2026-05-13T06:22:23Z https://www.eurjchem.com/index.php/eurjchem/oai

oai:ojs.www.eurjchem.com:article/2739 2026-03-31T05:13:14Z eurjchem:ART driver

Efficient synthesis of azoxystrobin and its key intermediate using a newer DABCO-based catalyst Dhande, Nilesh Dattatraya Pansare, Tushar Tulsidas Baviskar, Uday Vasudev Narkhede, Hemant Prabhakar Fungicide Azoxystrobin Organocatalysis Yield improvement DABCO-based catalyst Synthetic methodology A simple, convenient, and commercially feasible synthesis method has been developed for the synthesis of azoxystrobin and its intermediate using a DABCO-based catalyst. The methodology, which starts with coumaranone, uses a single catalyst for the two-step process, demonstrating high potential for industrial application. The catalyst synthesis and optimal catalyst concentration have been optimized to achieve maximum yield in the synthesis of the intermediate as well as technical azoxystrobin. The intermediate and final products, as well as the catalyst, were characterized by melting point, 1H NMR, 13C NMR, and high-resolution mass spectrometry. The HRMS analysis data supported the molecular formulae of the synthesized catalyst and product, showing the fragments m/z 143.1188 (M+H), C7H14N2O and 404.1262 (M+H), C22H17N3O5. The newer catalyst has the merits of being inexpensive, highly reactive, and environmentally friendly. The yield reached a high level, and this method can be considered a promising catalyst for the industrial-scale production of azoxystrobin and its key intermediate. Atlanta Publishing House LLC 2026-03-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/2739 10.5155/eurjchem.17.1.19-25.2739 European Journal of Chemistry; Vol. 17 No. 1 (2026): March 2026; 19-25 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/2739/2992 Copyright (c) 2026 Nilesh Dattatraya Dhande, Tushar Tulsidas Pansare, Uday Vasudev Baviskar, Hemant Prabhakar Narkhede https://creativecommons.org/licenses/by-nc/4.0