2024-03-29T12:18:59Z
https://www.eurjchem.com/index.php/eurjchem/oai
oai:ojs.www.eurjchem.com:article/206
2011-06-30T10:44:15Z
eurjchem:ART
driver
Synthesis and anti-tubercular activity of novel pyrazol-5(H)-one derivatives
Raval, Jignesh Priyakant
Shah, Arpita Bharatbhai
Patel, Nilesh Hasmukhbhai
Patel, Hemul Venubhai
Patel, Pradip Shantilal
Bhatt, Kashyap Kanaiyalal
Desai, Kishor Ratilal
Isonicotinohydrazide
Pyrazol-5(H)-ones
Anti-tubercular activity
Anti-mycobacterial activity
Mycobacterium tuberculosis
M. tuberculosis H37Rv
In the present investigation, a series of 1-isonicotinoyl-3-methyl-4-(2-(substituted-phenyl)hydrazono)-1H-pyrazol-5(H)-ones were synthesized by the reaction between isonicotinohydrazide with substituted ethylacetoacetate derivatives using acetic acid as solvent which yielded substituted pyrazol-5(H)-one derivatives. Newly synthesized compounds were tested for their in vitro anti-tubercular activity against Mycobacterium tuberculosis H37Rv using the BACTEC 460 radiometric system. Among the synthesized compounds, 4-(2-(2,6-dichlorophenyl)hydrazono)-1-isonicotinoyl-3-methyl-1H-pyrazol-5(4H)-one and 4-(2-(1-isonicotinoyl-3-methyl-5-oxo-1H-pyrazol-4(5H)-ylidene)hydrazinyl) benzene-sulfonamide were found to be more active agent against M. tuberculosis H37Rv with minimum inhibitory concentration of 0.0034, 0.0032 µM at actual MIC 1.66 and 1.64 µg/mL, respectively.
Atlanta Publishing House LLC
2011-06-30
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://www.eurjchem.com/index.php/eurjchem/article/view/206
10.5155/eurjchem.2.2.238-242.206
European Journal of Chemistry; Vol. 2 No. 2 (2011): June 2011; 238-242
2153-2257
2153-2249
eng
https://www.eurjchem.com/index.php/eurjchem/article/view/206/PDF