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2014-03-31T01:48:51Z
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Photostability studies on gemifloxacin and lomefloxacin in bulk powder and dosage forms
Tammam, Marwa Hosny
HPLC
LC-MS/MS
Gemifloxacin
Lomefloxacin
Photostability
Fluoroquinolone drugs
The photostability of gemifloxacin mesylate (GFLX) and lomefloxacin hydrochloride (LFLX) antibacterial agents in dilute aqueous solutions (bulk powder and dosage form) was studied by applying the International Conference on Harmonization (ICH) recommended conditions. The photodegradation processes were monitored by UV-Vis spectrophotometry and quantified by HPLC. The structures of degradation products in the aqueous solution have been deduced from LC-MS/MS. The GFLX and LFLX photodegradation kinetic rates were also determined. The photodegradation process for GFLX and LFLX solutions can be described as first order kinetic with rate constants 0.105 and 0.119 1/h, respectively, under the applied experimental conditions. The photodegradation rates of GFLX (0.119 1/h) and LFLX (0.0.157 1/h) in aqueous solutions were higher in dosage forms than bulk powder. Titanium dioxide cannot be used as an opacifier with these fluoroquinolone drugs because the rates of photodegradation of GFLX (0.0.161 1/h) and LFLX (0.0.164 1/h) were significantly enhanced by the addition of TiO2. The obtained results showed that these fluoroquinolone drugs are photolabile, thus these two drugs should be strictly protected from light during storage, administration and drug analysis.
Atlanta Publishing House LLC
2014-03-31
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://www.eurjchem.com/index.php/eurjchem/article/view/884
10.5155/eurjchem.5.1.73-80.884
European Journal of Chemistry; Vol. 5 No. 1 (2014): March 2014; 73-80
2153-2257
2153-2249
eng
https://www.eurjchem.com/index.php/eurjchem/article/view/884/PDF_884