver

Application of π receptors to the spectrophotometric determination of naftidrofuryl oxalate in pure form and its pharmaceutical preparation Younes, Kareem Mahmoud Basha, Mai Adel Salem, Maissa Yacoub Chloranilic acid Tetracyanoethylene Naftidrofuryl oxalate Pharmaceutical preparation Charge transfer complexation 2 3-Dichloro-5 6-dicyano-1 4-benzoquinone Three different spectrophotometric methods are developed for the determination of naftidrofuryl oxalate (NAF) in pure form and its pharmaceutical preparation. The methods are based on charge transfer complexation reactions of NAF as n-electron donor with either p-chloranilic acid (PCA) or 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) or tetracyano ethylene (TCNE) as π-receptors to give highly colored anion radicals species. The colored products were quantified spectrophotometrically at 515, 588 and 396 nm in PCA, DDQ and TCNE methods, respectively. Under the optimized experimental conditions, Beer's law is obeyed over the concentration ranges of 75.0-300.0, 25.0-150.0 and 15.0- 50.0 μg/mL NAF for PCA, DDQ and TCNE methods, respectively. The proposed methods were applied successfully to the determination of NAF in pure form and its commercial tablets with good accuracy and precision. Statistical comparison of the results was performed using Student's t-test and F-ratio at 95% confidence level, showing that there is no significant difference between the reference and the proposed methods with regard to accuracy and precision. Further, the validity of the proposed methods was confirmed by standard addition technique. Atlanta Publishing House LLC 2014-06-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/1005 10.5155/eurjchem.5.2.272-276.1005 European Journal of Chemistry; Vol. 5 No. 2 (2014): June 2014; 272-276 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/1005/pdf_1005