European Journal of Chemistry 2016, 7(2), 206-212 | doi: https://doi.org/10.5155/eurjchem.7.2.206-212.1410 | Get rights and content






  OPEN ACCESS | PEER-REVIEWED | RESEARCH ARTICLE | DOWNLOAD PDF | VIEW FULL-TEXT PDF | TOTAL VIEWS

Synthesis, characterization, physical and biological properties of some cholesterol derivatives


Nabeel Abed Abdul‐Reda (1,*) , Ahmed Kadhim Abass (2) , Noor Ali Gebur (3)

(1) Department of Chemistry, College of Education, Al-Qadisiyah University, Diwaniya, 58002, Al-Qadisiyah, Iraq
(2) Department of Chemistry, College of Science, Al-Qadisiyah University, Diwaniya, 58002, Al-Qadisiyah, Iraq
(3) Department of Chemistry, College of Science, Al-Qadisiyah University, Diwaniya, 58002, Al-Qadisiyah, Iraq
(*) Corresponding Author

Received: 10 Feb 2016 | Accepted: 10 Apr 2016 | Published: 30 Jun 2016 | Issue Date: June 2016

Abstract


A series of new cholesterol derivatives have been prepared via Mitsunobu reaction. The reaction was monitored by thin-layer chromatography (TLC) technique. All new compounds were characterized by melting points, elemental analysis, FT-IR, 1H, 13C and 2D-NMR spectroscopy. The antibacterial and antifungal activity of these derivatives was also determined. The phase transitions of the prepared derivatives were measured with the aid of differential scanning calorimetry. The textures of the mesophases have been determined with a hot stage equipped polarizing microscope, also the electrical conductivity of the solutions of these liquid crystals measured by electrical conductivity meter. The analysis showed that these prepared derivatives were liquid crystals.


Keywords


Steriods; Cholesterol; Liquid crystal; Thermal analysis; Mitsunobu reaction; Antimicrobial activity

Full Text:

PDF /    /


DOI: 10.5155/eurjchem.7.2.206-212.1410

Links for Article


| | | | | | |

| | | | | | |

Related Articles




Article Metrics

This Abstract was viewed 769 times | PDF Article downloaded 299 times

Funding information


Al-Qadisiyah University, Diwaniya, 58002, Al-Qadisiyah, Iraq

References

[1]. Lutfun, N.; Satyajit, D. S. Chemistry and Applications in Drug Design and Delivery, 1st edition, John Wiley & Sons, New York, 2012.

[2]. March, J.; Smith, M. B. Advanced Organic Chemistry, 6th edition, John Wiley & Sons, New Jersey, 2007.

[3]. Simeone, L. G. Bioconjugate Chem. 2012, 23, 758-770.
http://dx.doi.org/10.1021/bc200565v

[4]. Davis, A. P. Chem. Soc. Rev. 1993, 22, 243-253.
http://dx.doi.org/10.1039/cs9932200243

[5]. Yang, D. K.; Tson, S. Fundamentals of Liquid Crystal Devices, 2nd edition, John Wiley & Sons, California, 2006.
http://dx.doi.org/10.1002/0470032030

[6]. Khoo, I. C. Liquid Crystals, 2nd edition, Wiley Interscience, Florida, 2007.
http://dx.doi.org/10.1002/0470084030

[7]. Sluckin, T. J.; Dunmur, D. A.; Stegemeyer, H. Liq. Cryst. 2004, 17, 1-5.

[8]. Yang, D. K.; Wu, S. T. Fundamentals of Liquid Crystal Devices, 3rd edition, John Wiley and Sons, England, 2006
http://dx.doi.org/10.1002/0470032030

[9]. Yager, K. G.; Barrett, J. J. Photochem. Photobiol. A 2006, 182, 250-261.
http://dx.doi.org/10.1016/j.jphotochem.2006.04.021

[10]. Broer, D. J.; Mol, G. N.; VanHaaren, J. A. Adv. Mater. 1999, 7, 1-11.

[11]. Feringa, B. L.; VanDelden, R. A.; Koumura, N.; Geertsema, E. M. Chem. Rev. 2000, 100, 178-181.
http://dx.doi.org/10.1021/cr9900228

[12]. Fergason, J. Appl. Opt. 1968, 9, 17-29.

[13]. Kim, S. H.; Chien, L. C. Opt. Express 2004, 12, 12-38.

[14]. Kim, S. H.; Komitov, L.; Chien, L. C. Appl. Phys. Lett. 2005, 86, 161-118.

[15]. Yang, D. K.; Chien, L. C.; Doane, J. W. Appl. Phys. Lett. 1992, 60, 312-320.

[16]. Zeng, G. J.; Yu, F. H. Appl. Opt. 2003, 42, 153-157.
http://dx.doi.org/10.1364/AO.42.004427

[17]. Abdulhalim, I.; Abdulhalim, R. Acta Phys. Pol., A 2007, 5, 1-8.

