2024-03-29T15:25:50Z
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2022-04-02T04:44:19Z
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Crystallographic structure, activity prediction, and hydrogen bonding analysis of some CSD-based 3,3'-bis-indole derivatives: A review
Sharma, Varun
Brahmachari, Goutam
Gupta, Vivek Kumar
Bis-indole
X-ray diffraction
Biological activity
Hydrogen bonding
Geometrical parameters
Bifurcated hydrogen bonds
Herein we report crystallographic comparison of some geometrical and structural features for a series of biologically relevant bis-indole derivatives. Selected bond distances and bond angles of interest in a series of bis-indole derivatives have been discussed in detail. The biological activity of the substances has been correlated with based the structure-activity relationships (SAR) base which provides the different possibility of activity (Pa) and possibility of inactivity (Pi). For a better understanding of the packing interactions existing among these derivatives, an overview of crystal structure analysis with emphasis on the intramolecular hydrogen bonding in some bis-indole derivatives is presented. The role of hydrogen bonding in the crystal structure assembly of bis-indole derivatives has been found to be predominant and this observation reveals significant impact of hydrogen bonding in high value of drug-likeness of these bio-molecules.
Atlanta Publishing House LLC
2021-12-31
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://www.eurjchem.com/index.php/eurjchem/article/view/2145
10.5155/eurjchem.12.4.493-501.2145
European Journal of Chemistry; Vol. 12 No. 4 (2021): December 2021; 493-501
2153-2257
2153-2249
eng
https://www.eurjchem.com/index.php/eurjchem/article/view/2145/pdf_2145
Copyright (c) 2021 Authors