European Journal of Chemistry 2017, 8(4), 344-348. doi:10.5155/eurjchem.8.4.344-348.1630

Synthesis and antioxidant study of new hydrazones derived from bisdemethoxycurcumin pyrazole


Tahseen Abdul Qader Alsalim (1,*) , Hussain Ali Mzban (2) , Einas Nasir Abood (3)

(1) Chemistry Department, College of Education for Pure Sciences, University of Basrah, Basrah, 16001, Iraq
(2) Chemistry Department, College of Education for Pure Sciences, University of Basrah, Basrah, 16001, Iraq
(3) Center of Polymer Research, University of Basrah, Basrah, 16001, Iraq
(*) Corresponding Author

Received: 14 Jul 2017, Accepted: 10 Sep 2017, Published: 31 Dec 2017

Abstract


The antioxidant activity of new hydrazones derived from bisdemethoxycurcumin pyrazole was investigated. The study was divided into two main parts: The first one includes the synthesis and characterization of the target compounds from bisdemethoxycurcumin (BDMC), while the second step is devoted to the investigation of their antioxidant activities. In the first step of synthesis, the curcumin-pyrazole (2) was synthesized by the reaction of BDMC with hydrazine hydrate. Later, the obtained product treated with ethyl 2-chloroacetate to produce curcumine ester (3), then the product was converted to hydrazide (4) by the reaction of curcumin ester (3) with hydrazine hydrate. Finally, curcumine hydrazones (5a-f) were synthesized from the reaction of hydrazide (4) with substituted aromatic aldehydes. All compounds were characterized with the aid of suitable spectroscopic techniques. The antioxidant activity of the prepared compounds was studied against the stable radical α,α-diphenyl-β-picrylhydrazyl. The study showed that only the phenolic OH-containing compounds (2, 5b and 5f) have antioxidant activity.


Keywords


Pyrazole; Hydrazone; Curcuminoids; Antioxidant activity; Bisdemethoxycurcumin; α,α-Diphenyl-β-picrylhydrazyl

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DOI: 10.5155/eurjchem.8.4.344-348.1630

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How to cite


Alsalim, T.; Mzban, H.; Abood, E. Eur. J. Chem. 2017, 8(4), 344-348. doi:10.5155/eurjchem.8.4.344-348.1630
Alsalim, T.; Mzban, H.; Abood, E. Synthesis and antioxidant study of new hydrazones derived from bisdemethoxycurcumin pyrazole. Eur. J. Chem. 2017, 8(4), 344-348. doi:10.5155/eurjchem.8.4.344-348.1630
Alsalim, T., Mzban, H., & Abood, E. (2017). Synthesis and antioxidant study of new hydrazones derived from bisdemethoxycurcumin pyrazole. European Journal of Chemistry, 8(4), 344-348. doi:10.5155/eurjchem.8.4.344-348.1630
Alsalim, Tahseen, Hussain Ali Mzban, & Einas Nasir Abood. "Synthesis and antioxidant study of new hydrazones derived from bisdemethoxycurcumin pyrazole." European Journal of Chemistry [Online], 8.4 (2017): 344-348. Web. 22 May. 2019
Alsalim, Tahseen, Mzban, Hussain, AND Abood, Einas. "Synthesis and antioxidant study of new hydrazones derived from bisdemethoxycurcumin pyrazole" European Journal of Chemistry [Online], Volume 8 Number 4 (31 December 2017)

DOI Link: https://doi.org/10.5155/eurjchem.8.4.344-348.1630

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