2024-03-29T07:46:38Z
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2013-06-30T03:41:05Z
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Synthesis, characterization and comparative study the antibacterial activities of some imine-amoxicillin derivatives
Tomi, Ivan Hameed Rouil
Abdullah, Amer Hasan
Al-Daraji, Ali Hussein Raheemah
Abbass, Selma Abdul Rudha
Schiff base
Amoxicillin
Penicillin A
Azomethine
Imine derivatives
Antibacterial activity
In this study, we report the synthesis of some new Schiff base compounds (1-5) from the reaction of amoxicillin with some aromatic aldehydes in classical Schiff base method. These derivatives were characterized by melting point, elemental analysis, FT-IR and 1H NMR data. All the synthesized compounds were evaluated in vitro for their antibacterial activities against two Gram positive (Staphylococcus aureus, Streptococcus faecalis) and two Gram negative (Escherichia coli, Pseudomonas aeruginosa) microorganisms in different concentrations (10-1, 10-3, 10-5 and 10-7 M) by agar diffusion disk method. The results showed that some of these derivatives have good antibacterial activities compared to biological activity of parent drug.
Atlanta Publishing House LLC
2013-06-30
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://www.eurjchem.com/index.php/eurjchem/article/view/751
10.5155/eurjchem.4.2.153-156.751
European Journal of Chemistry; Vol. 4 No. 2 (2013): June 2013; 153-156
2153-2257
2153-2249
eng
https://www.eurjchem.com/index.php/eurjchem/article/view/751/PDF