2024-03-28T15:38:25Z
https://www.eurjchem.com/index.php/eurjchem/oai
oai:ojs.www.eurjchem.com:article/596
2012-08-06T14:50:19Z
eurjchem:ART
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In-vitro cytotoxic and radiosensitizing evaluation of novel 2-pyridone, isoquinoline, chromene and chromenopyridone derivatives
Al-Said, Mansour Sulaiman
El-Gazzar, Marwa Galal
Ghorab, Mostafa Mohammed
Cytotoxic
Chromene
2-Pyridone
Isoquinoline
Radiosensitizing
Chromenopyridone
On the account of the reported anticancer activity of 2-pyridone, a new series of ethyl-1,6-dihydropyridine-3-carboxylate (4a-j), 1-oxo-1,2-dihydroisoquinoline-7-carbonitrile (6a-h), 2H-chromene (7,8) and 3H-chromeno[3,4-c]pyridone derivatives (9,10) were synthesized and tested for in-vitro anticancer activity against Ehrlich Ascites Carcinoma (EAC) cell line and human liver cell line (HEPG2). The structures of the synthesized compounds were confirmed by analytical and spectral data. Furthermore, radiosensitization study was performed for the most potent compounds (4a, 4d, 6a, 6c, 6e and 10).
Atlanta Publishing House LLC
2012-06-30
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://www.eurjchem.com/index.php/eurjchem/article/view/596
10.5155/eurjchem.3.2.228-234.596
European Journal of Chemistry; Vol. 3 No. 2 (2012): June 2012; 228-234
2153-2257
2153-2249
eng
https://www.eurjchem.com/index.php/eurjchem/article/view/596/PDF