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2012-03-31T06:42:45Z
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Synthesis, spectral characterization and biological evaluation of 4H-1,4-benzothiazines, their sulfones and ribofuranosides
Gautam, Naveen
Ajmera, Neha
Gupta, Shikha
Gautam, Dinesh Chand
Sulfones
Heterocycles
Ribofuranosides
Antioxidant activity
Antimicrobial activity
4H-1
4-benzothiazines
Synthesis of heterocyclic compounds like benzothiazines has attracted attention in recent years due to their biological and industrial value. This article reflects up-to-date and comprehensive coverage of biochemical aspects of benzothiazines, their sulfones and ribofuranosides. The nitrogen and sulfur containing heterocycles were prepared by condensation followed by oxidative cyclization of 2-aminobenzenethiol with β-diketones/β-ketoesters in dimethylsulfoxide. These compounds were then used as base to prepare ribofuranosides by treating them with sugar (β-D-ribofuranose-1-acetate-2,3,5-tribenzoate). On refluxing with hydrogen peroxide in glacial acetic acid, these substituted dimethyl 4H-1,4-benzothiazines yielded 4H-1,4-benzothiazine-1,1-dioxides. Antioxidant and antimicrobial activity of these compounds were carried out and structure evaluation was done by spectral and elemental analysis.
Atlanta Publishing House LLC
2012-03-31
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://www.eurjchem.com/index.php/eurjchem/article/view/489
10.5155/eurjchem.3.1.106-111.489
European Journal of Chemistry; Vol. 3 No. 1 (2012): March 2012; 106-111
2153-2257
2153-2249
eng
https://www.eurjchem.com/index.php/eurjchem/article/view/489/PDF