2024-03-28T14:15:53Z
https://www.eurjchem.com/index.php/eurjchem/oai
oai:ojs.www.eurjchem.com:article/925
2014-03-31T01:48:51Z
eurjchem:ART
driver
Synthesis, characterization and in vitro evaluation of some new 5-benzylidene-1,3-thiazolidine-2,4-dione analogs as new class of α-glucosidase inhibitors
Nori, Divakara Laxman Somayajulu
Satyanarayan, Kasapu Vishnu Veera Venkata
Avupati, Vasudeva Rao
Bugata, Bharat Kumar
Yenupuri, Subhash
α-Glucosidase
Structure activity relationship
Aromatic/heteroaromatic ketone
Thiazolidine-2
4-dione derivatives
Minimum inhibitory concentration
5-Benzylidene-1
3-thiazolidine-2
4-dione
A series of 5-benzylidene-1,3-thiazolidine-2,4-dione derivatives (5a-u) were synthesized and tested against α-glucosidase. Preparation of the titled compounds was achieved by reaction of (Z)-4-((2,4-dioxo-1,3-thiazolidin-5-ylidene)methyl)benzaldehyde (4) and aromatic/hetero aromatic ketone. Among the compounds tested, (5p) and (5o) were identified as the most active in vitro with minimum inhibitory concentration (MIC) of 6.56±0.81 and 8.92±0.21 µg/mL against α-glucosidase, respectively. Evaluation of the structure activity relationship of substituents within these series has followed the discovery of a variety of compounds.
Atlanta Publishing House LLC
2014-03-31
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://www.eurjchem.com/index.php/eurjchem/article/view/925
10.5155/eurjchem.5.1.144-149.925
European Journal of Chemistry; Vol. 5 No. 1 (2014): March 2014; 144-149
2153-2257
2153-2249
eng
https://www.eurjchem.com/index.php/eurjchem/article/view/925/PDF_925