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Synthesis and evaluation of antibacterial activity for a series of N-phthaloylglycine derivatives
Begum, Samreen
Nizami, Shaikh Sirajuddin
Saied, Sumayya
Shahid, Syed Muhammad
Basha, Fatima Zehra
Antibacterial
Benzimidazole
Phthaloylglycine derivatives
Schotten-Baumann reaction
Methicillin-resistant Staphylococcus aureus
Vancomycin-resistant Staphylococcus aureus
Two series of N-phthaloylglycine derivatives were synthesized under Schotten-Baumann conditions. The first series consists of N-phthaloylglycine amides (4a-h), and the second one consists of benzimidazole derivatives of N-phthaloylglycine (6a-d). All the synthesized analogues were evaluated for their in vitro antimicrobial activity by using disc diffusion method. In the first series, compounds 4h (MIC, 0.5 mg/L), 4a (MIC, 0.6 mg/L), and 4e (MIC, 0.7 mg/L) were found to be the most potent against vancomycin-resistant Staphylococcus aureus (VRSA). Furthermore, three compounds i.e. 4g (MIC, 0.8 mg/L), 6b (MIC, 1.5 mg/L), and 4h (MIC, 1.6 mg/L) displayed good activity against methicillin-resistant Staphylococcus aureus (MRSA). All the synthesized compounds exhibited a wide range of antibacterial activity against all of the Staphylococcus aureus resistant strains tested. The structures of the synthesized compounds were characterized by IR, 1H NMR, 13C NMR and MS (EI).
Atlanta Publishing House LLC
2014-12-31
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://www.eurjchem.com/index.php/eurjchem/article/view/1077
10.5155/eurjchem.5.4.557-562.1077
European Journal of Chemistry; Vol. 5 No. 4 (2014): December 2014; 557-562
2153-2257
2153-2249
eng
https://www.eurjchem.com/index.php/eurjchem/article/view/1077/pdf_1077