2024-03-28T17:03:43Z
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2017-03-31T07:00:46Z
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Synthesis, antibacterial activities and phospholipid membrane interactions of novel dialkyl 2,2’-disulfanediyldibenzoates
Laulloo, Sabina Jhaumeer
Bhowon, Minu Gupta
Akerman, Matthew
Joondan, Nausheen
Momus, Marie Jessika
Lipophilicity
Dithiosalicylic acid
Dithio-bis-benzoates
Antibacterial activity
Phospholipid binding
X-ray crystallography
A series of dialkyl 2,2’-disulfanediyldibenzoates with alkyl chain length C8 to C12 were synthesized and characterized by spectral studies. The structure of compound 3 was also confirmed by X-ray crystallography. The compounds were found to possess good antibacterial activity, especially with respect to Gram positive bacteria, and the activity was found to increase with concomitant increase in chain length. Binding studies of compound 3 with the synthetic phospholipid 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) showed that the compound interacts with biological membrane mainly via hydrophobic interactions.
Atlanta Publishing House LLC
2017-03-31
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
text/plain
https://www.eurjchem.com/index.php/eurjchem/article/view/1540
10.5155/eurjchem.8.1.60-65.1540
European Journal of Chemistry; Vol. 8 No. 1 (2017): March 2017; 60-65
2153-2257
2153-2249
eng
https://www.eurjchem.com/index.php/eurjchem/article/view/1540/pdf_1540
https://www.eurjchem.com/index.php/eurjchem/article/view/1540/2590