2026-04-21T01:01:43Z https://www.eurjchem.com/index.php/eurjchem/oai

oai:ojs.www.eurjchem.com:article/996 2014-09-30T03:41:50Z eurjchem:ART driver

Anticancer 4: Anticancer and DNA cleavage studies of some new Schiff base titanium (IV) complexes El-Shekeil, Ali Gumaan Abubakr, Abeer Omer Al-Aghbari, Sama Abdalla Nassar, Mogahid Yahya Titanium DNA studies Sulfamethoxazole Anti-cancer activity Schiff base complexes 3 4-Dimethoxybenzaldehyde Two metal complexes of Ti(IV) were synthesized with newly prepared biologically active ligands. These ligands and their functional groups were carefully designed and selected from well known anticancer drugs. The ligands were prepared by the condensation of a mixture of sulfamethoxazole and the appropriate aldehyde namely, 3,4-dimethoxybenzaldehyde and 3,4,5-trimethoxybenzaldehyde. The structure of the ligands and their complexes were confirmed by spectroscopic data i.e. IR, 1H NMR,electronic and elemental analysis. All compounds were screened for their in vitro anticancer potential using HELA and PC3 cells. All compounds showed limited cytotoxicity and complete cleavage of calf thymus deoxyribonucleic acid (CT-DNA). Atlanta Publishing House LLC 2014-09-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/996 10.5155/eurjchem.5.3.410-414.996 European Journal of Chemistry; Vol. 5 No. 3 (2014): September 2014; 410-414 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/996/pdf_996