European Journal of Chemistry 2015, 6(1), 78-83 | doi: https://doi.org/10.5155/eurjchem.6.1.78-83.1148 | Get rights and content






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Synthesis and characterization of new 3,5-disubstituted-4,5-dihydro-1H-pyrazole and their carbothioamide derivatives


Mohammad Mahmoud Ibrahim (1,*)

(1) Department of Chemistry, Faculty of Sciences, University of Al Al-Bayt, Al-Mafraq, 25113, Jordan
(*) Corresponding Author

Received: 08 Sep 2014 | Revised: 07 Oct 2014 | Accepted: 07 Oct 2014 | Published: 31 Mar 2015 | Issue Date: March 2015

Abstract


A new series of substituted pyrazolines (6-10) were synthesized in moderate to excellent yield by treatment of chalcones (1-5) with hydrazine monohydrate. The carbothioamide compounds (11-14) were obtained in 65% to quantitative yield by treatment of chalcones (2, 4, and 5) either with thiosemicarbazide or with phenylisothiocyanate. All new compounds were characterized by various spectroscopic methods such as 1H NMR, 13C NMR, DEPT, COSY, HSQC spectroscopy, elemental analysis, and high resolution mass spectroscopy. The obtained compounds are currently under biological investigations, and the results will be reported elsewhere.


Keywords


Chalcones; Pyrazolines; Isothiocyanate; Carbothioamide; Claisen-Schmidt; Thiosemicarbazide

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DOI: 10.5155/eurjchem.6.1.78-83.1148

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Funding information


Al Al-Bayt University (Mafraq, Jordan) and the German Academic Exchange Service (DAAD, Germany)

Citations

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[3]. Mahmoud Al-Refai, Mohammad M. Ibrahim, Sohail Alsohaili, Armin Geyer
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How to cite


Ibrahim, M. Eur. J. Chem. 2015, 6(1), 78-83. doi:10.5155/eurjchem.6.1.78-83.1148
Ibrahim, M. Synthesis and characterization of new 3,5-disubstituted-4,5-dihydro-1H-pyrazole and their carbothioamide derivatives. Eur. J. Chem. 2015, 6(1), 78-83. doi:10.5155/eurjchem.6.1.78-83.1148
Ibrahim, M. (2015). Synthesis and characterization of new 3,5-disubstituted-4,5-dihydro-1H-pyrazole and their carbothioamide derivatives. European Journal of Chemistry, 6(1), 78-83. doi:10.5155/eurjchem.6.1.78-83.1148
Ibrahim, Mohammad. "Synthesis and characterization of new 3,5-disubstituted-4,5-dihydro-1H-pyrazole and their carbothioamide derivatives." European Journal of Chemistry [Online], 6.1 (2015): 78-83. Web. 28 Nov. 2020
Ibrahim, Mohammad. "Synthesis and characterization of new 3,5-disubstituted-4,5-dihydro-1H-pyrazole and their carbothioamide derivatives" European Journal of Chemistry [Online], Volume 6 Number 1 (31 March 2015)

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