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oai:ojs.www.eurjchem.com:article/400 2011-12-31T08:09:40Z eurjchem:ART driver

Preparation and evaluation of a set of bis(methoxycarbonylmethylthio) heteroquinones as CDC25B phosphatase inhibitors Besset, Tatiana Braud, Emmanuelle Jarray, Rafika Garbay, Christiane Kolb, Stephanie Leo, Pierre-Marc Morin, Christophe Heterocyclic quinones CDC25B inhibitors Enzymatic activity Phosphatase Cancer Cell cycle A set of new heteroquinone derivatives bearing two methoxycarbonylmethylthio groups on the benzoquinone ring were synthesized and evaluated for CDC25B phosphatase inhibitory activity. All compounds inhibited the enzyme with IC50 values in the micromolar range regardless of the size and heteroatoms constituting the heterocycle fused to the quinone ring. Moreover, these quinonoid-based compounds showed moderate antiproliferative activity toward two cancer cell lines (HeLa and MiaPaca-2). These results provide additional data for CDC25 inhibition by quinone-type derivatives and highlight the importance of substituents on the quinonic moiety. Atlanta Publishing House LLC 2011-12-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/400 10.5155/eurjchem.2.4.433-440.400 European Journal of Chemistry; Vol. 2 No. 4 (2011): December 2011; 433-440 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/400/PDF