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2014-09-30T03:41:50Z
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A study of coupling reaction to synthesize diphenylmethane derivatives
Bhatti, Huma Aslam
Zaheer, Qurat-Ul-Ain
Khatoon, Memoona
Light, Mark Edward
Hameed, Abdul
Benzyl alcohol
Thionyl chloride
Coupling reaction
Halogenating agents
Phosphorus tribromide
Diphenylmethane derivative
The class of compounds having diphenylmethane framework occupy a distinct place in natural bioactive compounds and also serve as useful intermediates in various commercially important synthetic molecules. Conventionally, Friedel-Craft type reactions were used to synthesize such diphenylmethane derivatives. However, herein we report a unique approach in which, two benzyl alcohol molecules were coupled in the presence of different halogenating agents (SOCl2, PBr3 and MeSO2Cl) to afford the desired diphenylmethane derivative, bis(2,4-bis(benzyloxy)-5-methoxyphenyl)methane. It has been found that the coupling reaction is strongly influenced by the electronic effects and number of the substituents on the phenyl ring. The resultant compound, bis(2,4-bis(benzyloxy)-5-methoxyphenyl)methane, was obtained in excellent yield (83-85%) and completely characterize with different spectroscopic techniques.
Atlanta Publishing House LLC
2014-09-30
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
text/plain
https://www.eurjchem.com/index.php/eurjchem/article/view/1086
10.5155/eurjchem.5.3.513-516.1086
European Journal of Chemistry; Vol. 5 No. 3 (2014): September 2014; 513-516
2153-2257
2153-2249
eng
https://www.eurjchem.com/index.php/eurjchem/article/view/1086/pdf_1086
https://www.eurjchem.com/index.php/eurjchem/article/view/1086/2564