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oai:ojs.www.eurjchem.com:article/439
2011-09-30T03:44:50Z
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Facile synthesis of 3-(1-(4'-(3-chloro-2-(substituted phenyl)-4-oxoazetidin-1-yl)biphenyl-4-yl)-5-oxo-2-phenyl-1H-imidazol-4(5H)-ylidene)indolin-2-ones: β-Lactam derivatives as antimicrobes
Bishnoi, Abha
Srivastava, Krishna
Singh, Suruchi
Tripathi, Chandrakant Mani
Imidazole
Azetidinones
β-lactam ring
Bacillus subtilis
Candida albicans
Antimicrobial activity
A facile synthesis of b-lactam derivatives; 3-(1-(4'-(3-chloro-2-(substituted phenyl)-4-oxoazetidin-1-yl)biphenyl-4-yl)-5-oxo-2-phenyl-1H-imidazol-4(5H)-ylidene)indolin-2-ones (6a-e) and 3-(1-(3-chloro-2-(substituted phenyl)-4-oxoazetidin-1-yl)-5-oxo-2-phenyl-1H-imidazol-4(5H)-ylidene)indolin-2-ones (7a-e) is described herein. The title compounds 6a-e and 7a-e were evaluated for their in vitro antimicrobial activity against Candida albicans and Bacillus subtilis respectively using a two fold serial dilution technique. Investigation revealed that 2-hydroxy phenyl function at b-lactam ring in compounds 6d and 7d is a key factor for both antifungal and antibacterial activity, as newly designed compounds 6d and 7d exhibited good biological activity with minimum inhibitory concentration (MIC)12.5 mg/mL against Candida albicans and Bacillus subtilis respectively.
Atlanta Publishing House LLC
2011-09-30
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://www.eurjchem.com/index.php/eurjchem/article/view/439
10.5155/eurjchem.2.3.359-364.439
European Journal of Chemistry; Vol. 2 No. 3 (2011): September 2011; 359-364
2153-2257
2153-2249
eng
https://www.eurjchem.com/index.php/eurjchem/article/view/439/PDF