2024-03-28T20:49:43Z
https://www.eurjchem.com/index.php/eurjchem/oai
oai:ojs.www.eurjchem.com:article/1010
2014-06-30T08:07:08Z
eurjchem:ART
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Computational study and antimicrobial activity of few Dapsone Schiff base derivatives
Al-Masoudi, Wasfi Abood
Al-Tememy, Tamadher Mohammad
Al-Assadi, Rafid Hmedan
DFT
Dapsone
Schiff base
Antimicrobial
NMR spectroscopy
Computational study
Condensation of 4,4-diaminodiphenyl sulfone (Dapsone) with aliphatic and aromatic aldehydes yielded a few Schiff base derivatives in good yields. The optimized structural parameters (bond lengths and bond angles) of three azomethine compounds have been obtained by using the GAUSSIAN 09 program package. Conformer of compound 1 has the highest energy, which has less stability than compounds 2 and 3 at the same model. The synthesized compounds were screened for antibacterial activity against Staphylococcus aureus, Escherichia coli, Bacillus subtilis and fungicidal activity against Aspergillus niger and Candida albicans. All compounds exhibited potent antibacterial and antifungal activity with the reference standard ciprofloxacin and Amphotericin B, respectively.
Atlanta Publishing House LLC
2014-06-30
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://www.eurjchem.com/index.php/eurjchem/article/view/1010
10.5155/eurjchem.5.2.351-355.1010
European Journal of Chemistry; Vol. 5 No. 2 (2014): June 2014; 351-355
2153-2257
2153-2249
eng
https://www.eurjchem.com/index.php/eurjchem/article/view/1010/pdf_1010