2024-03-28T11:12:49Z
https://www.eurjchem.com/index.php/eurjchem/oai
oai:ojs.www.eurjchem.com:article/551
2012-08-06T14:50:19Z
eurjchem:ART
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Microwave-assisted solvent free efficient synthesis of 1,3,4-oxadiazole-2(3H)-thiones and their potent in vitro urease inhibition activity
Shahzad, Sohail Anjum
Yar, Muhammad
Khan, Zulfiqar Ali
Khan, Islam Ullah
Naqvi, Syed Ali Raza
Mahmood, Nasir
Khan, Khalid Mohammed
High yield
Hydrazides
Solvent free
Urease inhibition
Microwave-irradiation
Substituted-1
3
4-oxadiazole
An efficient solvent free microwave assisted synthesis of 5-substituted-1,3,4-oxadiazole-2(3H)-thiones (2a-2r) from hydrazides and carbon disulfide has been accomplished in good to excellent yield. The urease inhibition activity of the resulting compounds was investigated. Preliminary bioassay indicated that the compound 2j bearing 2-bromo substituent is the most active inhibitor exhibiting IC50 12.60 ± 0.92 μM.
Atlanta Publishing House LLC
2012-06-30
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://www.eurjchem.com/index.php/eurjchem/article/view/551
10.5155/eurjchem.3.2.143-146.551
European Journal of Chemistry; Vol. 3 No. 2 (2012): June 2012; 143-146
2153-2257
2153-2249
eng
https://www.eurjchem.com/index.php/eurjchem/article/view/551/PDF