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Synthesis and antimicrobial evaluation of substituted fluoroquinolones under conventional and microwave irradiation conditions
Prasad, Mutyala Veera Venkata Vara
Veranna, Vadde
Rao, Radha Hunasenahalli Raghavendra
Darsi, Sai Subramanyam Praveen Kumar
Morpholine
Thiomorpholine
Antimicrobial activity
Microwave irradiation
Substituted fluoroquinolones
2
3-Dichlorophenylpiperizine hydrochloride
A series of new fluoroquinolones analogs (3a-i) were prepared under conventional and microwave irradiation technique. Ethyl 1-cyclopropyl-6,7-difluoro-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylate (1) on reaction with boric acid and acetic anhydride in the presence of catalytic amount of zinc chloride under reflux, resulted in an unstable borate complex. Which was instantaneously treated with morpholine, piperidine, thiomorpholine, 2,6-dimethylmorpholine, 4,5,6,7-tetrahydrothieno[3,2-c]pyridine hydrochloride, 5,6,7,7a-tetrahydrothieno[3,2-c]pyridin-2(4H)-one hydrochloride, 2,3-dichlorophenylpiperazine hydrochloride, 3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride and 5,6,7,8-tetrahydro-[1,2,4] triazolo[4,3-a]pyrazine, in the presence of triethylamine to yield compounds 3a-i. The same compounds on the other hand synthesized using a microwave irradiation technique in the presence of triethylamine and adsorbed neutral alumina. The structures of the synthesized compounds were established on the basis of spectral and analytical data. The antimicrobial activity of newly synthesized compounds were evaluated against different microorganisms and found the compounds exhibited significant activity.
Atlanta Publishing House LLC
2017-06-30
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://www.eurjchem.com/index.php/eurjchem/article/view/1551
10.5155/eurjchem.8.2.144-148.1551
European Journal of Chemistry; Vol. 8 No. 2 (2017): June 2017; 144-148
2153-2257
2153-2249
eng
https://www.eurjchem.com/index.php/eurjchem/article/view/1551/pdf_1551