2024-03-28T14:10:56Z
https://www.eurjchem.com/index.php/eurjchem/oai
oai:ojs.www.eurjchem.com:article/829
2013-12-31T06:16:57Z
eurjchem:ART
driver
Simultaneous determination of Simvastatin and Sitagliptin in tablets by new univariate spectrophotometric and multivariate factor based methods
Lotfy, Hayam Mahmoud
Hegazy, Maha Abdel Monem
Abdel-Gawad, Sherif Abdel Naby
Sitagliptin
Univariate
Simvastatin
Multivariate
Chemometrics
Spectrophotometry
Five simple, sensitive and precise spectrophotometric and chemometric methods were used for simultaneous determination of Simvastatin (SM) and Sitagliptin (SIT) in their pure powdered forms and in the tablets. The proposed methods are the extended ratio subtraction method (EXRSM), ratio difference method (RDSM), mean centering of ratio spectra method (MCR) and chemometric methods, namely principal component regression (PCR) and partial least squares (PLS). In EXRSM; SM was determined at 237.5 nm, while SIT was determined at 267 nm, in RDSM; the difference in amplitudes at 237.5 and 245.5 nm was used for SM and 263.5 and 248.0 nm for SIT, while in MCR; SM and SIT were determined at 239.0 and 273.0 nm, respectively. PCR and PLS are factor based multivariate methods which utilize the whole spectra of SM and SIT. The developed methods were successfully applied for the determination of the studied drugs in their bulk powder, laboratory prepared mixtures and in tablets. All validation parameters of the developed methods were determined. The obtained results were statistically compared with each other along with a reported method.
Atlanta Publishing House LLC
2013-12-31
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://www.eurjchem.com/index.php/eurjchem/article/view/829
10.5155/eurjchem.4.4.414-421.829
European Journal of Chemistry; Vol. 4 No. 4 (2013): December 2013; 414-421
2153-2257
2153-2249
eng
https://www.eurjchem.com/index.php/eurjchem/article/view/829/PDF