2024-03-29T15:49:10Z
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oai:ojs.www.eurjchem.com:article/208
2011-04-06T06:03:47Z
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Synthesis and antimicrobial activities of some novel bis-pyrazole derivatives containing a hydrophosphoryl unit
Abdel-Aziz, Salah Abdel-Ghaffar
Ali, Tarik El-Sayed
El-Mahdy, Kamilia Mohamed
Abdel-Karim, Somaia Mohamed
Phosphonicdihydrazones
Hydro-phosphoryl
Vilsmeier-Haack reaction
Bis-pyrazoles
Sulfur-phosphorus heterocycles
Antimicrobial activity
Vilsmeier-Haack reaction conditions were applied on some methyl ketone aryl phosphonicdihydrazones to yield some interesting bis-pyrazole derivatives containing a hydro-phosphoryl unit. Bis-{4-formyl-3-aryl-1H-pyrazol-1-yl}phosphine oxides (4a,b) were condensed with some nucleophiles such as aniline, phenacyltriphenylphosphonium bromide and 4-phenylthiosemicarbazide followed by treatment with thioglycolic acid, diethyl phosphite and/or acetic anhydride to yield a novel class of bis-pyrazoles containing sulfur and phosphorus derivatives. Most of the newly synthesized compounds were evaluated for their in vitro antimicrobial activities.
Atlanta Publishing House LLC
2011-03-28
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://www.eurjchem.com/index.php/eurjchem/article/view/208
10.5155/eurjchem.2.1.25-35.208
European Journal of Chemistry; Vol. 2 No. 1 (2011): March 2011; 25-35
2153-2257
2153-2249
eng
https://www.eurjchem.com/index.php/eurjchem/article/view/208/PDF