European Journal of Chemistry

Synthesis, characterization and antimicrobial studies of imine derivatives of amoxicillin



Main Article Content

Muhammad Islam
Zahid Shafiq
Mazhar Hussain
Hafiz Badaruddin Ahmad
Muhammad Ajaz Hussain

Abstract

Some novel imine derivatives (1-14) of a broad spectrum antibiotic amoxicillin were prepared by condensation with different carbonyl compounds. The amoxicillin imine derivatives were characterized using elemental analysis and spectroscopic techniques such as FT-IR and 1H NMR. The prepared imine derivatives were evaluated for antimicrobial activities against some pathogens using disc diffusion method. The results of present studies demonstrate enhanced antimicrobial activity of the novel imine derivatives of amoxicillin as compared to the parent drug.


icon graph This Abstract was viewed 2105 times | icon graph Article PDF downloaded 860 times

How to Cite
(1)
Islam, M.; Shafiq, Z.; Hussain, M.; Ahmad, H. B.; Hussain, M. A. Synthesis, Characterization and Antimicrobial Studies of Imine Derivatives of Amoxicillin. Eur. J. Chem. 2015, 6, 417-421.

Article Details

Share
Crossref - Scopus - Google - European PMC
References

[1]. Hay, S. I.; Battle, K. E.; Pigott, D. M.; Smith, D. L.; Moyes, C. L.; Bhatt, S.; Brownstein, J. S.; Collier, N.; Myers, M. F.; George, D. B.; Gething, P. W. Trans. R. Soc. Lond. B: Biol. Sci. 2013, 368, 20120250, 1-11.

[2]. Aoki, H.; Okuhara, M. Annu. Rev. Microbiol. 1980, 34, 159-181.
http://dx.doi.org/10.1146/annurev.mi.34.100180.001111

[3]. Kemal, U.; Palabiyik, L.; Karacan, E.; Feyyaz, O. Turk J. Pharm. Sci. 2008, 5, 1-16.

[4]. Qin, W.; Panunzio, M.; Biondi, S. Antibiotics 2014, 3, 193-215.
http://dx.doi.org/10.3390/antibiotics3020193

[5]. Utsui, Y.; Inoue, M.; Mitsuhashi, S. Antimicrob. Agents Chemother. 1987, 31, 1085-1092.
http://dx.doi.org/10.1128/AAC.31.7.1085

[6]. Sanders, C. C.; Sanders, W. E. Clin. Infect. Dis. 1992, 15, 824-839.
http://dx.doi.org/10.1093/clind/15.5.824

[7]. Leemans, E.; Fisher, J.; Mobashery, S.; Marinelli, F.; Genilloud, O. Eds.; Springer Berlin Heidelberg, 2014; pp 59-84.

[8]. Acuna, C.; Rabasseda, X. Drugs Today 2001, 37, 193-210.
http://dx.doi.org/10.1358/dot.2001.37.3.614856

[9]. Kaur, S. P.; Rao, R.; Nanda, S. Int. J. Pharm. Pharm. Sci. 2011, 3, 30-37.

[10]. Nazir, F.; Bukhari, I. H.; Arif, M.; Riaz, M.; Naqvi, S. A. R.; Bokhari, T. H.; Jamal, M. A. Int. J. Curr. Pharm. Res. 2013, 5, 40-47.

[11]. Bijev, A. T.; Hung, V. Arzneimitt. Forsch. 2001, 51, 667-672.

[12]. Tomi, I. H. R.; Abdullah, A. H.; Al-Daraji, A. H. R.; Abbass, S. A. R. Eur. J. Chem. 2013, 4(2), 153-156.
http://dx.doi.org/10.5155/eurjchem.4.2.153-156.751

[13]. Joshi, S. Int. J. Pharm. Biol. Sci. 2011, 2, 240-250.

[14]. Joshi, S.; Pawar, V.; Uma, V. Res. J. Pharm. Biol. Chem. Sci. 2011, 2, 61-70.

[15]. Al-Noor, T. H.; Aziz, M. R.; AL-Jeboori, A. T. J. Chem. Pharm. Res. 2014, 6, 1225-1231.

[16]. Abdel-Rahman, A. A. H.; Abdel-Megied, A. E. -S.; Hawata, M. A. A.; Kasem, E. R.; Shabanm, M. T. Monatsh. Chem. 2007, 138, 889-897.
http://dx.doi.org/10.1007/s00706-007-0700-8

[17]. Azevedo, C. M. P. G., PhD Thesis, 2012, http://hdl. handle.net/10216 /73974

[18]. Hameed, A.; Shafiq, Z.; Yaqub, M.; Hussain, M.; Hussain, M. A.; Afzal, M.; Tahir, M. N.; Naseer, M. M. New J. Chem. 2015, DOI: 10.1039/C5NJ01879J.
http://dx.doi.org/10.1039/C5NJ01879J

[19]. Chohan, Z. H.; Arif, M.; Shafiq, Z.; Yaqub, M.; Supuran, C. T. J. Enzyme Inhib. Med. Chem. 2006, 21(1), 95-103.
http://dx.doi.org/10.1080/14756360500456806

[20]. Hussain A.; Shafiq, Z.; Tahir, M. N.; Yaqub, M. Acta Crytallog. E 2010, 66(8), o1888-o1888.

[21]. Hameed, A.; Khan, K. M.; Zehra, S. T.; Ahmed, R.; Shafiq, Z.; Bakht, S. M.; Yaqub, M.; Hussain, M.; de Leon, A. de la V.; Furtmann, N.; Bajorath, J.; Shad, H. A.; Tahir, M. N.; Iqbal, J. Bioorg. Chem. 2015, 61, 51-57.
http://dx.doi.org/10.1016/j.bioorg.2015.06.004

[22]. Jodeh, S.; Stati, H.; Haddad, M.; Renno, T.; Zaid, A.; Jaradat, N.; Kharoaf, M. Eur. J. Chem. 2012, 3(4), 480‐484.
http://dx.doi.org/10.5155/eurjchem.3.4.480-484.698

[23]. El‐Sawi, E. A.; Mostafa, T. B.; Radwan, H. A. Eur. J. Chem. 2011, 2(4), 539‐543.
http://dx.doi.org/10.5155/eurjchem.2.4.539-543.55

Most read articles by the same author(s)
TrendMD

Dimensions - Altmetric - scite_ - PlumX

Downloads and views

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...
License Terms

License Terms

by-nc

Copyright © 2024 by Authors. This work is published and licensed by Atlanta Publishing House LLC, Atlanta, GA, USA. The full terms of this license are available at https://www.eurjchem.com/index.php/eurjchem/terms and incorporate the Creative Commons Attribution-Non Commercial (CC BY NC) (International, v4.0) License (http://creativecommons.org/licenses/by-nc/4.0). By accessing the work, you hereby accept the Terms. This is an open access article distributed under the terms and conditions of the CC BY NC License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited without any further permission from Atlanta Publishing House LLC (European Journal of Chemistry). No use, distribution, or reproduction is permitted which does not comply with these terms. Permissions for commercial use of this work beyond the scope of the License (https://www.eurjchem.com/index.php/eurjchem/terms) are administered by Atlanta Publishing House LLC (European Journal of Chemistry).