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oai:ojs.www.eurjchem.com:article/1783 2018-12-31T07:23:25Z eurjchem:ART driver

A novel and expeditious synthesis of oxazolidinone drugs linezolid and eperezolid Siddaraj, Ranjith Govindaiah, Shivaraja Ningegowda, Raghu Shivananju, Nanjunda Swamy Priya, Babu Shubha Linezolid Eperezolid Acetamide Sodium iodide Cesium carbonate (R)-2-(Bromomethyl)oxirane A concise and efficient synthesis of linezolid and eperezolid were accomplished through a convergent scheme utilizing diverse reaction conditions. The synthesis demonstrates utility of a new approach to facilitate the expeditious construction of 3-aryl-5-(substituted methyl)-2-oxazolidinones and easier insertion of N-acetyl group. This new approach offers the possibility of accessing related 2-oxazolidinone members easily as well as making additional analogues of Linezolid. The adopted method afforded high purity and excellent yield compared to other existing synthetic methods. The compounds were successfully characterized by known spectroscopic techniques. Atlanta Publishing House LLC 2018-12-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/1783 10.5155/eurjchem.9.4.353-359.1783 European Journal of Chemistry; Vol. 9 No. 4 (2018): December 2018; 353-359 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/1783/pdf_1783 Copyright (c) 2018 Authors