2024-03-29T06:30:00Z
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2020-06-30T03:45:36Z
eurjchem:ART
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Spectrum subtraction method for simultaneous determination of acetaminophen and caffeine in panadol extra dosage forms
Sebaiy, Mahmoud Mohammed
Mattar, Amr Abd El-Hakeem
Caffeine
ICH guidelines
Acetaminophen
Spectrophotometric
Spectrum subtraction
Statistical comparison
A simple, specific, accurate and precise spectrophotometric method was established for simultaneous determination of acetaminophen and caffeine in pure form and in their pharmaceutical formulation commercially known as Panadol Extra®. Spectrum subtraction has been used in simultaneous determination of both drugs without prior separation. Spectrum subtraction method parameters were validated according to ICH guidelines in which accuracy, precision, repeatability and robustness were found in accepted limits (98-102%). The linearity range was 7.5-45 µg/mL for caffeine and 4-22 µg/mL for acetaminophen with correlation coefficients ≥0.9990 for both drugs. Advantages and disadvantages of spectrum subtraction were discussed and statistical comparison between the proposed method and the reference one was performed.
Atlanta Publishing House LLC
2020-03-31
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://www.eurjchem.com/index.php/eurjchem/article/view/1956
10.5155/eurjchem.11.1.80-83.1956
European Journal of Chemistry; Vol. 11 No. 1 (2020): March 2020; 80-83
2153-2257
2153-2249
eng
https://www.eurjchem.com/index.php/eurjchem/article/view/1956/pdf_1956
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