[18]. Xianyu, H.; Faris, S.; Crawford, G. Appl. Opt. 2004, 43, 50-56.
http://dx.doi.org/10.1364/AO.43.005006

[19]. Goodby, J. W.; Görtz, V.; Cowling, S. J.; Mackenzie, G.; Martin, P.; Plusquellec, D.; Benvegnu, T.; Boullanger, P.; Lafont, D.; Chambert, Y. S.; Fitremann, J. Chem. Soc. Rev. 2007, 36, 1971-2128.
http://dx.doi.org/10.1039/b708458g

[20]. Helfrich, W. Appl. Phys. Lett. 1970, 17, 531-540.
http://dx.doi.org/10.1063/1.1653297

[21]. Al-Masoudi N. A.; Ali, D. S. Arch. Pharm. 2014, 347, 896-907.
http://dx.doi.org/10.1002/ardp.201400255

[22]. Manna, F. J. Med. Chem. 1992, 27, 633-639.
http://dx.doi.org/10.1016/0223-5234(92)90142-N

[23]. Sackman, E. J. Am. Chem Soc. 1971, 93, 70-88.
http://dx.doi.org/10.1021/ja00754a068

[24]. Eui, D. D.; Kim, K. N.; Kwon, Y. W.; Jin, J. I. Liq. Cryst. 2006, 33, 511-520.
http://dx.doi.org/10.1080/02678290600617546

[25]. Sorrll, T. N. Organic Chemistry, 2th edition, The University of California, 2006.

[26]. Overman, L. E.; Paone, D. V. J. Am. Chem. Soc. 2001, 123, 946-956.
http://dx.doi.org/10.1021/ja0166141

[27]. Blinov, L. M. Structure and Properties of Liquid Crystals, 3th edition, Springer Sciences, 2011.
http://dx.doi.org/10.1007/978-90-481-8829-1

[28]. Pieraccini, S.; Masiero, S.; Spada, G. P.; Gottarelli, G. Chem. Commun. 2003, 8, 598-599.
http://dx.doi.org/10.1039/b211421f

[29]. Saupe, A. Mol. Cryst. Liq. Cryst. Sci. Technol., Sect. A 1969, 7, 59-64.

[30]. Kahn, F. Phys. Rev. Lett. 1970, 24, 5-10.
http://dx.doi.org/10.1103/PhysRevLett.24.209

[31]. Kreuzer, H. J.; Tamblyn, I. Thermodynamics, 3rd edition, World Scientific, Co. Pte. Ltd., 2010.

[32]. Rey, I.; Dynarowicz, P.; Minones, J.; Seoane, R. J. Colloid Interface Sci. 2001, 234, 351-355.
http://dx.doi.org/10.1006/jcis.2000.7310

How to cite


Abdul‐Reda, N.; Abass, A.; Gebur, N. Eur. J. Chem. 2016, 7(2), 206-212. doi:10.5155/eurjchem.7.2.206-212.1410
Abdul‐Reda, N.; Abass, A.; Gebur, N. Synthesis, characterization, physical and biological properties of some cholesterol derivatives. Eur. J. Chem. 2016, 7(2), 206-212. doi:10.5155/eurjchem.7.2.206-212.1410
Abdul‐Reda, N., Abass, A., & Gebur, N. (2016). Synthesis, characterization, physical and biological properties of some cholesterol derivatives. European Journal of Chemistry, 7(2), 206-212. doi:10.5155/eurjchem.7.2.206-212.1410
Abdul‐Reda, Nabeel, Ahmed Kadhim Abass, & Noor Ali Gebur. "Synthesis, characterization, physical and biological properties of some cholesterol derivatives." European Journal of Chemistry [Online], 7.2 (2016): 206-212. Web. 6 Aug. 2020
Abdul‐Reda, Nabeel, Abass, Ahmed, AND Gebur, Noor. "Synthesis, characterization, physical and biological properties of some cholesterol derivatives" European Journal of Chemistry [Online], Volume 7 Number 2 (30 June 2016)

The other citation formats (EndNote | Reference Manager | ProCite | BibTeX | RefWorks) for this article can be found online at: How to cite item


DOI Link: https://doi.org/10.5155/eurjchem.7.2.206-212.1410

| | | | | | |

| | | | | |

Save to Zotero Save to Mendeley



European Journal of Chemistry 2016, 7(2), 206-212 | doi: https://doi.org/10.5155/eurjchem.7.2.206-212.1410 | Get rights and content

Refbacks

  • There are currently no refbacks.




Copyright (c)




© Copyright 2010 - 2020  Atlanta Publishing House LLC All Right Reserved.

The opinions expressed in all articles published in European Journal of Chemistry are those of the specific author(s), and do not necessarily reflect the views of Atlanta Publishing House LLC, or European Journal of Chemistry, or any of its employees.

Copyright 2010-2020 Atlanta Publishing House LLC. All rights reserved. This site is owned and operated by Atlanta Publishing House LLC whose registered office is 2850 Smith Ridge Trce Peachtree Cor GA 30071-2636, USA. Registered in USA.

hatay escort hatay escort corlu escort corum escort burgaz escort giresun escort aydin escort ordu escort erzincan escort hatay escort sivas escort rize escort edirne escort aksaray escort kibris escort isparta escort erzurum escort tekirdag escort usak escort urfa escort kastamonu escort kibris escort manisa escort giresun escort urfa escort nevsehir escort sivas escort yalova escort ordu escort hatay escort yalova escort amasya escort kayseri escort ordu escort maras escort canakkale escort yalova escort balikesir escort manisa escort urfa escort mugla escort trabzon escort bolu escort corlu escort diyarbakir escort isparta escort kutahya escort elazig escort erzurum escort sakarya escort afyon escort kutahya escort konya escort agri escort cesme escort sinop escort sivas escort konya escort kibris escort adapazari escort luleburgaz escort adana escort kibris escort rize escort sakarya escort alanya escort isparta escort burdur escort konya escort bitlis escort canakkale escort sivas escort amasya escort mus escort aydin escort van escort yalova escort kastamonu escort mardin escort bolu escort afyon escort sakarya escort isparta escort tokat escort trakya escort bayburt escort urfa escort mardin escort