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oai:ojs.www.eurjchem.com:article/1586 2017-09-30T11:59:49Z eurjchem:SC driver

Synthesis of quinazolinones derivatives an antiproliferative agent against human lung carcinoma cells Deshmukh, Satish Uttamrao Kharat, Kiran Ramesh Kadam, Gajanan Gulabrao Pawar, Rajendra Pundlikrao Ionic liquid Green chemistry 2-Aminobenzamide Antiproliferative activity Lung carcinoma A549 cells 2 3‐Dihydroquinazolin‐4(1H)‐one 2,3‐Dihydroquinazolin‐4(1H)‐one derivatives (3a-p) were synthesized in excellent yields. These compounds were screened for antiproliferative activity against A549 cells and were found as potent cytotoxicity. Compounds A4, A8, A10 found to be more promising antiproliferative against the lung carcinoma A549 cells. IC50 values for compounds A4, A8 and A10 were found to be 8.6, 8.9 and 8.1 μg/L against A549 cells, respectively. Atlanta Publishing House LLC 2017-09-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/1586 10.5155/eurjchem.8.3.317-320.1586 European Journal of Chemistry; Vol. 8 No. 3 (2017): September 2017; 317-320 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/1586/pdf_1586