2024-03-28T23:50:00Z
https://www.eurjchem.com/index.php/eurjchem/oai
oai:ojs.www.eurjchem.com:article/865
2014-03-31T01:48:51Z
eurjchem:ART
driver
Spectrophotometric methods for the simultaneous determination of paracetamol and dantrolene sodium in pharmaceutical dosage form
El-Bagary, Ramzia Ismail
Elkady, Ehab Farouk
Hegazi, Marwa Ahmed
Amin, Nour Eldin
Dosage form
Paracetamol
Dantrolene sodium
First derivative ratio
Spectrophotometric method
Simultaneous determination
Accurate, precise and simple spectrophotometric methods have been developed and validated for the determination of paracetamol (PAR) and dantrolene sodium (DAS). Spectrophotometric methods including zero order, first derivative (1D) and derivative ratio methods (1DD) have been developed. The zero order spectrophotometric method was used for the determination of DAS in the range of 1-20 μg/mL by measuring the absorbance at 379 nm where PAR exhibits zero reading. 1D and 1DD methods were used for the determination of PAR in the range of 1.5-20.0 μg/mL by measuring the peaks amplitudes at 265.5 nm and 265.0 nm, respectively. The proposed methods were used to determine PAR in binary mixture with DAS in the laboratory prepared mixtures and in pharmaceutical dosage form. The results obtained were statistically evaluated and found to be accurate and precise and can be satisfactorily applied for the quality control analysis of the cited drugs.
Atlanta Publishing House LLC
2014-03-31
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://www.eurjchem.com/index.php/eurjchem/article/view/865
10.5155/eurjchem.5.1.96-100.865
European Journal of Chemistry; Vol. 5 No. 1 (2014): March 2014; 96-100
2153-2257
2153-2249
eng
https://www.eurjchem.com/index.php/eurjchem/article/view/865/PDF_865