2024-03-28T23:12:25Z
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2014-03-31T01:48:51Z
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Synthesis, reactions, antioxidant and anticancer evaluation of some novel coumarin derivatives using ethyl 2-(2-oxo-4-phenyl-2H-chromen-7-yloxy) acetate as a starting material
Halawa, Ahmed Hamdy
Hassan, Ahmed Abd El-Hameed
El-Nassag, Mohamed Ahmed
Abd El-All, Mahmoud Mohamed
Abd El-Jaleel, GehadAbd El-Raheem
Eliwa, Essam Mohamed
Bedair, Ahmed Hammam
Triazole
Oxadiazole
Cytotoxicity
Benzoimidazole
Antioxidant activity
Coumarinacetohydrazide
We report on the synthesis of new coumarin derivatives coupled with heterocyclic and bifunctionalized moieties at position 7. The proposed structures were confirmed by correct elemental analysis and spectral data (IR, MS, 1H NMR and 13C NMR). Some selected derivatives were also screened for their antioxidant and anticancer activities. The results indicated that 7-{[6-(4-nitrophenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-3-yl]methoxy}-4-phenyl-H-chromen-2-one has the highest antioxidant and anticancer activity in tested compounds.
Atlanta Publishing House LLC
2014-03-31
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://www.eurjchem.com/index.php/eurjchem/article/view/860
10.5155/eurjchem.5.1.111-121.860
European Journal of Chemistry; Vol. 5 No. 1 (2014): March 2014; 111-121
2153-2257
2153-2249
eng
https://www.eurjchem.com/index.php/eurjchem/article/view/860/PDF_860