2024-03-19T01:59:03Z
https://www.eurjchem.com/index.php/eurjchem/oai
oai:ojs.www.eurjchem.com:article/1172
2015-06-30T08:25:37Z
eurjchem:ART
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Synthesis, characterization, DNA-binding and biological activity of Zn(II) complexes of sulfadiazine with different amino acids
El-Henawy, Ahmed Abdlmonem
Hanafy, Ahmed Imam
Docking
Antifungal
Amino acid
Sulfadiazine
DNA-binding
Antibacterial activity
New Zn(II) complexes (ZnII-VS, ZnII-LS, ZnII-SS, ZnII-CS and ZnII-MS) of the sulfonamide antibiotic sulfadiazine with different amino acids were prepared and fully characterized by elemental analyses, thermal analysis and IR, UV/Vis and 1H NMR spectroscopy. The IR and 1H NMR spectral data show that the ligands behave in a dibasic bidentate fashion coordinating to zinc ion. Interactions of these complexes with DNA were investigated by spectrophotometric method. Moreover, the antibacterial and antifungal activities were evaluated for five ligands and their complexes. The computational study for prediction of absorption, distribution, metabolism, elimination and toxic factors (ADMET) properties were performed for the prepared ligands.
Atlanta Publishing House LLC
2015-06-30
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://www.eurjchem.com/index.php/eurjchem/article/view/1172
10.5155/eurjchem.6.2.117-126.1172
European Journal of Chemistry; Vol. 6 No. 2 (2015): June 2015; 117-126
2153-2257
2153-2249
eng
https://www.eurjchem.com/index.php/eurjchem/article/view/1172/pdf_1172