2024-03-19T04:56:58Z
https://www.eurjchem.com/index.php/eurjchem/oai
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2015-09-30T05:16:04Z
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Synthesis of some novel benzimidazole derivatives and their biological evaluation
Gund, Dnyandev Radhu
Rao, Balivada Venkata Satyasai Varaprasad
Mandhare, Pandurang Narayanrao
Vaidya, Sanjay Dashrath
Alkylation
Benzimidazole
Suzuki coupling
Antifungal activity
Phenyl boronic acid
Antibacterial activity
A series of novel benzimidazole derivatives have been synthesized by the condensation of o-phenylenediamine with 4-bromophenoxy acetic acid and product obtained was alkylated at the benzimidazole -NH with different electrophilic reagents. Subsequent reactions of the products by the Suzuki Coupling between benzimidazole derivatives and phenylboronic acid derivatives were accomplished. All these compounds were characterized by FT-IR, 1H NMR, MS and elemental analysis. These compounds were screened for their potential antibacterial and antifungal activities. This exhibited some promising results towards testing organism in-vitro.
Atlanta Publishing House LLC
2015-09-30
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://www.eurjchem.com/index.php/eurjchem/article/view/1242
10.5155/eurjchem.6.3.270-274.1242
European Journal of Chemistry; Vol. 6 No. 3 (2015): September 2015; 270-274
2153-2257
2153-2249
eng
https://www.eurjchem.com/index.php/eurjchem/article/view/1242/pdf_1242